Protein Alignment CG12344 and GABRR3

DIOPT Version :9

• Sequence 1: NP_001286298.1
• Gene: CG12344 / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_001099050.1
• Gene: GABRR3 / 200959
• HGNCID: 17969
• Length: 467
• Species: Homo sapiens
• Alignment Length: 417
• Identity: 116/417 - (27%)
• Similarity: 196/417 - (47%)
• Gaps: 51/417 - (12%)

  Fly    51 PSKKGSPVIVDFSIFVVDINSINVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDYVTLLPEVF 115
            |...||||.|...:.|..|:||:..:|||.:..::...|.:.||..|    ...:..:|....:.
Human    76 PGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFP----STANKSMTFDHRLT 136

  Fly   116 ENFWQPDPYFLNSKIAEIATLTHKFTSVTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQVCPIY 180
            ...|.||.:|::||.:.|...|.:...:.::.:..|..:.|:.....|.|:|..:|:|.|.|.:.
Human   137 RKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPLDTQNCSLE 201

  Fly   181 IESFSSNNQKVKLRWSDSGVTLNPE--LKLLQYNLGQPLELEESDGY-MPEKVGNFSRLTVYFRF 242
            :||::.|...:.|.|.....:||.|  :.|.|:.:.   :...|.|. .....|.::||.:.|..
Human   202 LESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIE---DFSASSGLAFYSSTGWYNRLFINFVL 263

  Fly   243 ERQIGHHLIQTFAPSSLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFT--GADIPPVAYVK 305
            .|.:...::||:.|:.|:|||||.|||:...|:|.||:|.:|.:||:.|:.|  .|.:|.|:|:|
Human   264 RRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIITAVSASMPQVSYLK 328

  Fly   306 ALDLWMAGCMLSVFAALAEFVVVKVL-DVQYQYQVNRIPKVLPMRISNMEKGQC----------- 358
            |:|:::....|.||.::.|:..|..| .|:.:.|..:..|:  .|:.|::..|.
Human   329 AVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKTGKI--SRMYNIDAVQAMAFDGCYHDSE 391

  Fly   359 ----ATVASWEGGAVRSRKATQTPTTPGQTSLQGNGGPPKPARRQSLLSVAWTDTDTGVEKIMWR 419
                .|..|........||:..:|:|...          :..||:||        ...|.:|:..
Human   392 IDMDQTSLSLNSEDFMRRKSICSPSTDSS----------RIKRRKSL--------GGHVGRIILE 438

  Fly   420 E---IDKVSRAVFPILFFVFVLLYWPI 443
            .   ||..||.:|||::.:|.|.||.:
Human   439 NNHVIDTYSRILFPIVYILFNLFYWGV 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12344	NP_001286298.1	LIC	8..441	CDD:273305	114/413 (28%)
GABRR3	NP_001099050.1	LIC	55..466	CDD:273305	116/417 (28%)
		Neur_chan_LBD	59..267	CDD:280998	52/197 (26%)
		Neur_chan_memb	274..463	CDD:280999	61/208 (29%)
		Interaction with SQSTM1. /evidence=ECO:0000250	347..448		23/120 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810