Protein Alignment alka and GABRA4

DIOPT Version :10

• Sequence 1: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_000800.2
• Gene: GABRA4 / 2557
• HGNCID: 4078
• Length: 554
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 136/564 - (24%)
• Similarity: 228/564 - (40%)
• Gaps: 154/564 - (27%)

  Fly    11 ISFGLGFILM-------WLSEA-----------TEAHMNYTAKPRVV--LPPNYVKEIRPPSKKG 55
            :|.|:.|.|:       .|:|:           ||   |:|   |::  |...|...:||..  |
Human    12 LSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTE---NFT---RILDSLLDGYDNRLRPGF--G 68

  Fly    56 SPVI-VDFSIFVVDINSINVEDMDFRVDMFIHQRWLESRLEI--PDDIFEEGDDYVTLLPEVFEN 117
            .||. |...|:|.....::..:|::.:|:|..|.|::.||:.  |.:|....:..||       .
Human    69 GPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVT-------K 126

  Fly   118 FWQPDPYFLNSKIAEIATLTHKFTS----VTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQVCP 178
            .|.||.:|.|.|    .:::|..|:    ..:.:|.|:.|..|:.....|.|....:|||...||
Human   127 VWTPDTFFRNGK----KSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACP 187

  Fly   179 IYIESFSSNNQKVKLRWSDSGVTLNPE---------LKLLQYNL-GQPLELEESDGYMPEKVGNF 233
            :...|::....::...|     |..||         ..|:||:| ||.:..|.    :....|.:
Human   188 LKFGSYAYPKSEMIYTW-----TKGPEKSVEVPKESSSLVQYDLIGQTVSSET----IKSITGEY 243

  Fly   234 SRLTVYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTGA-- 296
            ..:||||...|::|:.:|||:.|..:.|:||..|||:..:::|.|....:|.:||:.|:...|
Human   244 IVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARH 308

  Fly   297 DIPPVAYVKALDLWMAGCMLSVFAALAEFVVVKVL-DVQYQ---YQVNRIPKVLPMRISNMEKGQ 357
            .:|.|:|..|:|.::|.|...||:||.||..|... ::|.:   .:.::.|:.:|......||..
Human   309 SLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQEVPAAPVQREKHP 373

  Fly   358 CATVASWEGGAVRSRKAT----QTPTTPGQTSLQGN--------------GGP-------PKPAR 397
            .|.:.:.... :..||.|    .:.:..|..:..||              |.|       |.|..
Human   374 EAPLQNTNAN-LNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQESSKGTPRSYLASSPNPFS 437

  Fly   398 R----------QSLLSVAWTDTDTG--------------------VEKIM--------------- 417
            |          ::|.|.:.|...||                    :::|.
Human   438 RANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFGSRLQRIKTTVNTIGATGKLSAT 502

  Fly   418 ------------WREIDKVSRAVFPILFFVFVLLYWPILLMKSS 449
                        ..:|||.:|.:||:.|..|.::||.:.|.|.:
Human   503 PPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDT 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alka	NP_610619.2	LIC	8..441	CDD:455710	132/554 (24%)
GABRA4	NP_000800.2	LIC	13..541	CDD:455710	134/556 (24%)
		LGIC_ECD_GABAAR_A4	57..255	CDD:349838	56/219 (26%)
		Cys-loop	172..186	CDD:349838	5/13 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..381		5/30 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..435		6/37 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..471		4/18 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	495..515		0/19 (0%)