DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12344 and glc-2

DIOPT Version :9

Sequence 1:	NP_001286298.1	Gene:	CG12344 / 36145	FlyBaseID:	FBgn0033558	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_491470.1	Gene:	glc-2 / 172103	WormBaseID:	WBGene00001592	Length:	434	Species:	Caenorhabditis elegans

Alignment Length:	462	Identity:	117/462 - (25%)
Similarity:	205/462 - (44%)	Gaps:	66/462 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SFGLGFILMWLSEATEAHMNYTAKPRVV--LPPNYVKEIRPPSKKGS---PVIVDFSIFVVDINS 71
            ||.:..:|:.:...|....:..::..::  |..||...:|||....|   .|.|..:|.:..::.
Worm     6 SFSILLLLLLMPVVTNGEYSMQSEQEILNALLKNYDMRVRPPPANSSTEGAVNVRVNIMIRMLSK 70

  Fly    72 INVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSKIAEIATL 136
            |:|.:|::.:.:...::|::.||...:..|.....::| :|.|.::.|.||.:|...|.|....:
Worm    71 IDVVNMEYSIQLTFREQWIDPRLAYENLGFYNPPAFLT-VPHVKKSLWIPDTFFPTEKAAHRHLI 134

  Fly   137 THKFTSVTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRWSDS-GV 200
            ..:...:.:|.:..:.|::|:....:|.|..||||:|.|.|...:.|::.....:...|..| .|
Worm   135 DMENMFLRIYPDGKILYSSRISLTSSCPMRLQLYPLDYQSCNFDLVSYAHTMNDIMYEWDPSTPV 199

  Fly   201 TLNPELKLLQYNLGQPLE-------LEESDGYMPEKVGNFSRLTVYFRFERQIGHHLIQTFAPSS 258
            .|.|       .:|..|.       ...:|.......|::..|.:...|:||..::|:|.:||::
Worm   200 QLKP-------GVGSDLPNFILKNYTTNADCTSHTNTGSYGCLRMQLLFKRQFSYYLVQLYAPTT 257

  Fly   259 LVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFT--GADIPPVAYVKALDLWMAGCMLSVFAA 321
            ::|::||.|||:.|.:..|||.|.||.:||:.||.:  .|.:|||:|||.:|:|:..|...||.|
Worm   258 MIVIVSWVSFWIDLHSTAGRVALGVTTLLTMTTMQSAINAKLPPVSYVKVVDVWLGACQTFVFGA 322

  Fly   322 LAEFVVVKVLDVQYQ---------YQVNRIPKVLPMRISNMEKGQCATVASWEGGAVRSRKATQT 377
            |.|:..|...|...|         .:..|..:.|.|..:.:.:..| |..::|.......|..:.
Worm   323 LLEYAFVSYQDSVRQNDRSREKAARKAQRRREKLEMVDAEVYQPPC-TCHTFEARETFRDKVRRY 386

  Fly   378 PTTPGQTSLQGNGGPPKPARRQSLLSVAWTDTDTGVEKIMWREIDKVSRAVFPILFFVFVLLYWP 442
            .|.|...          ||:                       ||..:|.|.|:.|..|.::||.
Worm   387 FTKPDYL----------PAK-----------------------IDFYARFVVPLAFLAFNVIYWV 418

  Fly   443 ILLMKSS 449
            ..|:.|:
Worm   419 SCLIMSA 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12344	NP_001286298.1	LIC	8..441	CDD:273305	113/452 (25%)
glc-2	NP_491470.1	LIC	29..419	CDD:273305	111/431 (26%)
		Neur_chan_LBD	29..244	CDD:280998	50/222 (23%)
		Neur_chan_memb	252..417	CDD:280999	55/198 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910