Protein Alignment alka and gabra2a

DIOPT Version :10

• Sequence 1: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: XP_009305482.1
• Gene: gabra2a / 100150704
• ZFINID: ZDB-GENE-141216-16
• Length: 451
• Species: Danio rerio
• Alignment Length: 451
• Identity: 130/451 - (28%)
• Similarity: 206/451 - (45%)
• Gaps: 50/451 - (11%)

  Fly    17 FILMWLSEATEAHM--------NYTAKPRVV--LPPNYVKEIRPPSKKGSPVI-VDFSIFVVDIN 70
            |:|:.....:||.:        |.|...|::  |...|...:||  ..|..|. |...|:|....
Zfish    16 FLLVLWRACSEAEVSGSDAFKNNITLFTRILDRLLDGYDNRLRP--GLGDRVTEVKTDIYVTSFG 78

  Fly    71 SINVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSK--IAEI 133
            .::..||::.||:|..|||.:.||:     |....:.:.|...:....|.||.:|.|.|  :|..
Zfish    79 PVSDTDMEYTVDVFFRQRWTDERLK-----FHGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHN 138

  Fly   134 ATLTHKFTSVTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRWSDS 198
            .|:.:|.  :.:.:|.|:.|..|:.....|.|..:.:|||...||:...|::....:|...|: .
Zfish   139 MTMPNKL--LRIMENGTLLYTMRLTVQAECPMHLEDFPMDFHSCPLKFGSYAYTLTEVTYVWT-R 200

  Fly   199 GVTLNPEL-----KLLQYNL-GQPLELEESDGYMPEKVGNFSRLTVYFRFERQIGHHLIQTFAPS 257
            ..||:.|:     :|.||:| ||.:..|.    :....|.::.:|.:|..:|:||:.:|||:.|.
Zfish   201 NATLSVEVAPDGSRLNQYDLMGQTVGKET----IKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPC 261

  Fly   258 SLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTGA--DIPPVAYVKALDLWMAGCMLSVFA 320
            .:.|:||..||||..:::|.|....||.:||:.|:...|  .:|.|||..|:|.::|.|...||:
Zfish   262 IMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFS 326

  Fly   321 ALAEFVVVKVLDVQ-YQYQVNRIPKVLPMRISNMEKGQCATVASWEGGAVRSRKATQTPTTPGQT 384
            ||.||..|.....: :.:....|........|.|:|.....||. ...|....|.:..||.
Zfish   327 ALIEFATVNYFTKRGWAWDGKSIVNDKKKETSVMKKNNAYAVAV-ANYAPHIAKDSALPTV---- 386

  Fly   385 SLQGNGGPPKPARRQSLLSVAWTDTDTGVEKIMWREIDKVSRAVFPILFFVFVLLYWPILL 445
               .....|:|::.|.:.... ..|...|.|     ||::||.:||:||..|.|:||...|
Zfish   387 ---SKSATPEPSKAQPVAKET-KKTFNSVSK-----IDRMSRIIFPVLFGSFNLVYWATYL 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alka	NP_610619.2	LIC	8..441	CDD:455710	127/445 (29%)
gabra2a	XP_009305482.1	LIC	17..437	CDD:455710	128/447 (29%)
		LGIC_ECD_GABAAR_A2	47..249	CDD:349836	57/215 (27%)
		Cys-loop	166..180	CDD:349836	5/13 (38%)