Protein Alignment CG12325 and pwp2

DIOPT Version :10

• Sequence 1: NP_610618.1
• Gene: CG12325 / 36144
• FlyBaseID: FBgn0033557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_595343.1
• Gene: pwp2 / 2541182
• PomBaseID: SPBC713.04C
• Length: 854
• Species: Schizosaccharomyces pombe
• Alignment Length: 906
• Identity: 364/906 - (40%)
• Similarity: 555/906 - (61%)
• Gaps: 71/906 - (7%)

  Fly     1 MKFSYKFSNLLGTIYRNGNLVFTPDGNSVISPVGNRITVYDLKNNKSRTLSLESRYNYTNIALSP 65
            ||..:.||||:|||:..|||||||||.|::||||||::||:||:|.|.|...|:..|.::|||||
pombe     1 MKTEFGFSNLVGTIFSKGNLVFTPDGFSILSPVGNRVSVYNLKDNTSYTFPFENHKNISHIALSP 65

  Fly    66 DGSLLIAVNEKGEAQLISMMSCTVIHRHKFQTGVQCICFSPNGAFFAVAVQNVVLIFCAPGEI-T 129
            ..:||::|:|:|...|.:.:..:|:|...|::.|..|.|||||.||||::..::.::..|..: .
pombe    66 TSTLLLSVDEEGRCILCNFLRRSVLHYFNFKSPVGAIEFSPNGKFFAVSLGKLIQVWRTPNSLEE 130

  Fly   130 GEYNPFVLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKIVAINYTKNFRTYNLSGHTDAIVA 194
            .|:.||||.|.:.|.|||:..:.||:|||......:|.:.::.:::..:.|....|:||.:.:|:
pombe   131 REFAPFVLHREYTGHFDDIVSISWSADSRFFISTSKDLTARLHSVDPIEGFHPCALTGHKNTVVS 195

  Fly   195 CFFEANSLHLNTISRNGQLCLWECSLAPSDLEDAERPKIAPPQRKKEKKAVSDNESEDDVENVVE 259
            .||..:...:.|:|::|.|.:|               |.:|..:..|   |.|.|:|
pombe   196 GFFSKDQQTIYTVSKDGALFVW---------------KYSPLFQAGE---VIDEEAE-------- 234

  Fly   260 KDALKEESTKEAEDVNHIKNEDETKSHPFFYKKITRHYLADEPRKEQRDVQLTAANYNTRTKVLV 324
                                |::|::|.:..|:  |||.       .::.:|..|.::..:.:||
pombe   235 --------------------ENKTRTHIWLIKE--RHYF-------NQNSKLRCAAFHPTSNLLV 270

  Fly   325 VAFSSGAFYLYELPDVNMIHSLSISDYPISAALFNCTGDWVALASREIGQLLVWEWQSEQYIMKQ 389
            |.||||.|.:||||...|::.|||:...|.....|.||||:|:.|.::|||||||||||.|::||
pombe   271 VGFSSGLFGIYELPSFTMLYQLSITQSNIDTLTVNSTGDWIAIGSSKLGQLLVWEWQSESYVLKQ 335

  Fly   390 QGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNKKFLVSSS 454
            |.|...::.:.||||||.|.||.:|.|:|:|:..|.||.|||::|||.|:|:.||:....|.|||
pombe   336 QSHYDALSTLQYSSDGQRIITGADDGKIKVWDMNSGFCIVTFTQHTSAVSGLCFSKRGNVLFSSS 400

  Fly   455 LDGTVRAFDVNRYRNFRTFTSPNPAQFSCVAVDYSGELVVAGGQDVFDIFLWSVKTGKLLEIISG 519
            |||:|||:|:.|||||||||:|:..||||:|||.|||:|.||.||.|:||:|||:||:|||.::|
pombe   401 LDGSVRAWDLIRYRNFRTFTAPSRVQFSCIAVDPSGEIVCAGSQDSFEIFMWSVQTGQLLETLAG 465

  Fly   520 HEGPVVSIAFSPVATSSTLVSGSWDKTVKIWNCLESNSEHETIDAVSDVTNVTFSPSGEEIAVAT 584
            |||||.|::|:  ::.|.|.||||||||:||:....:...|.:...|||.::.|.|.|:|:.||:
pombe   466 HEGPVSSLSFN--SSGSLLASGSWDKTVRIWDIFSRSGIVEPLPIPSDVLSLAFHPDGKEVCVAS 528

  Fly   585 LSGNITIFDIKSAGQVTTIEGRNDLSAGRLETDIITARKNAQANYFSTIEYSADGECILAAGKSA 649
            |.|.:|.::::...|.:.|:||.|||.||...|..||..::....|::|.|||||.|:|:||.|.
pombe   529 LDGQLTFWNVQEGKQTSLIDGRKDLSGGRRFDDARTAENSSLNKTFTSICYSADGSCVLSAGTSK 593

  Fly   650 NICIYHVREAILLKKFEITQNHSLDGLNDFISRKHLSEFGNMALVE---EREELEGGRVAIRLPG 711
            .:|:|.:...:|:|||::::|.||.|:.:.::.:.::|.|::.|::   |..:|| .|:...|||
pombe   594 YVCLYDIITGVLIKKFQLSKNESLQGVQEMLNSRKMTEAGSIELIDTQGEESDLE-DRIDRTLPG 657

  Fly   712 VQRGDMSSRRFQQEVRVFSVKFSPTGQAFAAAGTEGLCIYALDKGVVFDPFDLSLEVTPKAVHES 776
            .:|||:|:|:.:.|:....|:|||:|.|||||.||||.||:|....:|||.:|.:::||......
pombe   658 ARRGDLSARKTRPEIICHGVQFSPSGGAFAAATTEGLMIYSLYNDFLFDPINLDMDITPSTTLTM 722

  Fly   777 LKQQNYTKALVMSLKLNEPNLIALVLERVPYKDVELVCADLSPEFAQRLLQQLARQLQSTPHIEF 841
            ..:..:..:|||:|:|||..::..|.|.:|..|||.|..:|...:....:..|:.....||||||
pombe   723 CAEGEFLISLVMALRLNEYKVVQKVYESIPITDVEHVVQELPVSYLANFMGYLSSFAAETPHIEF 787

  Fly   842 YLQWSCCLLTKHG------NQDGVFQHTGLLALHEVLSRKYEMLNKICDYNKYTLKVLLDR 896
            :|:|...:||.||      |.:...|.|.|.....|||::   |:::...|::.|..|||:
pombe   788 HLRWMKSVLTYHGEYLRRKNFEFASQLTSLQKSIVVLSKR---LSQLSSNNEFQLSFLLDK 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12325	NP_610618.1	WD40	<20..424	CDD:441893	146/404 (36%)
		WD40 repeat	59..94	CDD:293791	13/34 (38%)
		WD40 repeat	99..143	CDD:293791	18/44 (41%)
		WD40 repeat	149..187	CDD:293791	8/37 (22%)
		WD40 repeat	192..247	CDD:293791	12/54 (22%)
		WD40	306..657	CDD:441893	174/350 (50%)
		WD40 repeat	353..391	CDD:293791	22/37 (59%)
		WD40 repeat	397..433	CDD:293791	19/35 (54%)
		WD40 repeat	438..474	CDD:293791	22/35 (63%)
		WD40 repeat	482..518	CDD:293791	24/35 (69%)
		WD40 repeat	524..557	CDD:293791	15/32 (47%)
		WD40 repeat	565..594	CDD:293791	12/28 (43%)
		Utp12	793..895	CDD:461125	34/107 (32%)
pwp2	NP_595343.1	WD40 repeat	19..54	CDD:293791	22/34 (65%)
		WD40	<20..176	CDD:441893	65/155 (42%)
		WD40 repeat	58..94	CDD:293791	13/35 (37%)
		WD40 repeat	99..144	CDD:293791	18/44 (41%)
		WD40	111..539	CDD:441893	194/484 (40%)
		WD40 repeat	150..188	CDD:293791	8/37 (22%)
		WD40 repeat	193..247	CDD:293791	18/99 (18%)
		WD40 repeat	258..293	CDD:293791	14/34 (41%)
		WD40 repeat	299..334	CDD:293791	20/34 (59%)
		WD40 repeat	342..378	CDD:293791	18/35 (51%)
		WD40	373..689	CDD:475233	149/318 (47%)
		WD40 repeat	384..408	CDD:293791	13/23 (57%)
		WD40 repeat	427..464	CDD:293791	25/36 (69%)
		WD40 repeat	470..496	CDD:293791	15/27 (56%)
		WD40 repeat	512..536	CDD:293791	10/23 (43%)
		Utp12	739..844	CDD:461125	34/107 (32%)