Protein Alignment alka and CHRNG

DIOPT Version :10

• Sequence 1: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_005190.4
• Gene: CHRNG / 1146
• HGNCID: 1967
• Length: 517
• Species: Homo sapiens
• Alignment Length: 349
• Identity: 73/349 - (20%)
• Similarity: 137/349 - (39%)
• Gaps: 60/349 - (17%)

  Fly    40 LPPNYVKEIRPPSKKGSPVIVDFSIFVVDINSINVEDMDFRVDMFIHQRWLESRLE-IPDDIFEE 103
            |..||...:||..:....|.|...:.:.::.|:|..:.....:::|..:|.:.||. .|.|.  |
Human    33 LMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDY--E 95

  Fly   104 GDDYVTLLPEVFENFWQPDPYFLNS--KIAEIATLTHKFTSVTLYKNKTVRYAARMH----AII- 161
            | .:|..:|...  .|:||....|:  .:.|:|          ||.|..|.....::    ||.
Human    96 G-LWVLRVPSTM--VWRPDIVLENNVDGVFEVA----------LYCNVLVSPDGCIYWLPPAIFR 147

  Fly   162 -ACQMEFQLYPMDIQVCPIYIES--FSSNNQKVKLRWSD----SGVTLNPEL------KLLQYNL 213
             ||.:....:|.|.|.|.:..:|  :|:|...::|...|    ..:.::||.      ..:|:..
Human   148 SACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAFTENGEWAIQHRP 212

  Fly   214 GQPLELEESDGYMPEKVGNFSRLTVYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLGLDAIPGR 278
            .:.|    .|...|.:.....::..|...:|:...::|...||..|:..::....:|...|...:
Human   213 AKML----LDPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQK 273

  Fly   279 VTLLVTCML--TLVTMFTGADIPPVAYV-----KALDLWMAGCMLSVFAALAEFVVVKV-LDVQY 335
            .|:.:..:|  |:........:|..:..     |.|...:...:|.|..|:   ||:.| |...:
Human   274 CTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAV---VVLNVSLRSPH 335

  Fly   336 QYQVNR---------IPKVLPMRI 350
            .:.:.|         :|::|.|.:
Human   336 THSMARGVRKVFLRLLPQLLRMHV 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alka	NP_610619.2	LIC	8..441	CDD:455710	73/349 (21%)
CHRNG	NP_005190.4	LGIC_ECD_nAChR_G	49..241	CDD:349830	45/210 (21%)
		Cys-loop	150..164	CDD:349830	4/13 (31%)
		Neur_chan_memb	248..492	CDD:460753	22/115 (19%)