Protein Alignment alka and gabra2

DIOPT Version :10

• Sequence 1: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: XP_002933509.2
• Gene: gabra2 / 100170583
• XenbaseID: XB-GENE-1000398
• Length: 451
• Species: Xenopus tropicalis
• Alignment Length: 461
• Identity: 126/461 - (27%)
• Similarity: 206/461 - (44%)
• Gaps: 73/461 - (15%)

  Fly    18 ILMWLSEA--------TEAHMNYTAKPRVV--LPPNYVKEIRPPSKKGSPVI-VDFSIFVVDINS 71
            :::|.|.:        .:|..|.|...|::  |...|...:||  ..|..|. |...|:|.....
 Frog    18 LVLWESSSQVLGDTVDNDAKNNITIFTRILDRLLDGYDNRLRP--GLGDRVTEVHTDIYVTSFGP 80

  Fly    72 INVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDYVTLLPEVFEN-FWQPDPYFLNSK--IAEI 133
            ::..||::.:|:|..|.|.:.||..      :|..::..|..:..| .|.||.:|.|.|  ||..
 Frog    81 VSDTDMEYTIDVFFRQNWQDERLRF------KGPMHILRLNNLMANKIWTPDTFFHNGKKSIAHN 139

  Fly   134 ATLTHKFTSVTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRW--- 195
            .|:.:|.  :.:..:.|:.|..|:.....|.|..:.:|||...||:...|::....:|...|
 Frog   140 MTMPNKL--LRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHACPLKFGSYAYTTSEVTYVWTRN 202

  Fly   196 SDSGVTLNPE-LKLLQYNLGQPLELEESDGYMPEKVGNFSRLTVYFRFERQIGHHLIQTFAPSSL 259
            :...|.:.|: .:|.||.|...|..:|:   :....|.::.:|.:|..:|:||:.:|||:.|..:
 Frog   203 ATESVVVAPDGSRLNQYVLLGHLVGKET---IKSSTGEYTVMTTHFHLKRKIGYFVIQTYLPCIM 264

  Fly   260 VVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTGA--DIPPVAYVKALDLWMAGCMLSVFAAL 322
            .|:||..||||..:::|.|....||.:||:.|:...|  .:|.|||..|:|.::|.|...||:||
 Frog   265 TVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSAL 329

  Fly   323 AEFVVV-------------KVLDVQYQYQVNRIPKVLPMRISNMEKGQCATVASWEGGAVRSRKA 374
            .||..|             .|::.:.:.:.:.|.|         .......||::   |....|.
 Frog   330 IEFATVNYFTKRGWAWDGKSVVNDKKKEKASVIKK---------NNAYAVAVANY---APNITKD 382

  Fly   375 TQTPTTPGQTSLQGNGGPPKPARRQSLLSVAWTDTDTGVEKIMWREIDKVSRAVFPILFFVFVLL 439
            :..||.....:...|...|:.|::          |...|.|     ||::||.|||:||..|.|:
 Frog   383 SALPTISKSATADPNKAKPQEAKK----------TFNSVSK-----IDRMSRIVFPLLFGTFNLV 432

  Fly   440 YWPILL 445
            ||...|
 Frog   433 YWATYL 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alka	NP_610619.2	LIC	8..441	CDD:455710	123/455 (27%)
gabra2	XP_002933509.2	LIC	12..437	CDD:455710	125/458 (27%)
		LGIC_ECD_GABAAR_A2	48..250	CDD:349836	54/214 (25%)
		Cys-loop	167..181	CDD:349836	5/13 (38%)