DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dgo and ANKRD30A

DIOPT Version :9

Sequence 1:	NP_610614.1	Gene:	dgo / 36139	FlyBaseID:	FBgn0086898	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_011518059.1	Gene:	ANKRD30A / 91074	HGNCID:	17234	Length:	1585	Species:	Homo sapiens

Alignment Length:	996	Identity:	204/996 - (20%)
Similarity:	321/996 - (32%)	Gaps:	293/996 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSSNWTSLHEAVAAGDDRRVEGLLFSNADRLARESVQGNTPLHEAA-SRGFSRCVKLICTPPTPP 85
            |..:.|.|.:|:....:.....|:.|.|| :....|.|||.||.|. |...|...||:
Human   103 DGEHRTPLMKALQCHQEACANILIDSGAD-INLVDVYGNTALHYAVYSEILSVVAKLL------- 159

  Fly    86 ASSGVGKAAKGQKDKDKDKNKGRVKVAHQTIEALHNSALGIANNEGLSALHLAAQNGHNQSSREL 150
                                      :|..:..:||.|       .|:.|.|:......|....|
Human   160 --------------------------SHGAVIEVHNKA-------SLTPLLLSITKRSEQIVEFL 191

  Fly   151 LLAGADPDVRNNYGDTPLHTACRYGHAGVSRILLSALCDPNKTNLNGDTALHITCAMGRRKLTRI 215
            |:..|:.:..|.|..|.|..|..:|.:.:..:||....|....::.|.||.|.....|...:...
Human   192 LIKNANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGFHHIHEQ 256

  Fly   216 LLEADARLGIKNAQGDCP---------------------MHIAIRKNYREIIEIL-NTPKKIRNR 258
            ::|...:|. ||.|...|                     ....:.|...|...:: .||....:.
Human   257 IMEYIRKLS-KNHQNTNPEGTSAGTPDEAAPLAERTPDTAESLVEKTPDEAAPLVERTPDTAESL 320

  Fly   259 KEK-PKEGGS----RSDK-----------------DRDRE-----RDVVDKGINWSPYGCHYFPD 296
            .|| |.|..|    .|||                 :..||     ::..:| ..|...|     .
Human   321 VEKTPDEAASLVEGTSDKIQCLEKATSGKFEQSAEETPREITSPAKETSEK-FTWPAKG-----R 379

  Fly   297 PRAFPSPKLETLPKE---PLKSGEQYFL--------DLAGHIHKGPVSVGNTCYCGPFFRHIENK 350
            ||.....|.|..|:|   |.|...:.|.        .:|....:.||..|  |..    |...||
Human   380 PRKIAWEKKEDTPREIMSPAKETSEKFTWAAKGRPRKIAWEKKETPVKTG--CVA----RVTSNK 438

  Fly   351 LNCNRKSLKKYVH-KTKERLGHKVQALAIKTNDQIEQLTRTMIEDRLRCESKRQHLSEFLRRGEP 414
            .....|...|.:. .|||      .:.....|||           |...|||::...|:   ...
Human   439 TKVLEKGRSKMIACPTKE------SSTKASANDQ-----------RFPSESKQEEDEEY---SCD 483

  Fly   415 MRSTFDQQNKSSRIERTMSRCRSLELLENNHE-------------GGRLTNS---RSVDVLEDQA 463
            .||.|:   .|::|:..:......:::|.|.|             ...:.||   ::.::..:|.
Human   484 SRSLFE---SSAKIQVCIPESIYQKVMEINREVEEPPKKPSAFKPAIEMQNSVPNKAFELKNEQT 545

  Fly   464 VEAIVHRSAEVQVDSDSDDDSNEARDEEE--AEVGDKDQVQEEAEPEE-----HSKLDEL--KLD 519
            :.|    ......:|...|....:.|.|.  ..|..||....:|..::     :.||:|.  |..
Human   546 LRA----DPMFPPESKQKDYEENSWDSESLCETVSQKDVCLPKATHQKEIDKINGKLEESPNKDG 606

  Fly   520 FLKVSERLGVLLEKTTLIMERDSEQESKRQLSSLSPPYNP---HPRAESAQLREDK--ESVNSPN 579
            .||.:  .|:.:...|..:|....|..|.:     ||..|   .|..|..:...:|  |..|...
Human   607 LLKAT--CGMKVSIPTKALELKDMQTFKAE-----PPGKPSAFEPATEMQKSVPNKALELKNEQT 664

  Fly   580 F--DEYANVIRRYPNSSETSNPSQNSNSWDWEA-SPTGSN-----PHPDYNKYYQRI-GRGE--- 632
            .  ||..        .||:.......||||.|: ..|.|.     |...:.|...:| |:.|
Human   665 LRADEIL--------PSESKQKDYEENSWDTESLCETVSQKDVCLPKAAHQKEIDKINGKLEGRY 721

  Fly   633 ----NMLNSVIKALRKDASF-ADLGKEETAVNETAEGMGGDKLLYKEQASEAAGISNLMKRQPLC 692
                ...:::|::..||... |:.|.:.:...:..|.|  |...:|.:..|          :|..
Human   722 AAEFRTFSAMIRSPVKDGLLKANCGMKVSIPTKALELM--DMQTFKAEPPE----------KPSA 774

  Fly   693 LEDNYPVMSNLFYSNPIMEYAEETEVRQNGNESMSKVEIRNSEIKCLKKPNAGQVRDMVAQLQNT 757
            .|....:..::  .|..:|...|..:|.:        ||..||.|                 |..
Human   775 FEPAIEMQKSV--PNKALELKNEQTLRAD--------EILPSESK-----------------QKD 812

  Fly   758 IDSNRQDSQT---------------AHVIAARSHSRLNNNFHHLEGTSSNPSPTYSIPHRSSAQF 807
            .:.:..||::               ||   .:...::|..   |||..:....|:|...||..:.
Human   813 YEESSWDSESLCETVSQKDVCLPKAAH---QKEIDKINGK---LEGRYAAEFRTFSAMIRSPVKD 871

  Fly   808 GLPERH------IPKDAY-------FHELPHRPPIPQTPQRRLHSGYVPNASL-------YRSED 852
            ||.:.:      ||..|.       |...|...|....|...:... |||.:|       .|:::
Human   872 GLLKANCGMKVSIPTKALELMDMQTFKAEPPEKPSAFEPAIEMQKS-VPNKALELKNEQTLRADE 935

  Fly   853 LYVGRIPHPNAPPRQVDYVDA 873
            :    :|   :..:|.||.::
Human   936 I----LP---SESKQKDYEES 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgo	NP_610614.1	ANK	22..184	CDD:238125	36/162 (22%)
		ANK repeat	24..55	CDD:293786	7/30 (23%)
		Ank_2	29..161	CDD:289560	28/132 (21%)
		ANK repeat	59..128	CDD:293786	14/69 (20%)
		ANK	126..249	CDD:238125	29/143 (20%)
		ANK repeat	130..161	CDD:293786	7/30 (23%)
		Ank_2	135..227	CDD:289560	22/91 (24%)
		ANK repeat	163..194	CDD:293786	8/30 (27%)
		ANK repeat	196..227	CDD:293786	7/30 (23%)
ANKRD30A	XP_011518059.1	Ank_4	42..93	CDD:290365
		ANK repeat	42..70	CDD:293786
		ANK	67..192	CDD:238125	27/129 (21%)
		ANK repeat	74..103	CDD:293786	204/996 (20%)
		Ank_2	77..169	CDD:289560	20/99 (20%)
		ANK repeat	105..136	CDD:293786	7/31 (23%)
		ANK	133..253	CDD:238125	36/159 (23%)
		ANK repeat	138..169	CDD:293786	11/63 (17%)
		Ank_2	143..235	CDD:289560	27/131 (21%)
		ANK repeat	171..202	CDD:293786	8/37 (22%)
		ANK repeat	204..235	CDD:293786	8/30 (27%)
		Ank_2	209..>278	CDD:289560	17/69 (25%)
		ANK repeat	237..270	CDD:293786	9/33 (27%)
		CCDC144C	1251..1540	CDD:291576
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I5159
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050