Protein Alignment alka and Gabra4

DIOPT Version :10

• Sequence 1: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_542154.3
• Gene: Gabra4 / 140675
• RGDID: 621670
• Length: 552
• Species: Rattus norvegicus
• Alignment Length: 526
• Identity: 136/526 - (25%)
• Similarity: 213/526 - (40%)
• Gaps: 135/526 - (25%)

  Fly    31 NYTAKPRVV--LPPNYVKEIRPPSKKGSPVI-VDFSIFVVDINSINVEDMDFRVDMFIHQRWLES 92
            |:|   |::  |...|...:||..  |.||. |...|:|.....::..:|::.:|:|..|.|::.
  Rat    47 NFT---RILDSLLDGYDNRLRPGF--GGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDK 106

  Fly    93 RLEI--PDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSKIAEIATLTHKFTS----VTLYKNKTV 151
            ||:.  |.:|....:..||       ..|.||.:|.|.|    .:::|..|:    ..:.:|.|:
  Rat   107 RLKYDGPIEILRLNNMMVT-------KVWTPDTFFRNGK----KSVSHNMTAPNKLFRIMRNGTI 160

  Fly   152 RYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRWSDSGVTLNPE---------LK 207
            .|..|:.....|.|....:|||...||:...|::....::...|     |..||         ..
  Rat   161 LYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTW-----TKGPEKSVEVPKESSS 220

  Fly   208 LLQYNL-GQPLELEESDGYMPEKVGNFSRLTVYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLG 271
            |:||:| ||.:..|.    :....|.:..:||||...|::|:.:|||:.|..:.|:||..|||:.
  Rat   221 LVQYDLIGQTVSSET----IKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWIN 281

  Fly   272 LDAIPGRVTLLVTCMLTLVTMFTGA--DIPPVAYVKALDLWMAGCMLSVFAALAEFVVVKVL-DV 333
            .:::|.|....:|.:||:.|:...|  .:|.|:|..|:|.::|.|...||:||.||..|... ::
  Rat   282 KESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNI 346

  Fly   334 QYQYQVNRIPK---------VLPMRIS-----------NMEKGQCATVASWEGGAVRSR------ 372
            |.|....:|.|         ||..:.:           ||.|...|.|.|  ...|.||
  Rat   347 QMQKAKKKISKPPPEVPAAPVLKEKHTETSLQNTHANLNMRKRTNALVHS--ESDVNSRTEVGNH 409

  Fly   373 --KAT----QTPTTPGQTSLQGNGGP------------------------------PKPARRQS- 400
              |.|    .:.||| :..|..:..|                              |.|.|..|
  Rat   410 SSKTTAAQESSETTP-KAHLASSPNPFSRANAAETISAAARGLSSAASPSPHGTLQPAPLRSASA 473

  Fly   401 -------LLSVAWTDTDTGVEKIM---------------WREIDKVSRAVFPILFFVFVLLYWPI 443
                   |..:..|...|||...:               ..:|||.:|.:||:.|..|.::||.:
  Rat   474 RPAFGARLGRIKTTVNTTGVPGNVSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVV 538

  Fly   444 LLMKSS 449
            .|.|.:
  Rat   539 YLSKDT 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alka	NP_610619.2	LIC	8..441	CDD:455710	132/516 (26%)
Gabra4	NP_542154.3	LIC	13..539	CDD:455710	134/519 (26%)
		LGIC_ECD_GABAAR_A4	57..255	CDD:349838	56/219 (26%)
		Cys-loop	172..186	CDD:349838	5/13 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..436		20/85 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	448..470		2/21 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	486..513		4/26 (15%)