Protein Alignment CG12325 and pwp2

DIOPT Version :10

• Sequence 1: NP_610618.1
• Gene: CG12325 / 36144
• FlyBaseID: FBgn0033557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: XP_031751571.1
• Gene: pwp2 / 100158563
• XenbaseID: XB-GENE-6257709
• Length: 893
• Species: Xenopus tropicalis
• Alignment Length: 949
• Identity: 430/949 - (45%)
• Similarity: 608/949 - (64%)
• Gaps: 63/949 - (6%)

  Fly     1 MKFSYKFSNLLGTIYRNGNLVFTPDGNSVISPVGNRITVYDLKNNKSRTLSLESRYNYTNIALSP 65
            ||:||||||||||.||.|||.|||||||:|||||||::::.||||...||.|.:|.|.|.:||||
 Frog     1 MKYSYKFSNLLGTFYRRGNLSFTPDGNSLISPVGNRLSIFHLKNNNGETLPLATRCNITCVALSP 65

  Fly    66 DGSLLIAVNEKGEAQLISMMSCTVIHRHKFQTGVQCICFSPNGAFFAVAVQNVVLIFCAPGEITG 130
            ||||.|.|:|:|.|.|||..:.:|:::..||..||.:.|||:|..|.:...||.:::.|||: ..
 Frog    66 DGSLGILVDEEGAALLISFATKSVLNQFSFQQPVQSVSFSPDGRKFLLTKGNVAMLYHAPGK-RR 129

  Fly   131 EYNPFVLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKIVAINYTKNFRTYNLSGHTDAIVAC 195
            |:|.|||.:.|.|.:|:.|.:||:.||:..|:|.:|.||.:......:|...|:|.||.||||||
 Frog   130 EFNAFVLDKTFYGPYDETTCIDWTDDSKCFAVGSKDMSTWVFGAERWQNLIYYSLGGHKDAIVAC 194

  Fly   196 FFEANSLHLNTISRNGQLCLWECSLAPSDLEDAERPKIAPPQRKKEKKAVSDNESEDDVENVVEK 260
            ||:..||.|.|||.:..||:|.|        |.|..::.|  |..:|||.....:|:.....:..
 Frog   195 FFQEGSLDLYTISADATLCVWGC--------DTELAQLLP--RDPDKKARESGGAEEPRAEEIRG 249

  Fly   261 DALKEESTKEAEDVNHIKNEDETKSHPFFYKKITRHYLADEPRKEQRDVQLTAANYNTRTKVLVV 325
            .|    :....|.|..::           |:|.:||:.    .||.....||||.::.:..:||.
 Frog   250 TA----NPAPEESVGRVR-----------YRKSSRHFF----NKEGDFTALTAAAFHKKLNILVT 295

  Fly   326 AFSSGAFYLYELPDVNMIHSLSISDYPISAALFNCTGDWVALASREIGQLLVWEWQSEQYIMKQQ 390
            .||||.|:::|||::::||||||||..:|....||||||:|.....:|||||||||||.|::|||
 Frog   296 GFSSGMFHIHELPELSLIHSLSISDQRVSTISINCTGDWIAFGCSGLGQLLVWEWQSESYVLKQQ 360

  Fly   391 GHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNKKFLVSSSL 455
            ||.:.|..::||.|||.|.|||:|.|||:|:|.|.||||||::|||.||.:.|:.:.:.::|:||
 Frog   361 GHFNNMGALSYSPDGQHIVTGGDDGKVKVWDTSSGFCFVTFTDHTSSVTAVTFASSGQVILSASL 425

  Fly   456 DGTVRAFDVNRYRNFRTFTSPNPAQFSCVAVDYSGELVVAGGQDVFDIFLWSVKTGKLLEIISGH 520
            |||||||.:.|||||||||||.||||||:|||.|||:|.||.||.:::::||::||:||:::|||
 Frog   426 DGTVRAFSLLRYRNFRTFTSPKPAQFSCLAVDGSGEIVCAGAQDSYEVYVWSMQTGRLLDVLSGH 490

  Fly   521 EGPVVSIAFSPVATSSTLVSGSWDKTVKIWNCLESNSEHETIDAVSDVTNVTFSPSGEEIAVATL 585
            |||:..:||:|  ..|.|.:.||||||::|:.::|....||::..||...|||.|.|.|||||::
 Frog   491 EGPISCVAFNP--WRSVLATASWDKTVRLWDMVDSWRTTETLNLTSDALAVTFRPDGREIAVASM 553

  Fly   586 SGNITIFDIKSAGQVTTIEGRNDLSAGRLETDIITARKNAQANYFSTIEYSADGECILAAGKSAN 650
            .|.||.::.:...|..:||||:||..||.|.|.:||:.:::...|:.:.|:|||:.:||.|.|..
 Frog   554 DGQITFWESEKGTQTGSIEGRHDLKLGRKELDKVTAKHSSKGKAFTALCYTADGQALLAGGASRY 618

  Fly   651 ICIYHVREAILLKKFEITQNHSLDGLNDFISRKHLSEFGNMALVEEREELEGGRVAIRLPGVQRG 715
            :|:|||.|.||.|||||:.|||||.:.:|:.|:.::|||::||::|....||| |::.||||.||
 Frog   619 VCLYHVGEQILAKKFEISCNHSLDAMEEFLDRRKMTEFGSVALIDEGTGEEGG-VSLSLPGVHRG 682

  Fly   716 DMSSRRFQQEVRVFSVKFSPTGQAFAAAGTEGLCIYALDKGVVFDPFDLSLEVTPKAVHESLKQQ 780
            |||||.|:.|:||.|:.|||||:::||..||||.|::||...|||||||..|||...|..:|:..
 Frog   683 DMSSRHFKPEIRVSSLHFSPTGRSWAATSTEGLLIFSLDSSAVFDPFDLDEEVTAGGVRRALRGA 747

  Fly   781 NYTKALVMSLKLNEPNLIALVLERVPYKDVELVCADLSPEFAQRLLQQLARQLQSTPHIEFYLQW 845
            .:|:|:||:::|||.:|:...||.||..|:.::|:.|...:.||||..||.|::.:.|::|||.|
 Frog   748 EWTRAIVMAMRLNEESLLREALESVPCADIAVLCSSLPELYVQRLLVFLATQIERSRHLQFYLMW 812

  Fly   846 SCCLLTKHGNQDGVFQHTGLLALHEV---LSRKYEMLNKICDYNKYTLKVLLDRADKLEQKNEGK 907
            :..||..||:.......:.|.|:|.:   |......::|:|::|:|.:|..|     ...:..|.
 Frog   813 AHQLLLLHGHSMKSRSVSVLPAVHSLQKSLQGHLSEISKLCEWNRYNMKFAL-----CLSRQRGM 872

  Fly   908 PNATEEDSDEEMLLIRSKDDENGQAQFSDEEESDSGSEE 946
            ....||                      .|.||.|||.|
 Frog   873 KRGAEE----------------------SEAESVSGSLE 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12325	NP_610618.1	WD40	<20..424	CDD:441893	177/403 (44%)
		WD40 repeat	59..94	CDD:293791	18/34 (53%)
		WD40 repeat	99..143	CDD:293791	18/43 (42%)
		WD40 repeat	149..187	CDD:293791	13/37 (35%)
		WD40 repeat	192..247	CDD:293791	23/54 (43%)
		WD40	306..657	CDD:441893	181/350 (52%)
		WD40 repeat	353..391	CDD:293791	22/37 (59%)
		WD40 repeat	397..433	CDD:293791	22/35 (63%)
		WD40 repeat	438..474	CDD:293791	20/35 (57%)
		WD40 repeat	482..518	CDD:293791	19/35 (54%)
		WD40 repeat	524..557	CDD:293791	13/32 (41%)
		WD40 repeat	565..594	CDD:293791	15/28 (54%)
		Utp12	793..895	CDD:461125	35/104 (34%)
pwp2	XP_031751571.1	WD40	10..394	CDD:441893	185/413 (45%)
		WD40 repeat	19..52	CDD:293791	22/32 (69%)
		WD40 repeat	59..94	CDD:293791	18/34 (53%)
		WD40 repeat	99..136	CDD:293791	15/37 (41%)
		WD40 repeat	148..186	CDD:293791	13/37 (35%)
		WD40 repeat	191..272	CDD:293791	31/105 (30%)
		WD40	275..634	CDD:441893	188/360 (52%)
		WD40 repeat	281..318	CDD:293791	18/36 (50%)
		WD40 repeat	323..361	CDD:293791	22/37 (59%)
		WD40 repeat	367..403	CDD:293791	22/35 (63%)
		WD40 repeat	408..444	CDD:293791	20/35 (57%)
		WD40 repeat	452..488	CDD:293791	19/35 (54%)
		WD40 repeat	494..531	CDD:293791	15/38 (39%)
		WD40 repeat	536..575	CDD:293791	17/38 (45%)
		Utp12	760..864	CDD:461125	35/103 (34%)