DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12344 and GABRA2

DIOPT Version :9

Sequence 1:	NP_001286298.1	Gene:	CG12344 / 36145	FlyBaseID:	FBgn0033558	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_001317619.1	Gene:	GABRA2 / 2555	HGNCID:	4076	Length:	511	Species:	Homo sapiens

Alignment Length:	520	Identity:	133/520 - (25%)
Similarity:	218/520 - (41%)	Gaps:	108/520 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ISFGLGFILMW------LS--EATEAHMNYTAKPRVV--LPPNYVKEIRPPSKKGSPVIVDF-SI 64
            :.|.|...|:|      |:  :..||..|.|...|::  |...|...:||  ..|..:...| :|
Human    10 MQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRP--GLGDSITEVFTNI 72

  Fly    65 FVVDINSINVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSK 129
            :|.....::..||::.:|:|..|:|.:.||:     |:...:.:.|...:....|.||.:|.|.|
Human    73 YVTSFGPVSDTDMEYTIDVFFRQKWKDERLK-----FKGPMNILRLNNLMASKIWTPDTFFHNGK 132

  Fly   130 --IAEIATLTHKFTSVTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVK 192
              :|...|:.:|.  :.:..:.|:.|..|:.....|.|..:.:|||...||:...|::....:|.
Human   133 KSVAHNMTMPNKL--LRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVT 195

  Fly   193 LRW----SDSGVTLNPE-LKLLQYN-LGQPLELEESDGYMPEKVGNFSRLTVYFRFERQIGHHLI 251
            ..|    ||| |.:.|: .:|.||: |||.:..|.    :....|.::.:|.:|..:|:||:.:|
Human   196 YIWTYNASDS-VQVAPDGSRLNQYDLLGQSIGKET----IKSSTGEYTVMTAHFHLKRKIGYFVI 255

  Fly   252 QTFAPSSLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTGA--DIPPVAYVKALDLWMAGC 314
            ||:.|..:.|:||..||||..:::|.|....||.:||:.|:...|  .:|.|||..|:|.::|.|
Human   256 QTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVC 320

  Fly   315 MLSVFAALAEFVVV-----------------------KVLDVQYQYQVNRIPKVLP--------- 347
            ...||:||.||..|                       |...:...|  |.:..:|.
Human   321 YAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKSPSIKAEGITLTY--NSVKAILQGAKLIWSKY 383

  Fly   348 -----------------------MRISNMEKGQCATVASWEGGAVRSRKATQTPT---TPGQTSL 386
                                   :......|.:.|:|.. :..|.....|...|.   .|..:::
Human   384 IAFSWPSLFQEKTLEYLEKWMDCLTFKQSSKKEKASVMI-QNNAYAVAVANYAPNLSKDPVLSTI 447

  Fly   387 QGNGGPPKPARRQSLLSVAWTDTDTGVEKIMWREIDKVSRAVFPILFFVFVLLYW-------PIL 444
            ..:...|:|.::..........|...|.|     ||::||.|||:||..|.|:||       |:|
Human   448 SKSATTPEPNKKPENKPAEAKKTFNSVSK-----IDRMSRIVFPVLFGTFNLVYWATYLNREPVL 507

Fly 445 444
Human 508 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12344	NP_001286298.1	LIC	8..441	CDD:273305	129/508 (25%)
GABRA2	NP_001317619.1	LIC	25..500	CDD:273305	127/496 (26%)
GABRA2	NP_001317619.1	LGIC_ECD_GABAAR_A2	47..249	CDD:349836	55/215 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920