Protein Alignment alka and gabra5

DIOPT Version :10

• Sequence 1: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: XP_004911866.1
• Gene: gabra5 / 100494208
• XenbaseID: XB-GENE-980292
• Length: 475
• Species: Xenopus tropicalis
• Alignment Length: 476
• Identity: 126/476 - (26%)
• Similarity: 209/476 - (43%)
• Gaps: 90/476 - (18%)

  Fly    17 FILMWLSEATEAHMNY-TAKP-------------RVV--LPPNYVKEIRPP-SKKGSPVIVDFSI 64
            |..::|:.||...|:. ||.|             |::  |...|...:||. .::.:.|..|  |
 Frog    21 FFCLFLALATNFSMSQTTAAPVKEDTNDNITIFTRILDGLLDGYDNRLRPGLGERITQVKTD--I 83

  Fly    65 FVVDINSINVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSK 129
            :|.....::..:|::.:|:|..|.|.:.||     .|:.....:.|...:....|.||.:|.|.|
 Frog    84 YVTSFGPVSDTEMEYTIDVFFRQSWKDERL-----CFQGPMPRLPLNNLLASKIWTPDTFFHNGK 143

  Fly   130 IAEIATLTHKFTS----VTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQK 190
                .::.|..|:    :.|..:.|:.|..|:.....|.|:.:.:|||...||:...|::..|.:
 Frog   144 ----KSIAHNITTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSE 204

  Fly   191 VKLRWSD----SGVTLNPELKLLQYNL-GQPLELEESDGYMPEKVGNFSRLTVYFRFERQIGHHL 250
            ::..|::    |.|......:|.||:| ||.:..|.    :....|.::.:|.:|..:|:||:.:
 Frog   205 LRYEWTNITDKSVVVAEDGSRLNQYHLIGQTVGTEN----ISTSTGEYTVMTAHFHLKRKIGYFV 265

  Fly   251 IQTFAPSSLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTGA--DIPPVAYVKALDLWMAG 313
            |||:.|..:.|:||..||||..:::|.|....||.:||:.|:...|  .:|.|||..|:|.::|.
 Frog   266 IQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAV 330

  Fly   314 CMLSVFAALAEFVVVKVLDVQYQYQVNRIPKVLPMRISNMEKGQCATVASWEG----GAVRSRKA 374
            |...||:||.||..|       .|...|                   ..:|:|    .|.:.:|.
 Frog   331 CYAFVFSALIEFATV-------NYFTKR-------------------SWAWDGKKALEAAKIKKK 369

  Fly   375 TQTPTTPGQTSLQGNGG--PPKPARRQSLLS----------VAWTDTDTGVEKIMWR---EIDKV 424
            .|  .:.|:..:....|  |..|...:.|.|          :..|:......|..:.   :|||:
 Frog   370 EQ--ESLGRKPINSYSGRIPYTPNMSKDLTSSVIANAASIHMKTTEEKCAESKKTYNSVSKIDKM 432

  Fly   425 SRAVFPILFFVFVLLYWPILL 445
            ||.|||::|..|.|:||...|
 Frog   433 SRIVFPVMFGTFNLVYWATYL 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alka	NP_610619.2	LIC	8..441	CDD:455710	123/470 (26%)
gabra5	XP_004911866.1	LIC	25..452	CDD:455710	124/469 (26%)
		LGIC_ECD_GABAAR_A5	62..260	CDD:349839	50/212 (24%)
		Cys-loop	177..191	CDD:349839	5/13 (38%)