DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dgo and ANKRD20A1

DIOPT Version :9

Sequence 1:	NP_610614.1	Gene:	dgo / 36139	FlyBaseID:	FBgn0086898	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_115626.2	Gene:	ANKRD20A1 / 84210	HGNCID:	23665	Length:	823	Species:	Homo sapiens

Alignment Length:	849	Identity:	171/849 - (20%)
Similarity:	286/849 - (33%)	Gaps:	247/849 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SNWTSLHEAVAAGDDRRVEGLLFSNADRLARESVQGNTPLHEAASRGFSRCVKLICTPPTPPASS 88
            |....:|.|...||...||..|...:..|.....|..|.||.|.:.|..:.|.|:..
Human    32 SELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACTSGHVQVVTLLVN-------- 88

  Fly    89 GVGKAAKGQKDKDKDKNKGRVKVAHQTIEALHNSALGIANNEGLSALHLAAQNGHNQSSRELLLA 153
                 .|.|.|....:|:..:      |:|:|      ...|..:.:              ||..
Human    89 -----RKCQIDVCDKENRTPL------IQAVH------CQEEACAVI--------------LLEH 122

  Fly   154 GADPDVRNNYGDTPLHTACRYGHAGVSRILLS------ALCDPNKTNLNGDTALHITCAMGRRKL 212
            ||:|::::.||:|.||.|.......::..|||      ||...|.|.|    ...|.|.  :.|:
Human   123 GANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPL----LFAIICK--KEKM 181

  Fly   213 TRILLEADA------RL--------------GIKN----------AQGDC---PMHIAIRKNYRE 244
            ...||:..|      ||              ||.|          ||..|   ....||..:..:
Human   182 VEFLLKKKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTK 246

  Fly   245 I-IEILNTPKKIRNRKEKPKEGGS-----------------RSDKDRDRERDVVDKGINWSPYGC 291
            | .:||...|||. :|||...|.|                 .||          ||.:|.:...|
Human   247 IQQQILEHKKKIL-KKEKSDVGSSDESAVSIFHELRVDSLPASD----------DKDLNVATKQC 300

  Fly   292 HYFPDPRAFPSPKLETLPKEPLKSGEQYFLDLAGHIHKGPVSVGNTCYCGPFFRH--IENKLNCN 354
                    .|....|.||               |..|:....:.|....||..:|  ::......
Human   301 --------VPEKVSEPLP---------------GSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVE 342

  Fly   355 RKSLKKYVHKTKERLGHKVQALAIKTNDQIEQLTRTMIEDRLRCESKRQHLSEFLRRGEPMRSTF 419
            ..::|..|.:...:.....|||.:.:.:                |.:|...||   :.:|.....
Human   343 DPAVKGAVQRKNVQTLRAEQALPVASEE----------------EQERHERSE---KKQPQVKEG 388

  Fly   420 DQQNKSSRIERTMSRCRSLELLENNHEGGRLTNSRSVDVLEDQAVEAIVHRSAEVQVDSDSDDDS 484
            :..|||.:|:.:.:.|.|    .::...||||..|.:.....|....        ::..:.|..:
Human   389 NNTNKSEKIQLSENICDS----TSSAAAGRLTQQRKIGKTYPQQFPK--------KLKEEHDRCT 441

  Fly   485 NEARDEEEAEVG---DKDQVQEEAEPEEHSKLDELKLDFLKVSERLGVLLEKTTLIMERDSEQES 546
            .:..:||:..|.   .|::.:.|.:.:::.|..|.|            .||.|.    :..|.:|
Human   442 LKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAK------------QLEPTV----QSLEMKS 490

  Fly   547 KRQLSSLSPPYNPHP------------RAESAQLREDKESVNSPNFDEYANVIRRYPNSSETSNP 599
            |...::.:..::.|.            :|:.|.||::..::.:.|.::....::......||:..
Human   491 KTARNTPNWDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAA 555

  Fly   600 SQNSNSWDWEASPTGSNPHPDYNKYYQRIGRGENMLNSVIKALRKDASFADLGKEETAVN----- 659
            .:                     ||   |...|.|:...  |.|......||..|.|.:|
Human   556 LE---------------------KY---IKLNEEMITET--AFRYQQELNDLKAENTRLNAELLK 594

  Fly   660 --ETAEGMGGDKLLYKEQASEAAGIS------NLMKRQPLCLEDNYPVMSNLFYSNPIMEYAEET 716
              |:.:.:..|...|  |:..||.||      ...:...|.||....|...:..|:.|.:...|.
Human   595 EKESKKRLEADIESY--QSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKAEN 657

  Fly   717 EVRQNGNESMSKVEIRNSEIKCLKKPNAGQVRD---MVAQLQNTIDSNRQDSQTAHVIAARSHSR 778
            |..   .|.:|:.:|:.:.:|...:.....:|.   .:..:||.:...:|.:|....:...:.::
Human   658 EFL---TEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAK 719

  Fly   779 LNNN 782
            :||:
Human   720 VNNS 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgo	NP_610614.1	ANK	22..184	CDD:238125	36/159 (23%)
		ANK repeat	24..55	CDD:293786	9/30 (30%)
		Ank_2	29..161	CDD:289560	29/131 (22%)
		ANK repeat	59..128	CDD:293786	14/68 (21%)
		ANK	126..249	CDD:238125	37/162 (23%)
		ANK repeat	130..161	CDD:293786	6/30 (20%)
		Ank_2	135..227	CDD:289560	29/117 (25%)
		ANK repeat	163..194	CDD:293786	12/36 (33%)
		ANK repeat	196..227	CDD:293786	10/50 (20%)
ANKRD20A1	NP_115626.2	ANK repeat	37..64	CDD:293786	8/26 (31%)
		ANK	61..186	CDD:238125	38/169 (22%)
		ANK 1	66..95		10/41 (24%)
		ANK repeat	68..97	CDD:293786	10/41 (24%)
		ANK repeat	99..130	CDD:293786	10/56 (18%)
		ANK 2	99..128		10/54 (19%)
		ANK	127..247	CDD:238125	30/125 (24%)
		ANK repeat	132..163	CDD:293786	10/30 (33%)
		ANK 3	132..161		9/28 (32%)
		ANK repeat	165..196	CDD:293786	9/36 (25%)
		ANK 4	165..194		9/34 (26%)
		ANK repeat	198..229	CDD:293786	5/30 (17%)
		ANK 5	198..227		4/28 (14%)
		Mitofilin	291..690	CDD:313027	91/499 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..343		10/56 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..402		12/65 (18%)
		CCDC144C	514..805	CDD:317340	46/241 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I5159
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050