DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12344 and Gabra3

DIOPT Version :9

Sequence 1:	NP_001286298.1	Gene:	CG12344 / 36145	FlyBaseID:	FBgn0033558	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_001344745.1	Gene:	Gabra3 / 14396	MGIID:	95615	Length:	523	Species:	Mus musculus

Alignment Length:	468	Identity:	125/468 - (26%)
Similarity:	202/468 - (43%)	Gaps:	96/468 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 NYTAKPRVV--LPPNYVKEIRPPSKKGSPVI-VDFSIFVVDINSINVEDMDFRVDMFIHQRWLES 92
            |.|...|::  |...|...:||  ..|..|. |...|:|.....::..||::.:|:|..|.|.:.
Mouse    94 NITIFTRILDRLLDGYDNRLRP--GLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDE 156

  Fly    93 RLEIPDDIFEEGDDYVTLLP---EVFENFWQPDPYFLNSKIAEIATLTHKFTS----VTLYKNKT 150
            ||:.        |..:.:||   .:....|.||.:|.|.|    .::.|..|:    :.|..|.|
Mouse   157 RLKF--------DGPMKILPLNNLLASKIWTPDTFFHNGK----KSVAHNMTTPNKLLRLVDNGT 209

  Fly   151 VRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRWSDSGVTLNPEL-----KLLQ 210
            :.|..|:.....|.|..:.:|||:..||:...|::....:|...|: .|...:.|:     :|.|
Mouse   210 LLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTKAEVIYSWT-LGKNKSVEVAQDGSRLNQ 273

  Fly   211 YN-LGQPLELEESDGYMPEKVGNFSRLTVYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLGLDA 274
            |: ||..:..|    .:....|.:..:|.:|..:|:||:.:|||:.|..:.|:||..||||..::
Mouse   274 YDLLGHVVGTE----IIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRES 334

  Fly   275 IPGRVTLLVTCMLTLVTMFTGA--DIPPVAYVKALDLWMAGCMLSVFAALAEFVVVKVLDVQ-YQ 336
            :|.|....||.:||:.|:...|  .:|.|||..|:|.::|.|...||:||.||..|.....: :.
Mouse   335 VPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWA 399

  Fly   337 YQVNRIPKVLPMR------------------------------ISNMEKGQCATVASWEGGAVRS 371
            ::..::|:.|.|:                              .|.:.|...|..||....|:.|
Mouse   400 WEGKKVPEALEMKKKTPAAPTKKNTTFNIVGTTYPINLAKDTEFSTISKSAAAPSASSTPTAIAS 464

  Fly   372 RKATQTPTTPGQTSLQGNGGPPKPARRQSLLSVAWTDTDTGVEKIMWREIDKVSRAVFPILFFVF 436
            .|||....:|.:|.                       |...|.|     :||:||.:||:||.:|
Mouse   465 PKATYVQDSPAETK-----------------------TYNSVSK-----VDKISRIIFPVLFAIF 501

  Fly   437 VLLYWPILLMKSS 449
            .|:||...:.:.|
Mouse   502 NLVYWATYVNRES 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12344	NP_001286298.1	LIC	8..441	CDD:273305	122/458 (27%)
Gabra3	NP_001344745.1	Neur_chan_LBD	100..509	CDD:332142	122/455 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910