DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12344 and GABRA3

DIOPT Version :9

Sequence 1:	NP_001286298.1	Gene:	CG12344 / 36145	FlyBaseID:	FBgn0033558	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_000799.1	Gene:	GABRA3 / 2556	HGNCID:	4077	Length:	492	Species:	Homo sapiens

Alignment Length:	464	Identity:	125/464 - (26%)
Similarity:	212/464 - (45%)	Gaps:	88/464 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 NYTAKPRVV--LPPNYVKEIRPPSKKGSPVI-VDFSIFVVDINSINVEDMDFRVDMFIHQRWLES 92
            |.|...|::  |...|...:||  ..|..|. |...|:|.....::..||::.:|:|..|.|.:.
Human    63 NITIFTRILDRLLDGYDNRLRP--GLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDE 125

  Fly    93 RLEIPDDIFEEGDDYVTLLP---EVFENFWQPDPYFLNSKIAEIATLTHKFTS----VTLYKNKT 150
            ||:.        |..:.:||   .:....|.||.:|.|.|    .::.|..|:    :.|..|.|
Human   126 RLKF--------DGPMKILPLNNLLASKIWTPDTFFHNGK----KSVAHNMTTPNKLLRLVDNGT 178

  Fly   151 VRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRWSDSGVTLNPEL-----KLLQ 210
            :.|..|:.....|.|..:.:|||:..||:...|::....:|...|: .|...:.|:     :|.|
Human   179 LLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWT-LGKNKSVEVAQDGSRLNQ 242

  Fly   211 YN-LGQPLELEESDGYMPEKVGNFSRLTVYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLGLDA 274
            |: ||..:..|    .:....|.:..:|.:|..:|:||:.:|||:.|..:.|:||..||||..::
Human   243 YDLLGHVVGTE----IIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRES 303

  Fly   275 IPGRVTLLVTCMLTLVTMFTGA--DIPPVAYVKALDLWMAGCMLSVFAALAEFVVVKVLDVQ-YQ 336
            :|.|....||.:||:.|:...|  .:|.|||..|:|.::|.|...||:||.||..|.....: :.
Human   304 VPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWA 368

  Fly   337 YQVNRIPKVLPMR-----------------------ISNMEKGQCATVASWEGGAVRSRKATQTP 378
            ::..::|:.|.|:                       |:..:..:.:|::.   ||..|  |:.||
Human   369 WEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISK---GAAPS--ASSTP 428

  Fly   379 T---TPGQTSLQGNGGPPKPARRQSLLSVAWTDTDTGVEKIMWREIDKVSRAVFPILFFVFVLLY 440
            |   :|..|.:|.:     |...::..||:              ::||:||.:||:||.:|.|:|
Human   429 TIIASPKATYVQDS-----PTETKTYNSVS--------------KVDKISRIIFPVLFAIFNLVY 474

  Fly   441 WPILLMKSS 449
            |...:.:.|
Human   475 WATYVNRES 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12344	NP_001286298.1	LIC	8..441	CDD:273305	122/454 (27%)
GABRA3	NP_000799.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..54
		LIC	69..478	CDD:273305	122/451 (27%)
		LGIC_ECD_GABAAR_A3	75..274	CDD:349837	53/217 (24%)
		Cys-loop	191..205	CDD:349837	5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820