Protein Alignment alka and lgc-44

DIOPT Version :10

• Sequence 1: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_505954.2
• Gene: lgc-44 / 179600
• WormBaseID: WBGene00009790
• Length: 618
• Species: Caenorhabditis elegans
• Alignment Length: 432
• Identity: 102/432 - (23%)
• Similarity: 177/432 - (40%)
• Gaps: 106/432 - (24%)

  Fly    30 MNYTAKPRVVLPPNYVKEIRPPS-KKGSPVIVDFSIFVVDINSINVEDMDFRVDMFIHQRWLESR 93
            |.|.|:             :||| .....|.|...|.|..:::..:..||:.:|.::...|::.|
 Worm   257 MEYDAR-------------QPPSLHVDDTVTVKVGIAVQSMSNFELSTMDYDLDAWVRMSWIDPR 308

  Fly    94 L--EIPDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSKIAEIATLTHK------------FTSVT 144
            |  ::...|..  :||..|     :..|:|||.|.|||.:....:|:.            |..:.
 Worm   309 LRHDLSRPILV--NDYTFL-----KMIWRPDPIFTNSKYSTFHKVTYLNFYLFIFPDGKIFMDMR 366

  Fly   145 LYKNKTVRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRW---SDSGVTLNPEL 206
            :|...|   ||:   |:.|:     ||.|.....:.|.|.......|||.|   ::..:.:...:
 Worm   367 VYLKPT---AAQ---IVLCK-----YPHDNPAVSLKISSMGFTQDVVKLEWFSDTNDAIWIEKNV 420

  Fly   207 KLLQYNLGQPLELEESDGYMPEKVGNFSRLTVYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLG 271
            |:.:.:: :.|..:..:|.  .|.|.:|.|...|...|::|:|:..|:.|:::.|:.||.|.||.
 Worm   421 KIPELSI-RHLHPDTCNGV--RKSGVYSCLEAKFYMHREVGYHIANTYIPTAICVVFSWISVWLP 482

  Fly   272 LDAIPGRVTLLVTCMLTLVTMFTGA--DIPPVAYVKALDLWMAGCMLSVFAALAEFVVVKVLDVQ 334
            .:.:.||:.:.:|..|||......|  ::|.|:||||:|:|        |...:.||.:.:|
 Worm   483 EEFVEGRIFVSLTVFLTLSAENNSAKEELPKVSYVKAIDIW--------FGFTSTFVFLTML--- 536

  Fly   335 YQYQVNRIPKVLPMRISNMEKGQCATVASWEGGAVRSRKATQTPTTPGQTSLQGN-GGPPKPARR 398
                                  |...|.|.|..:.|.|           ...:.| .|..|....
 Worm   537 ----------------------QALVVISLEHNSKRLR-----------LKFENNLDGYSKYQMT 568

  Fly   399 QSLLSVAWTDTDTGVEKIMWREIDKVSRAVFPILFFVFVLLY 440
            :|:|...:...       |.|:||...:.::|::|.:|::.|
 Worm   569 KSMLLSRYYHR-------MARQIDTFCKVMYPVIFLLFLMFY 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alka	NP_610619.2	LIC	8..441	CDD:455710	102/432 (24%)
lgc-44	NP_505954.2	LGIC_ECD_anion	273..456	CDD:349788	47/203 (23%)
		Cys-loop	374..388	CDD:349788	6/21 (29%)
		LGIC_TM_anion	459..603	CDD:349851	46/194 (24%)
		TM1 helix	459..482	CDD:349851	8/22 (36%)
		TM2 helix	486..510	CDD:349851	7/23 (30%)
		TM3 helix	518..579	CDD:349851	19/104 (18%)
		TM4 helix	580..603	CDD:349851	7/22 (32%)