DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dgo and ANKRD36B

DIOPT Version :9

Sequence 1:	NP_610614.1	Gene:	dgo / 36139	FlyBaseID:	FBgn0086898	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001380868.1	Gene:	ANKRD36B / 57730	HGNCID:	29333	Length:	1353	Species:	Homo sapiens

Alignment Length:	866	Identity:	157/866 - (18%)
Similarity:	288/866 - (33%)	Gaps:	280/866 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LHEAVAAGDDRRVEGLLFSNADRLARESVQGNTPLHEAASRGFSRCVKLICTPPTPPASSGVGKA 93
            :|.||..|:..:::.||.:..|...|:..: .|.||.|.:.|....|.|:.:
Human    24 IHRAVLRGNLEKLKYLLLTYYDANKRDRKE-RTALHLACATGQPEMVHLLVS------------- 74

  Fly    94 AKGQKDKDKDKNKGRVKVAHQTIEALHNSALGIANNEGLSALHLAAQNGHNQSSRELLLAGADPD 158
                                      ....|.:.:.|..:.|..|.|......:..||..||||:
Human    75 --------------------------RRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGADPN 113

  Fly   159 VRNNYGDTPLHTACRYGHAGVSRILLS-----ALCDPN-----------------------KTNL 195
            :.:.:|.|.||.|.......:...|||     ..|..|                       |.|:
Human   114 ITDVFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKNEYQPLLLAVSRRKVKMVEFLLKKKANV 178

  Fly   196 N-----GDTALHITCAMGRRKLTRILLEADARLGIKNAQGDCPMHIAIRKNYREIIEILNTPKK- 254
            |     |.:||.:...:|.:.:..:||:.:..:..::..|......|.....|.|.:::...|:
Human   179 NAIDYLGRSALILAVTLGEKDIVILLLQHNIDVFSRDVYGKLAEDYASEAENRVIFDLIYEYKRK 243

  Fly   255 ------IRNRKEKPKEGGSRSDKDRDRERDVVDKGINWSPYGCHYFPDPRAFPSPKLETLPKEPL 313
                  |.:....|::  .|::|....::|.|.........|    |......|.|   .|.|..
Human   244 RYEDLPINSNPVSPQK--QRAEKATSDDKDSVSNIATEIKEG----PISGTVSSQK---QPAEKA 299

  Fly   314 KSGEQYFL-DLAGHIHKGPVSVGNTCYCGPFFRHIENKLNCNRKSLKKYVHKTKERL-------- 369
            .|.|:..: ::|..|.:|..|               ..::..::|.:|.:.|.|..|
Human   300 TSDEKDSVSNIATEIKEGQQS---------------GTVSPQKQSAQKVIFKKKVSLLNIATRIM 349

  Fly   370 -GHKVQAL------AIKT-NDQIEQL--TRTMIEDRLRC---ESKRQHLSEFLRRGEPMRSTFDQ 421
             |.|...:      |.|| :|:.:..  |.|.|:|.|:|   .|::|         :.:::|.|:
Human   350 GGGKSGTVSSQKQPASKTASDKTDSALNTATEIKDGLQCGTVSSQKQ---------QALKATTDE 405

  Fly   422 QNKSSRIERTMSRCRSLELLENNHEGGRLTNSRSVDVLEDQAVEAIVHRSAEVQVDSDSDDDSNE 486
            :...|.|        :.|:.:....|       :|...:..|::|         ...:.|..||.
Human   406 EGSVSNI--------ATEIKDGEKSG-------TVSSQKKPALKA---------TSDEKDSFSNI 446

  Fly   487 ARDEEEAEVGDKDQVQEEAEPEEHSKLDELKLDFLKVSERLGVLLEKTTLIMERDSEQESKRQLS 551
            .|::::.|:  ...|..:..|       .||...:|....|.:..||        .:.|..|.:|
Human   447 TREKKDGEI--SRTVSSQKPP-------ALKATSVKEDSVLNIAREK--------KDGEKSRTVS 494

  Fly   552 SLSPPYNPHPRAESAQLREDKESVNSPNFDEYANVIRRYPNSSET------SNPSQNSNSWDWEA 610
            ...||       .....|::|:|:        .|:.|...:..:|      ..||..:.|...::
Human   495 FEQPP-------GLKATRDEKDSL--------LNIARGKKDGEKTRRVSSHKQPSLKATSDKEDS 544

  Fly   611 SPTGSNPHPDYNKYYQRIGRGENMLNSVIKALRKDASFADLGKEETAVNETAEGMGGDKLLYKEQ 675
            .|..:....|            ..::..:...::.|..|...|:::..|...|...|
Human   545 VPNMATETKD------------EQISGTVSCQKQPALKATSDKKDSVSNIPTEIKDG-------- 589

  Fly   676 ASEAAGISNLMKRQPLCLEDNYPVMSNLFYSNPIMEYAEETEVRQNGNESMSKV--EIRNSEIK- 737
             .::..:|:  ::||..                     :.|.|::   :|:|.:  ||::.:|:
Human   590 -QQSGTVSS--QKQPAW---------------------KATSVKK---DSVSNIATEIKDGQIRG 627

  Fly   738 ---CLKKP---NAGQVRDMVAQL---------QNTIDSNRQDSQTAHVIAARSHSRLN------- 780
               ..::|   ..|..:|.|:.:         ..|:...:|.:|  .||..:..|.||
Human   628 TVSSQRRPALKTTGDEKDSVSNIAREIKDGEKSGTVSPQKQSAQ--KVIFKKKVSLLNIATRITG 690

  Fly   781 ---------NNFHHLEGTSSN 792
                     .|...|:.|..|
Human   691 GGKSGTEYPENLRTLKATIEN 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgo	NP_610614.1	ANK	22..184	CDD:238125	31/154 (20%)
		ANK repeat	24..55	CDD:293786	7/25 (28%)
		Ank_2	29..161	CDD:289560	26/131 (20%)
		ANK repeat	59..128	CDD:293786	8/68 (12%)
		ANK	126..249	CDD:238125	33/155 (21%)
		ANK repeat	130..161	CDD:293786	10/30 (33%)
		Ank_2	135..227	CDD:289560	28/124 (23%)
		ANK repeat	163..194	CDD:293786	11/58 (19%)
		ANK repeat	196..227	CDD:293786	7/35 (20%)
ANKRD36B	NP_001380868.1	ANKYR	17..209	CDD:223738	45/224 (20%)
		ANK 1	19..48		7/23 (30%)
		Ank_2	24..116	CDD:403870	26/131 (20%)
		ANK repeat	24..50	CDD:293786	7/25 (28%)
		ANK 2	52..81		8/68 (12%)
		ANK repeat	54..83	CDD:293786	8/67 (12%)
		ANK repeat	85..116	CDD:293786	10/30 (33%)
		ANK 3	85..114		10/28 (36%)
		ANK 4	118..147		8/28 (29%)
		ANK repeat	118..142	CDD:293786	8/23 (35%)
		ANK repeat	151..182	CDD:293786	4/30 (13%)
		ANK 5	151..180		3/28 (11%)
		ANK repeat	184..215	CDD:293786	6/30 (20%)
		ANK 6	184..213		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..307		14/66 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..607		61/366 (17%)
		CCDC158	712..>1342	CDD:318193	157/866 (18%)
		CCDC144C	949..1240	CDD:405585
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I5159
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050