Protein Alignment CG12325 and LOC102724159

DIOPT Version :10

• Sequence 1: NP_610618.1
• Gene: CG12325 / 36144
• FlyBaseID: FBgn0033557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_001355167.1
• Gene: LOC102724159 / 102724159
• -ID: -
• Length: 919
• Species: Homo sapiens
• Alignment Length: 955
• Identity: 444/955 - (46%)
• Similarity: 625/955 - (65%)
• Gaps: 56/955 - (5%)

  Fly     1 MKFSYKFSNLLGTIYRNGNLVFTPDGNSVISPVGNRITVYDLKNNKSRTLSLESRYNYTNIALSP 65
            |||:|:|||||||:||.|||.||.:|||||||||||:||:|||||||.||.|.:|||...:.|||
Human     1 MKFAYRFSNLLGTVYRRGNLNFTCNGNSVISPVGNRVTVFDLKNNKSDTLPLATRYNVKCVGLSP 65

  Fly    66 DGSLLIAVNEKGEAQLISMMSCTVIHRHKFQTGVQCICFSPNGAFFAVAVQNVVLIFCAPGEITG 130
            ||.|.|.|:|.|:|.|:|::..:|:|...|:..|..:.|||:|..|.|...|:..::.|||: ..
Human    66 DGRLAIIVDEGGDALLVSLVCRSVLHHFHFKGSVHSVSFSPDGRKFVVTKGNIAQMYHAPGK-KR 129

  Fly   131 EYNPFVLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKIVAINYTKNFRTYNLSGHTDAIVAC 195
            |:|.|||.:.:.|.:|:.|.:||:.|||...:|.:|.||.:.......|...|.|.||.||||||
Human   130 EFNAFVLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVAC 194

  Fly   196 FFEANSLHLNTISRNGQLCLWECSLAPSDLEDAERPKIAPP--------QRKKEKKAVSDNESED 252
            |||:|||.|.::|::|.||:|:|...|..|      ::.||        ||::|:      |.|:
Human   195 FFESNSLDLYSLSQDGVLCMWQCDTPPEGL------RLKPPAGWKADLLQREEEE------EEEE 247

  Fly   253 DVENVVEKDALKEESTKEAEDVNHIKNEDETKSHPFFYKKITRHYLADEPRKEQRDVQLTAANYN 317
            |.|...|.....:.:..|.|....:|           |.::.:::.    .||.....||||.::
Human   248 DQEGDRETTIRGKATPAEEEKTGKVK-----------YSRLAKYFF----NKEGDFNNLTAAAFH 297

  Fly   318 TRTKVLVVAFSSGAFYLYELPDVNMIHSLSISDYPISAALFNCTGDWVALASREIGQLLVWEWQS 382
            .::.:||..|:||.|:|:|||:.|:||||||||..|::...|.:|||:|.....:||||||||||
Human   298 KKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEWQS 362

  Fly   383 EQYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNK 447
            |.|::|||||.:.|..:|||.|||:|.|||:|.|||:|||.|.||||||:||:|||||:.|:...
Human   363 ESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATG 427

  Fly   448 KFLVSSSLDGTVRAFDVNRYRNFRTFTSPNPAQFSCVAVDYSGELVVAGGQDVFDIFLWSVKTGK 512
            ..:|:||:||||||||::|||||||||||.|.||||||||.|||:|.||.||.|:||:||::||:
Human   428 YVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGR 492

  Fly   513 LLEIISGHEGPVVSIAFSPVATSSTLVSGSWDKTVKIWNCLESNSEHETIDAVSDVTNVTFSPSG 577
            ||:::||||||:..:.|:|:  .|.|.|.||||||::|:..:|....||:...||...|||.|.|
Human   493 LLDVLSGHEGPISGLCFNPM--KSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDG 555

  Fly   578 EEIAVATLSGNITIFDIKSAGQVTTIEGRNDLSAGRLETDIITARKNAQANYFSTIEYSADGECI 642
            .|:|||||:..||.:|.::|.|..:||||:||..||.|.|.|||:..|:...|:.:.|||||..|
Human   556 AELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHSI 620

  Fly   643 LAAGKSANICIYHVREAILLKKFEITQNHSLDGLNDFISRKHLSEFGNMALVEEREELEGGRVAI 707
            ||.|.|..:|||||||.||:|:|||:.|.|||.:.:|::|:.::||||:||:::....|.| |||
Human   621 LAGGMSKFVCIYHVREQILMKRFEISCNLSLDAMEEFLNRRKMTEFGNLALIDQDAGQEDG-VAI 684

  Fly   708 RLPGVQRGDMSSRRFQQEVRVFSVKFSPTGQAFAAAGTEGLCIYALDKGVVFDPFDLSLEVTPKA 772
            .||||::||||||.|:.|:||.|::|||||:.:||..||||.||:||..|:||||:|...|||..
Human   685 PLPGVRKGDMSSRHFKPEIRVTSLRFSPTGRCWAATTTEGLLIYSLDTRVLFDPFELDTSVTPGR 749

  Fly   773 VHESLKQQNYTKALVMSLKLNEPNLIALVLERVPYKDVELVCADLSPEFAQRLLQQLARQLQSTP 837
            |.|:|:||::|:|::|:|:|||..|:...||.||..::|:|.:.|...:.:::|:.||...:.:.
Human   750 VREALRQQDFTRAILMALRLNESKLVQEALEAVPRGEIEVVTSSLPELYVEKVLEFLASSFEVSR 814

  Fly   838 HIEFYLQWSCCLLTKHGNQDGVFQHTGLLA-----LHEVLSRKYEMLNKICDYNKYTLKVLLDRA 897
            |:||||.|:..||..||.:  :....|.|.     |.:.:.|..:.|:|:|.:|.|.::..|..:
Human   815 HLEFYLLWTHKLLMLHGQK--LKSRAGTLLPVIQFLQKSIQRHLDDLSKLCSWNHYNMQYALAVS 877

  Fly   898 DKLEQKNEGKPNATEEDSDEEMLLIRSKDDE----NGQAQFSDEE 938
            .:...|....|..:||:::      .|:||.    .|..:.|:||
Human   878 KQRGTKRSLDPLGSEEEAE------ASEDDSLHLLGGGGRDSEEE 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12325	NP_610618.1	WD40	<20..424	CDD:441893	179/411 (44%)
		WD40 repeat	59..94	CDD:293791	15/34 (44%)
		WD40 repeat	99..143	CDD:293791	16/43 (37%)
		WD40 repeat	149..187	CDD:293791	13/37 (35%)
		WD40 repeat	192..247	CDD:293791	24/62 (39%)
		WD40	306..657	CDD:441893	195/350 (56%)
		WD40 repeat	353..391	CDD:293791	20/37 (54%)
		WD40 repeat	397..433	CDD:293791	24/35 (69%)
		WD40 repeat	438..474	CDD:293791	22/35 (63%)
		WD40 repeat	482..518	CDD:293791	23/35 (66%)
		WD40 repeat	524..557	CDD:293791	13/32 (41%)
		WD40 repeat	565..594	CDD:293791	15/28 (54%)
		Utp12	793..895	CDD:461125	32/106 (30%)
LOC102724159	NP_001355167.1	YncE	<29..>114	CDD:442618	45/84 (54%)
		WD40	96..443	CDD:475233	158/374 (42%)
		WD40 repeat	101..142	CDD:293791	15/41 (37%)
		WD40 repeat	148..186	CDD:293791	13/37 (35%)
		WD40 repeat	191..258	CDD:293791	29/78 (37%)
		WD40	291..635	CDD:441893	195/345 (57%)
		WD40 repeat	292..327	CDD:293791	17/34 (50%)
		WD40 repeat	333..371	CDD:293791	20/37 (54%)
		WD40 repeat	377..413	CDD:293791	24/35 (69%)
		WD40 repeat	418..454	CDD:293791	22/35 (63%)
		WD40 repeat	462..498	CDD:293791	23/35 (66%)
		WD40 repeat	504..541	CDD:293791	15/38 (39%)
		WD40 repeat	546..601	CDD:293791	29/54 (54%)
		WD40 repeat	608..632	CDD:293791	12/23 (52%)
		Utp12	770..875	CDD:461125	32/106 (30%)