Protein Alignment CG12325 and Pwp2

DIOPT Version :10

• Sequence 1: NP_610618.1
• Gene: CG12325 / 36144
• FlyBaseID: FBgn0033557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_001162124.1
• Gene: Pwp2 / 690297
• RGDID: 1582817
• Length: 920
• Species: Rattus norvegicus
• Alignment Length: 945
• Identity: 442/945 - (46%)
• Similarity: 630/945 - (66%)
• Gaps: 48/945 - (5%)

  Fly     1 MKFSYKFSNLLGTIYRNGNLVFTPDGNSVISPVGNRITVYDLKNNKSRTLSLESRYNYTNIALSP 65
            |||:|:|||||||:||.|||.|:.||||||||||||:||:|||||:|.||.|.::||...:.|||
  Rat     1 MKFAYRFSNLLGTVYRCGNLNFSRDGNSVISPVGNRVTVFDLKNNRSDTLPLATKYNIKCVGLSP 65

  Fly    66 DGSLLIAVNEKGEAQLISMMSCTVIHRHKFQTGVQCICFSPNGAFFAVAVQNVVLIFCAPGEITG 130
            ||.|.|.|:|.|.|.|:|::..:|:|...|:..|..:.|||:|..|.:...|:..::.|||: ..
  Rat    66 DGRLAIIVDEGGAALLVSLVCRSVLHHFHFKGSVHSVSFSPDGRKFVITKGNIAQMYHAPGK-KR 129

  Fly   131 EYNPFVLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKIVAINYTKNFRTYNLSGHTDAIVAC 195
            |:|.|||.:.:.|.:|:.|.:||:.||:...:|.:|.||.:.......|...|.||||.||||||
  Rat   130 EFNAFVLDKTYFGPYDETTCIDWTDDSKCFVVGSKDMSTWVFGAERWDNLIYYALSGHKDAIVAC 194

  Fly   196 FFEANSLHLNTISRNGQLCLWECSLAPSDLEDAERPKIAPP--------QRKKEKKAVSDNESED 252
            |||:|||.|.::|::|.||:|:|...|..|      ::..|        ||:||::...|.|.|.
  Rat   195 FFESNSLDLYSLSQDGALCVWQCDTPPEGL------RLKAPRGWKADILQREKEEEEEEDEEGEG 253

  Fly   253 DVENVVEKDALKEESTKEAEDVNHIKNEDETKSHPFFYKKITRHYLADEPRKEQRDVQLTAANYN 317
            :.|..:...|:..|.    |.|..:|           |.::.:::|    .||.....||||.|:
  Rat   254 NRETTIRGKAVPAEQ----ERVGKVK-----------YSRLAKYFL----NKEGDFNNLTAAAYH 299

  Fly   318 TRTKVLVVAFSSGAFYLYELPDVNMIHSLSISDYPISAALFNCTGDWVALASREIGQLLVWEWQS 382
            .:|.:||..|:||.|:|:|||:.|:||||||||..:::...|.:|||:|.....:||||||||||
  Rat   300 KKTHLLVTGFASGIFHLHELPEFNLIHSLSISDQRVASVAINSSGDWIAFGCSGLGQLLVWEWQS 364

  Fly   383 EQYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNK 447
            |.|::|||||.:.|..:|||.|||:|.|||:|.|||:|||.|.|||||.:||:|||||:.|:...
  Rat   365 ESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTLTEHSSGVTGVTFTATG 429

  Fly   448 KFLVSSSLDGTVRAFDVNRYRNFRTFTSPNPAQFSCVAVDYSGELVVAGGQDVFDIFLWSVKTGK 512
            ..:|:|||||||||:|::|||||||||||.|.||||||||.|||:|.||.||.|:||:||::||:
  Rat   430 HVIVTSSLDGTVRAYDLHRYRNFRTFTSPRPTQFSCVAVDSSGEIVSAGAQDSFEIFVWSMQTGR 494

  Fly   513 LLEIISGHEGPVVSIAFSPVATSSTLVSGSWDKTVKIWNCLESNSEHETIDAVSDVTNVTFSPSG 577
            ||:::||||||:..:.|:|:  .|.|.|.||||||::|:..:|....||:...|||..||:.|.|
  Rat   495 LLDVLSGHEGPISGLCFNPM--KSILASASWDKTVRLWDMFDSWRTKETLSLTSDVLAVTYRPDG 557

  Fly   578 EEIAVATLSGNITIFDIKSAGQVTTIEGRNDLSAGRLETDIITARKNAQANYFSTIEYSADGECI 642
            .|:|||||:..||.:|.::|.||.:||||:||..||.|.|.|||:.:|:...|:|:.|||||:.|
  Rat   558 AELAVATLNSQITFWDPENAVQVGSIEGRHDLKTGRKELDKITAKHSAKGKAFTTVCYSADGQNI 622

  Fly   643 LAAGKSANICIYHVREAILLKKFEITQNHSLDGLNDFISRKHLSEFGNMALVEEREELEGGRVAI 707
            ||.|.|..:|:|||||.||:|:||::.|.|||.:.:|::|:.::||||:||:::....|.| |||
  Rat   623 LAGGMSKFVCLYHVREQILVKRFELSCNFSLDAMEEFLNRRKMTEFGNLALIDQDAGEENG-VAI 686

  Fly   708 RLPGVQRGDMSSRRFQQEVRVFSVKFSPTGQAFAAAGTEGLCIYALDKGVVFDPFDLSLEVTPKA 772
            .||||::||||||.|:.|:||.|::|||||:.:||..||||.|::||..::||||:|...|||..
  Rat   687 PLPGVRKGDMSSRHFKPEIRVTSLRFSPTGRCWAATSTEGLLIFSLDAQMLFDPFELDTSVTPGR 751

  Fly   773 VHESLKQQNYTKALVMSLKLNEPNLIALVLERVPYKDVELVCADLSPEFAQRLLQQLARQLQSTP 837
            :.|:|:|:.:|:|::|:.:|||..|....||.||..::|:|.|.|...:..::|:.||...:.:.
  Rat   752 IREALRQREFTRAILMAFRLNEKKLAQEALEAVPQNEIEVVSASLPELYVVKVLEFLAASFEESR 816

  Fly   838 HIEFYLQWSCCLLTKHGNQDGVFQHTGLLA-----LHEVLSRKYEMLNKICDYNKYTLKVLLDRA 897
            |:||||.|:..||..||.:  :....|.|.     |.:.|.|..:.::|:||:|:|.::..|..:
  Rat   817 HLEFYLIWTQKLLMSHGQR--LKSRAGQLLPVVQFLQKGLQRHLDDISKLCDWNRYNIQYALAVS 879

  Fly   898 DKLEQKNEGKPNATEED---SDEEML-LIRSKDDE 928
            .:...|...:|..||||   |||:.| |:|:.::|
  Rat   880 KQRGMKRTLEPVDTEEDTDASDEDSLHLLRAAEEE 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12325	NP_610618.1	WD40	<20..424	CDD:441893	179/411 (44%)
		WD40 repeat	59..94	CDD:293791	15/34 (44%)
		WD40 repeat	99..143	CDD:293791	15/43 (35%)
		WD40 repeat	149..187	CDD:293791	12/37 (32%)
		WD40 repeat	192..247	CDD:293791	24/62 (39%)
		WD40	306..657	CDD:441893	196/350 (56%)
		WD40 repeat	353..391	CDD:293791	19/37 (51%)
		WD40 repeat	397..433	CDD:293791	23/35 (66%)
		WD40 repeat	438..474	CDD:293791	22/35 (63%)
		WD40 repeat	482..518	CDD:293791	23/35 (66%)
		WD40 repeat	524..557	CDD:293791	13/32 (41%)
		WD40 repeat	565..594	CDD:293791	15/28 (54%)
		Utp12	793..895	CDD:461125	34/106 (32%)
Pwp2	NP_001162124.1	WD40 repeat	17..51	CDD:293791	25/33 (76%)
		WD40 repeat	59..93	CDD:293791	15/33 (45%)
		WD40	<61..446	CDD:441893	176/410 (43%)
		WD40 repeat	101..142	CDD:293791	14/41 (34%)
		WD40 repeat	148..186	CDD:293791	12/37 (32%)
		WD40 repeat	191..260	CDD:293791	28/74 (38%)
		WD40	293..637	CDD:441893	196/345 (57%)
		WD40 repeat	294..329	CDD:293791	19/34 (56%)
		WD40 repeat	335..373	CDD:293791	19/37 (51%)
		WD40 repeat	379..415	CDD:293791	23/35 (66%)
		WD40 repeat	420..456	CDD:293791	22/35 (63%)
		WD40 repeat	464..500	CDD:293791	23/35 (66%)
		WD40 repeat	506..543	CDD:293791	15/38 (39%)
		WD40 repeat	548..603	CDD:293791	30/54 (56%)
		WD40 repeat	610..634	CDD:293791	13/23 (57%)
		WD40 repeat	653..699	CDD:293791	23/46 (50%)
		WD40 repeat	707..748	CDD:293791	21/40 (53%)
		Utp12	772..877	CDD:461125	34/106 (32%)