Protein Alignment alka and Gabrd

DIOPT Version :10

• Sequence 1: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_001408102.1
• Gene: Gabrd / 14403
• MGIID: 95622
• Length: 483
• Species: Mus musculus
• Alignment Length: 424
• Identity: 115/424 - (27%)
• Similarity: 202/424 - (47%)
• Gaps: 38/424 - (8%)

  Fly    40 LPPNYVKEIRPPSKKGSPVIVDFSIFVVDINSINVEDMDFRVDMFIHQRWLESRLEIPDDIFEEG 104
            |...|.:..| |...|:||.|..::.|..|:.|:..:|::.:.:|:||.|.:|||.     :...
Mouse    81 LMEGYARNFR-PGIGGAPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLS-----YNHT 139

  Fly   105 DDYVTLLPEVFENFWQPDPYFLNSKIAEIATLTHKFTSVTLYKNKTVRYAARMHAIIACQMEFQL 169
            ::.:.|.....:..|.||.:.:|:|.|....:|.:...:.|..:..:.|:.|:.:.:||.|:...
Mouse   140 NETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAK 204

  Fly   170 YPMDIQVCPIYIESFSSNNQKVKLRWSDSGVTLN--PELKLLQYNLGQPLELEESDGYMPEKVGN 232
            ||:|.|.|.:.:||:..:::.:...||::...::  ..|:|.|:.:.......|...:  :..|.
Mouse   205 YPLDEQECMLDLESYGYSSEDIVYYWSENQEQIHGLDRLQLAQFTITSYRFTTELMNF--KSAGQ 267

  Fly   233 FSRLTVYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTGA- 296
            |.||:::|:..|..|.::||::.||.|:|.:||.|||:...|:|.||:|.:|.:||:.|:...|
Mouse   268 FPRLSLHFQLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSAR 332

  Fly   297 -DIPPVAYVKALDLWMAGCMLSVFAALAEFVVVKVLDVQYQYQVNRIPKVLPMRISNMEKGQCAT 360
             .:|..:.:||||::...|.:.|||||.|:.... .:..|:.:.....||...| :.|:......
Mouse   333 SSLPRASAIKALDVYFWICYVFVFAALVEYAFAH-FNADYRKKRKAKVKVTKPR-AEMDVRNAIV 395

  Fly   361 VASWEGGAVR-----SRKATQTP--------TTPGQTSLQGNGGPPKPARRQSLLSVAWTDTDTG 412
            :.|.....|.     ||:..:.|        :...:...:|...|..|...:|.|..  .|.||
Mouse   396 LFSLSAAGVSQELAISRRQGRVPGNLMGSYRSVEVEAKKEGGSRPGGPGGIRSRLKP--IDADT- 457

  Fly   413 VEKIMWREIDKVSRAVFPILFFVFVLLYWPILLM 446
                    ||..:|||||..|....::||....|
Mouse   458 --------IDIYARAVFPAAFAAVNIIYWAAYTM 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alka	NP_610619.2	LIC	8..441	CDD:455710	112/417 (27%)
Gabrd	NP_001408102.1	LGIC_ECD	97..280	CDD:475126	46/189 (24%)
		LGIC_TM_GABAAR_delta	283..>371	CDD:349857	33/88 (38%)
		TM1 helix	283..306	CDD:349857	11/22 (50%)
		TM2 helix	310..334	CDD:349857	9/23 (39%)
		TM3 helix	342..368	CDD:349857	11/26 (42%)