Protein Alignment CG12325 and pwp2h

DIOPT Version :10

• Sequence 1: NP_610618.1
• Gene: CG12325 / 36144
• FlyBaseID: FBgn0033557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_998212.1
• Gene: pwp2h / 266990
• ZFINID: ZDB-GENE-021031-3
• Length: 937
• Species: Danio rerio
• Alignment Length: 956
• Identity: 441/956 - (46%)
• Similarity: 630/956 - (65%)
• Gaps: 50/956 - (5%)

  Fly     1 MKFSYKFSNLLGTIYRNGNLVFTPDGNSVISPVGNRITVYDLKNNKSRTLSLESRYNYTNIALSP 65
            |||:||||||||..||.||:.|:.:|:||||||||||:|:|||||||.||.:.:..|.....:||
Zfish     1 MKFAYKFSNLLGAFYRQGNISFSKNGDSVISPVGNRISVFDLKNNKSETLPVSTSKNIACFDISP 65

  Fly    66 DGSLLIAVNEKGEAQLISMMSCTVIHRHKFQTGVQCICFSPNGAFFAVAVQNVVLIFCAPGEITG 130
            ||:|.|.::|.|.|.|:|:::..|:|.|.|...|..:.|||:|..|.|..:||.|::.|||. ..
Zfish    66 DGNLAILIDEDGAAILVSLVTRAVLHHHHFHNPVHNVSFSPDGRKFVVTKENVALMYHAPGR-NK 129

  Fly   131 EYNPFVLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKIVAINYTKNFRTYNLSGHTDAIVAC 195
            |:|.|.|.:.|.|.||::|.:||:.||:..|:|.:|.:|.|.......|...|:|.||.|.||.|
Zfish   130 EFNAFALNKTFYGPFDEMTCIDWTDDSKCFAVGSKDMTTWIFGAERWANLIYYSLGGHKDIIVGC 194

  Fly   196 FFEANSLHLNTISRNGQLCLWECSLAPSDLEDAER-PKIAPPQRKKEKKAVSDNESEDDVENVVE 259
            |||.:||.:.|:|:.|.||:||   :.:|||...: ||.| .:::||:|.:...|.|:|..|.:|
Zfish   195 FFEKDSLDMYTVSQEGTLCIWE---SDTDLEGLRKGPKYA-ERKEKEQKKLRVLEMEEDEANDIE 255

  Fly   260 KDALKEE--------STKEAEDVNHIKNEDETKSHPFFYKKITRHYLADEPRKEQRDVQLTAANY 316
            .....||        |.:..|:|..|||        ..|.:.:::|.    .||....:||||.:
Zfish   256 IMGEDEETRGDVIKGSAETPEEVEGIKN--------VRYLQKSKYYF----NKEGDFNKLTAAAF 308

  Fly   317 NTRTKVLVVAFSSGAFYLYELPDVNMIHSLSISDYPISAALFNCTGDWVALASREIGQLLVWEWQ 381
            :.||.:||..|:||||:|:|||..::||||||||..|||...|.||||::.....:|||||||||
Zfish   309 HKRTHILVTGFASGAFHLHELPGFDLIHSLSISDQRISAISLNPTGDWISFGCSGLGQLLVWEWQ 373

  Fly   382 SEQYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRN 446
            ||.|:.|||||.:.|..:|||.|||::||||:|.|||:|||.|..|||||:||:||||.:.|:.:
Zfish   374 SESYVFKQQGHFNNMNSLAYSPDGQYLATGGDDGKVKVWNTNSGLCFVTFTEHSSGVTEVAFTSS 438

  Fly   447 KKFLVSSSLDGTVRAFDVNRYRNFRTFTSPNPAQFSCVAVDYSGELVVAGGQDVFDIFLWSVKTG 511
            ...:||:||||||||||::|||||||.|||.|||||.:|||.|||||.||.||.|:|||||::||
Zfish   439 GFVVVSASLDGTVRAFDLHRYRNFRTMTSPRPAQFSSLAVDGSGELVCAGSQDSFEIFLWSMQTG 503

  Fly   512 KLLEIISGHEGPVVSIAFSPVATSSTLVSGSWDKTVKIWNCLESNSEHETIDAVSDVTNVTFSPS 576
            :|||::|||||||.::.||||  .|.|.|.||||||::|:.|:|....||:...||...||:.|:
Zfish   504 RLLEVLSGHEGPVSNLCFSPV--QSVLASVSWDKTVRLWDMLDSWQTKETLQLTSDGLAVTYHPN 566

  Fly   577 GEEIAVATLSGNITIFDIKSAGQVTTIEGRNDLSAGRLETDIITARKNAQANYFSTIEYSADGEC 641
            |.|:|||:|.|.||.::.::..|..:|.||:||..||.|::.|||:::|:...|:|:.||||||.
Zfish   567 GMELAVASLDGEITFWNPQTGRQTGSITGRHDLQMGRKESEKITAKQSAKGKSFTTLCYSADGES 631

  Fly   642 ILAAGKSANICIYHVREAILLKKFEITQNHSLDGLNDFISRKHLSEFGNMALVEEREELEGGRVA 706
            ||..|||..:|||:::|.:|:|||||:.|.|||.:.:|:.|:.::|||:::||:|... :|..|.
Zfish   632 ILTGGKSKFVCIYNIKEHLLMKKFEISCNLSLDAMEEFLDRRKMTEFGSLSLVDEGTG-DGNGVE 695

  Fly   707 IRLPGVQRGDMSSRRFQQEVRVFSVKFSPTGQAFAAAGTEGLCIYALDKGVVFDPFDLSLEVTPK 771
            :.||||::||||:|.|:.|:.|.|::|||||:::|||.||||.||:||..:||||:||.::|||.
Zfish   696 LSLPGVKKGDMSTRCFKPEISVSSLRFSPTGRSWAAASTEGLLIYSLDAALVFDPYDLDIDVTPT 760

  Fly   772 AVHESLKQQNYTKALVMSLKLNEPNLIALVLERVPYKDVELVCADLSPEFAQRLLQQLARQLQST 836
            ::.:.:.::.:..|:::..:|||..||..|||.:|:..:.:||:.|...:..:||..:|..|:.:
Zfish   761 SIRQQITKKEWASAILLFFRLNEILLIREVLEAIPFDQITVVCSSLPDVYVDKLLNFVASTLEKS 825

  Fly   837 PHIEFYLQWSCCLLTKHG----NQDGVFQHTGLLALHEVLSRKYEMLNKICDYNKYTLKVLLDRA 897
            .|::|||.|:.||||.||    |:.|....| :..|.:.:.|..:.|:|:||:|.|.::.    |
Zfish   826 NHLQFYLTWAQCLLTLHGQKLKNRPGFVLPT-VQQLLKSIQRHSDDLSKLCDWNIYNIRY----A 885

  Fly   898 DKLEQKNEGKPNATE------EDSDEEMLLIRSKDDENGQAQFSDE 937
            ..|.::...|..|:|      |||.|.|      |.|..:...::|
Zfish   886 AALAKQRGLKRTASEIYGAEKEDSSEAM------DSEGDEENVTNE 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12325	NP_610618.1	WD40	<20..424	CDD:441893	184/412 (45%)
		WD40 repeat	59..94	CDD:293791	13/34 (38%)
		WD40 repeat	99..143	CDD:293791	18/43 (42%)
		WD40 repeat	149..187	CDD:293791	13/37 (35%)
		WD40 repeat	192..247	CDD:293791	24/55 (44%)
		WD40	306..657	CDD:441893	199/350 (57%)
		WD40 repeat	353..391	CDD:293791	22/37 (59%)
		WD40 repeat	397..433	CDD:293791	23/35 (66%)
		WD40 repeat	438..474	CDD:293791	22/35 (63%)
		WD40 repeat	482..518	CDD:293791	24/35 (69%)
		WD40 repeat	524..557	CDD:293791	17/32 (53%)
		WD40 repeat	565..594	CDD:293791	14/28 (50%)
		Utp12	793..895	CDD:461125	37/105 (35%)
pwp2h	NP_998212.1	WD40	<20..219	CDD:441893	90/202 (45%)
		WD40 repeat	101..142	CDD:293791	17/41 (41%)
		WD40 repeat	148..280	CDD:293791	50/135 (37%)
		WD40	303..647	CDD:441893	199/345 (58%)
		WD40 repeat	345..383	CDD:293791	22/37 (59%)
		WD40 repeat	389..425	CDD:293791	23/35 (66%)
		WD40 repeat	430..466	CDD:293791	22/35 (63%)
		WD40 repeat	474..510	CDD:293791	24/35 (69%)
		WD40 repeat	516..552	CDD:293791	18/37 (49%)
		WD40 repeat	558..613	CDD:293791	24/54 (44%)
		WD40 repeat	620..644	CDD:293791	14/23 (61%)
		Utp12	782..884	CDD:461125	37/102 (36%)