Protein Alignment alka and lgc-56

DIOPT Version :10

• Sequence 1: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_494951.3
• Gene: lgc-56 / 191638
• WormBaseID: WBGene00001588
• Length: 445
• Species: Caenorhabditis elegans
• Alignment Length: 444
• Identity: 118/444 - (26%)
• Similarity: 197/444 - (44%)
• Gaps: 64/444 - (14%)

  Fly    28 AHMNYTAKPR----VVLPPNYVKEIRPPSKKGSPVIVDFSIFVVDINSINVEDMDFRVDMFIHQR 88
            ||..|.:..|    ..|..:|.|.:.|   ..:.|.|...:.|.||:||:.....|..|::..|.
 Worm    27 AHCEYNSNHRKSILTDLLQDYDKTMVP---SNNSVQVSVELTVQDISSISEISSSFIADVWFSQV 88

  Fly    89 WLESRLEIPDDIFEEG---DDYVTLLPEVFENFWQPDPYFLNSKIAEIATLTHKFTS----VTLY 146
            |.:.|||..:...:..   |.||:      |..|.|:..|:|||    :|..||..:    :.:|
 Worm    89 WYDPRLEYRNISCKTNLSLDSYVS------ERLWTPNVCFVNSK----STQVHKSPASNILLIIY 143

  Fly   147 KNKTVRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRWSD-SGVTLNP--ELKL 208
            .|.||....|:.....|..|...:|:|.|.|.:..||:|.|..:|:|.|.. :.||:.|  :.:|
 Worm   144 PNGTVWLNYRVQVSAPCSFELSRFPIDAQECHLVFESYSYNIAEVRLNWQQWAPVTMPPPEDFRL 208

  Fly   209 LQYNLGQPLELEESDGYMPEKVGNFSRLTVYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLGLD 273
            ..:........:.|:.|   ..|.:.:|.|.|||:|..|::::|.:.|:.|.|.:||.:||:...
 Worm   209 PDFQFYNVTWGKTSNEY---TAGMWDQLKVTFRFKRLYGYYVLQMYLPTYLSVFISWIAFWIDTR 270

  Fly   274 AIPGRVTLLVTCMLTLVTMFTG--ADIPPVAYVKALDLWMAGCMLSVFAALAEFVVVKVLD---- 332
            |:|.|:||.|:.::.|...|..  .::|.|::|||:|||...|:..:|.:|.|..||..:|
 Worm   271 ALPARITLGVSSLMALTFQFGNIVKNLPRVSFVKAIDLWFFVCVAFIFFSLVELAVVGFVDKITE 335

  Fly   333 -------VQYQYQV--NRIPKVLPMRISNMEKGQCATVASWEGGAVRSRKATQTPTTPGQTSLQG 388
                   :::|..:  ..|....|:   :..|..|.:..:.....:.:....:.....|:|:  |
 Worm   336 IKRRSRRIKFQRAIAGGTIKNDRPV---SFRKYSCTSKCNSVRYNINNNDDEELYNISGETN--G 395

  Fly   389 NGGPPKPARRQSLLSVAW-TDTDTGVEKIMWREIDKVSRAVFPILFFVFVLLYW 441
            ||             |:| .::.......|...:|..:...||.:|..|.:.||
 Worm   396 NG-------------VSWKNNSSREASADMGARVDSFAAKAFPAMFAAFNVFYW 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alka	NP_610619.2	LIC	8..441	CDD:455710	116/442 (26%)
lgc-56	NP_494951.3	LIC	39..439	CDD:455710	114/432 (26%)
		LGIC_ECD_GABAAR	58..241	CDD:349791	57/195 (29%)
		Cys-loop	160..174	CDD:349791	5/13 (38%)