Protein Alignment alka and Gabra5

DIOPT Version :10

• Sequence 1: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_795916.1
• Gene: Gabra5 / 110886
• MGIID: 95617
• Length: 463
• Species: Mus musculus
• Alignment Length: 454
• Identity: 125/454 - (27%)
• Similarity: 209/454 - (46%)
• Gaps: 46/454 - (10%)

  Fly    11 ISFGLGFILMWLSEA-TEAHMNYTAKPRVV--LPPNYVKEIRPP-SKKGSPVIVDFSIFVVDINS 71
            :|...||..|..|.. .|.:.|.|...|::  |...|...:||. .::.:.|..|  |:|.....
Mouse    24 LSSHFGFSQMPTSSVQDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTD--IYVTSFGP 86

  Fly    72 INVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSKIAEIATL 136
            ::..:|::.:|:|..|.|.:.||.     |:.....:.|...:....|.||.:|.|.|    .::
Mouse    87 VSDTEMEYTIDVFFRQSWKDERLR-----FKGPMQRLPLNNLLASKIWTPDTFFHNGK----KSI 142

  Fly   137 THKFTS----VTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRWSD 197
            .|..|:    :.|..:.|:.|..|:.....|.|:.:.:|||...||:...|::..|.:|...|::
Mouse   143 AHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTN 207

  Fly   198 ----SGVTLNPELKLLQYNL-GQPLELEESDGYMPEKVGNFSRLTVYFRFERQIGHHLIQTFAPS 257
                |.|......:|.||:| ||.:..|.    :....|.::.:|.:|..:|:||:.:|||:.|.
Mouse   208 GSTKSVVVAEDGSRLNQYHLMGQTVGTEN----ISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPC 268

  Fly   258 SLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTGA--DIPPVAYVKALDLWMAGCMLSVFA 320
            .:.|:||..||||..:::|.|....||.:||:.|:...|  .:|.|||..|:|.::|.|...||:
Mouse   269 IMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFS 333

  Fly   321 ALAEFVVVKVLDVQ-YQYQVNRIPKVLPMRISNMEKGQCATVASWEGGAVRSRKATQTPTTPGQT 384
            ||.||..|.....: :.:...:     .:..:.::|.:...:.:....|..:.|.|..|..|.:.
Mouse   334 ALIEFATVNYFTKRGWAWDGKK-----ALEAAKIKKKERELILNKSTNAFTTGKLTHPPNIPKEQ 393

  Fly   385 SLQGNGGPPKPARRQSLLSVAWTDTDTGVEKIMWR---EIDKVSRAVFPILFFVFVLLYWPILL 445
                   ||........:|:..::..|...|..:.   :|||:||.||||||..|.|:||...|
Mouse   394 -------PPAGTANAPTVSIKASEEKTAESKKTYNSISKIDKMSRIVFPILFGTFNLVYWATYL 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alka	NP_610619.2	LIC	8..441	CDD:455710	122/448 (27%)
Gabra5	NP_795916.1	LIC	15..449	CDD:455710	124/451 (27%)
		LGIC_ECD_GABAAR_A5	58..256	CDD:349839	51/212 (24%)
		Cys-loop	173..187	CDD:349839	5/13 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	387..408		5/27 (19%)