DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12344 and Gabra4

DIOPT Version :9

Sequence 1:	NP_001286298.1	Gene:	CG12344 / 36145	FlyBaseID:	FBgn0033558	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_542154.3	Gene:	Gabra4 / 140675	RGDID:	621670	Length:	552	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	136/526 - (25%)
Similarity:	213/526 - (40%)	Gaps:	135/526 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 NYTAKPRVV--LPPNYVKEIRPPSKKGSPVI-VDFSIFVVDINSINVEDMDFRVDMFIHQRWLES 92
            |:|   |::  |...|...:||..  |.||. |...|:|.....::..:|::.:|:|..|.|::.
  Rat    47 NFT---RILDSLLDGYDNRLRPGF--GGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDK 106

  Fly    93 RLEI--PDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSKIAEIATLTHKFTS----VTLYKNKTV 151
            ||:.  |.:|....:..||       ..|.||.:|.|.|    .:::|..|:    ..:.:|.|:
  Rat   107 RLKYDGPIEILRLNNMMVT-------KVWTPDTFFRNGK----KSVSHNMTAPNKLFRIMRNGTI 160

  Fly   152 RYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRWSDSGVTLNPE---------LK 207
            .|..|:.....|.|....:|||...||:...|::....::...|     |..||         ..
  Rat   161 LYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTW-----TKGPEKSVEVPKESSS 220

  Fly   208 LLQYNL-GQPLELEESDGYMPEKVGNFSRLTVYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLG 271
            |:||:| ||.:..|.    :....|.:..:||||...|::|:.:|||:.|..:.|:||..|||:.
  Rat   221 LVQYDLIGQTVSSET----IKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWIN 281

  Fly   272 LDAIPGRVTLLVTCMLTLVTMFTGA--DIPPVAYVKALDLWMAGCMLSVFAALAEFVVVKVL-DV 333
            .:::|.|....:|.:||:.|:...|  .:|.|:|..|:|.::|.|...||:||.||..|... ::
  Rat   282 KESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNI 346

  Fly   334 QYQYQVNRIPK---------VLPMRIS-----------NMEKGQCATVASWEGGAVRSR------ 372
            |.|....:|.|         ||..:.:           ||.|...|.|.|  ...|.||
  Rat   347 QMQKAKKKISKPPPEVPAAPVLKEKHTETSLQNTHANLNMRKRTNALVHS--ESDVNSRTEVGNH 409

  Fly   373 --KAT----QTPTTPGQTSLQGNGGP------------------------------PKPARRQS- 400
              |.|    .:.||| :..|..:..|                              |.|.|..|
  Rat   410 SSKTTAAQESSETTP-KAHLASSPNPFSRANAAETISAAARGLSSAASPSPHGTLQPAPLRSASA 473

  Fly   401 -------LLSVAWTDTDTGVEKIM---------------WREIDKVSRAVFPILFFVFVLLYWPI 443
                   |..:..|...|||...:               ..:|||.:|.:||:.|..|.::||.:
  Rat   474 RPAFGARLGRIKTTVNTTGVPGNVSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVV 538

  Fly   444 LLMKSS 449
            .|.|.:
  Rat   539 YLSKDT 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12344	NP_001286298.1	LIC	8..441	CDD:273305	132/516 (26%)
Gabra4	NP_542154.3	LIC	13..539	CDD:273305	134/519 (26%)
		Neur_chan_LBD	49..256	CDD:280998	60/231 (26%)
		Neur_chan_memb	263..536	CDD:280999	68/275 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..436		20/85 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..470		2/21 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..513		4/26 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910