Protein Alignment CG12325 and F55F8.3

DIOPT Version :10

• Sequence 1: NP_610618.1
• Gene: CG12325 / 36144
• FlyBaseID: FBgn0033557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_491653.2
• Gene: F55F8.3 / 172224
• WormBaseID: WBGene00018891
• Length: 910
• Species: Caenorhabditis elegans
• Alignment Length: 957
• Identity: 343/957 - (35%)
• Similarity: 544/957 - (56%)
• Gaps: 62/957 - (6%)

  Fly     1 MKFSYKFSNLLGTIYRNGNLVFTPDGNSVISPVGNRITVYDLKNNKSRTLSLESRYNYTNIALSP 65
            |..::|.||.:||:||:|.:.|:.||.|||||:||:::::||:||.|:||.::..||...:::||
 Worm     1 MDTNFKLSNCIGTVYRDGQVAFSKDGYSVISPIGNKLSIFDLRNNTSKTLDIDCNYNIKRLSISP 65

  Fly    66 DGSLLIAVNEKGEAQLISMMSCTVIHRHKFQTGVQCICFSPNGAFFAVAVQNVVLIFCAPGEITG 130
            .|..|:|.:|:|....:.::|...|:..:....:..:.:||:....|:..:|.:.|......|..
 Worm    66 SGYHLLASDERGVVHFVHLLSEFKIYTFRSNKPIGSLQWSPDATRVAICRENDLQIHEFGKSIEN 130

  Fly   131 E-YNPFVLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKIVAINYTKNFRTYNLSGHTDAIVA 194
            : ||||.|.|.:....|.:..:|||.|:.||..|..|...::|.....||...:.|:.|...||.
 Worm   131 KVYNPFSLSRTYKLSSDSLKTIDWSDDANLLVSGGEDRVVRVVGAKDFKNLFIHPLASHKGYIVN 195

  Fly   195 CFFEANSLHLNTISRNGQLCLWECSLAPSDLEDAERPKIAPPQRKKEKKAVSDNESEDDVENVVE 259
            |.|..||..:.|:.:.|...:|.|:|.|.:|.:....|              |.|..||:|
 Worm   196 CQFMKNSYDMITVCKRGLANVWTCNLRPGELVEGIWKK--------------DEEGSDDIE---- 242

  Fly   260 KDALKEESTKEAEDVNHIKNEDETKSHPFFYKKITRHYLADEPRKEQRDVQLTAANYNTRTKVLV 324
                             :..:.|.|....|::| |:.|...|.....:.|.:|||.::..|.:|.
 Worm   243 -----------------MLEDGEQKVEKIFFEK-TKKYWLSESSGSGKSVDVTAARFHKETNILA 289

  Fly   325 VAFSSGAFYLYELPDVNMIHSLSISDYPISAALFNCTGDWVAL--ASREIGQLLVWEWQSEQYIM 387
            .||::|...|:|:|...::|:|.:|:..|....:|.||||:|:  ......||:|||||||.|:|
 Worm   290 TAFNNGVIVLHEIPSFALVHNLRVSEMRIQTVAWNLTGDWLAIGCGKGSTAQLVVWEWQSESYVM 354

  Fly   388 KQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNKKFLVS 452
            |||.||..:|...||.||..:|||.||.|||:||::||||.|||.|||||||.::::::.:.::|
 Worm   355 KQQAHSLRITTAEYSPDGSLMATGAEDGKVKIWNSRSSFCTVTFDEHTSGVTAVKWTQSGRAILS 419

  Fly   453 SSLDGTVRAFDVNRYRNFRTFTSPNPAQFSCVAVDYSGELVVAGGQDVFDIFLWSVKTGKLLEII 517
            :||||||||.|:.|||||||...|.|.|.:.:|||.:|:||:||.::||:|::||.:||.||:|:
 Worm   420 ASLDGTVRAHDLKRYRNFRTLVCPEPTQLATLAVDKAGDLVIAGAKEVFNIYIWSFETGHLLDIL 484

  Fly   518 SGHEGPVVSIAFSPVATSSTLVSGSWDKTVKIWNCLESNSEHETIDAVSDVTNVTFSPSGEEIAV 582
            ||||..:.||...    .:.:||||||:|:|:|..::|.:  ||::...:..:|.|||:|:||||
 Worm   485 SGHESAISSIDIH----GNHIVSGSWDRTIKMWTIVDSQA--ETVEVSHEALDVKFSPAGDEIAV 543

  Fly   583 ATLSGNITIFDIKSAGQVTTIEGRNDLSAGRLETDIITARKNAQANYFSTIEYSADGECILAAGK 647
            .|..|.||.|:.|....:.:|:.:.|....|...|.||.:..|:...|:.|.:|.||..:||.|:
 Worm   544 LTSDGVITFFEAKEMINLGSIDTKLDTDPARGSRDTITRQSAAKTKTFTRIRFSPDGNLLLAGGE 608

  Fly   648 SANICIYHVREAILLKKFEITQNHSLDGLNDFISRKHLSEFGNMALV---EEREELE-GGRVAIR 708
            |.|.|:|.|.|.::|||::||.|.||||:....:|::.:|||||.||   :|.:||| ..:::|:
 Worm   609 SNNFCLYSVPERMILKKWQITANRSLDGVILDFNRRNFTEFGNMQLVDTSDEEDELEPNNKMSIK 673

  Fly   709 LPGVQRGDMSSRRFQQEVRVFSVKFSPTGQAFAAAGTEGLCIYALDKGVVFDPFDLSLEVTPKAV 773
            |||.:..|:..||.:.||.::.|.:.|||:.||...|||:.:|:||...:||||.|..:...:.:
 Worm   674 LPGTKNFDLGERRARPEVNIYEVTYCPTGRRFAICSTEGVSVYSLDTISMFDPFQLDSQTNAEVI 738

  Fly   774 HESLKQQNYTKALVMSLKLNEPNLIALVLERVPYKDVELVCADLSPEFAQRLLQQL--ARQLQST 836
            ..::...:|:.|::.||:||....|...||......:.||.:.|...:|:|||:.:  ...:.||
 Worm   739 KRAVWNNDYSTAIMASLRLNNAQYITECLESTSISQIPLVASSLPLMYAERLLKWMVEGNVMSST 803

  Fly   837 PHIEFYLQWSCCLLTKHGNQ-DGVFQHTGLLALHEVLSRKYEMLNKICDYNKYTLK--VLLDRAD 898
            .|:.||:.|...:|..||.| .|......|..:.::::...:.:.|:.:.||:.|.  |.:.::.
 Worm   804 RHVHFYMIWLRAILQHHGMQLKGRADVATLTGIQQIVAHHQQHITKLANQNKFALNWLVKIRQSK 868

  Fly   899 KLEQKNEGKPNATEEDSDEEMLLIRSKDDENGQAQFSDEEESDSGSE 945
            |..:|.|.:.....::||:|.:    :|:..|    ||:|:||...|
 Worm   869 KSVKKEEEEEEDVSDESDDEDI----EDESAG----SDDEDSDDSVE 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12325	NP_610618.1	WD40	<20..424	CDD:441893	133/406 (33%)
		WD40 repeat	59..94	CDD:293791	9/34 (26%)
		WD40 repeat	99..143	CDD:293791	12/44 (27%)
		WD40 repeat	149..187	CDD:293791	12/37 (32%)
		WD40 repeat	192..247	CDD:293791	14/54 (26%)
		WD40	306..657	CDD:441893	157/352 (45%)
		WD40 repeat	353..391	CDD:293791	20/39 (51%)
		WD40 repeat	397..433	CDD:293791	22/35 (63%)
		WD40 repeat	438..474	CDD:293791	19/35 (54%)
		WD40 repeat	482..518	CDD:293791	18/35 (51%)
		WD40 repeat	524..557	CDD:293791	12/32 (38%)
		WD40 repeat	565..594	CDD:293791	14/28 (50%)
		Utp12	793..895	CDD:461125	28/106 (26%)
F55F8.3	NP_491653.2	WD40	58..388	CDD:475233	112/365 (31%)
		WD40 repeat	58..94	CDD:293791	9/35 (26%)
		WD40 repeat	99..144	CDD:293791	12/44 (27%)
		WD40 repeat	150..188	CDD:293791	12/37 (32%)
		WD40 repeat	193..256	CDD:293791	21/97 (22%)
		WD40	<276..550	CDD:441893	133/279 (48%)
		WD40 repeat	277..312	CDD:293791	12/34 (35%)
		WD40 repeat	318..358	CDD:293791	20/39 (51%)
		WD40 repeat	364..400	CDD:293791	22/35 (63%)
		WD40 repeat	405..441	CDD:293791	19/35 (54%)
		WD40 repeat	449..485	CDD:293791	18/35 (51%)
		WD40 repeat	491..524	CDD:293791	14/38 (37%)
		WD40 repeat	530..584	CDD:293791	21/53 (40%)
		WD40 repeat	591..613	CDD:293791	10/21 (48%)
		Utp12	759..861	CDD:461125	26/101 (26%)