DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dgo and Ankrd6

DIOPT Version :9

Sequence 1:	NP_610614.1	Gene:	dgo / 36139	FlyBaseID:	FBgn0086898	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001128441.1	Gene:	Ankrd6 / 500430	RGDID:	1583731	Length:	713	Species:	Rattus norvegicus

Alignment Length:	669	Identity:	163/669 - (24%)
Similarity:	254/669 - (37%)	Gaps:	202/669 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSSNWTSLHEAVAAGDDRRVEGLLFSNADRLARESVQGNTPLHEAASRGFSRCVKLICTPPTPPA 86
            |..:.|:||.|...|:...:..|:.... .|.|:...|||.|||||..|||:..||:       .
  Rat    72 DDGDQTALHRATVVGNTEILTALIREGC-ALDRQDKDGNTALHEAAWHGFSQSAKLL-------V 128

  Fly    87 SSGVGKAAKGQKDKDKDKNKGRVKVAHQTIEALHNSALGIANNEGLSALHLAAQNGHNQSSRELL 151
            .:|....|:                                |..|.:|||||.||.|:||:|.||
  Rat   129 KAGANVLAR--------------------------------NKAGNTALHLACQNSHSQSTRVLL 161

  Fly   152 LAGADPDVRNNYGDTPLHTACRYGHAGVSRILLSALCDPNKTNLNGDTALHITCAMGRRKLTRIL 216
            |.|:..|::||.|||.||.|.||.|..|.|:||||.|..::.|..||||||:..|:..:|:.:||
  Rat   162 LGGSRADLKNNAGDTCLHVAARYNHLSVVRLLLSAFCSVHEKNQAGDTALHVAAALNHKKVVKIL 226

  Fly   217 LEADARLGIKNAQGDCPMHIAIRKNYREIIEIL---------NTPKKIRNRKEKPKE-------- 264
            |||.|...:.|..|..|:..|...:..|:..:|         :..:.:|.|:|:.||
  Rat   227 LEAGADTTLVNNAGQTPLETARYHDNPEVALLLTKAPQILRFSRGRSLRKRRERLKEERRAQSVP 291

  Fly   265 -------GGS------------------------------RSDKDRDRERDVV------------ 280
                   .||                              |.|:.|.:.|..|
  Rat   292 RDEVAQSKGSVSAGDTPSSEQAVPEKEEARRDCPPASQEPRKDERRRKSRPEVSALSDPTPAADQ 356

  Fly   281 ----DKGIN-------------WSPYGCHYFPDPRAFPSPKLETLPKEPLKSGEQYFLDLAGHIH 328
                .|.::             |||      |.|..|.:.:|.||.:     ||.      |.:.
  Rat   357 QPGHQKNLHGHHHQKKKSRHRCWSP------PPPHGFRAYQLYTLYR-----GED------GKVM 404

  Fly   329 KGPVSVGNTCYCGPFFRHIENKLNCNRKSLKKYVHKTKERLGHKVQALAIKTNDQIEQLTRTMIE 393
            :.|:   ..|.|.|....:||:|....:.|:..:...::::..|:..:..|:..|:..|.:.|:|
  Rat   405 QAPI---KGCRCEPLINKLENQLEAAVEELRAELGTVQDKVNTKLGHMESKSQHQMCVLDKLMVE 466

  Fly   394 ----DRLRCESK-RQHLSEFLRRGEPMRSTFDQQNKSSRIERTMSRCRSLELLENNHEGGRLTNS 453
                :|..|.:: :||.:...:.||..:.:...:.||    ..|.:.::|||        ||:.
  Rat   467 RLSAERTECLNRLQQHAAAEKQEGEKRQMSLVDELKS----WCMLKIQNLEL--------RLSG- 518

  Fly   454 RSVDVLEDQAVEAIVHRSAEVQVDSDSDDDSNE---------ARDEEEAEVGDKDQV-------- 501
                       |:...|:......|||....::         |.|.....|..||:.
  Rat   519 -----------ESRTFRAKSTPSPSDSSPAVDQPVVAAGPGAASDSSSQVVRPKDKALNATAVPR 572

  Fly   502 -QEEAEPEE--HSKLDELKLDFLKVSERLG-------VLLEKTTLIMERDSEQESKRQLSSLSPP 556
             |:|..|.:  .|.|.::|   ...:.|||       |.....|....|..:.:.:.|..:.|.|
  Rat   573 HQQELLPSDCTGSGLRKVK---APAASRLGDQQTGSCVNRGTQTKKSARGGQTKHRGQQPTASSP 634

  Fly   557 YNPHPRAESAQLREDKESV 575
            ....|.|.|:..|:..:::
  Rat   635 SGQQPSAASSDARDASQAL 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgo	NP_610614.1	ANK	22..184	CDD:238125	55/161 (34%)
		ANK repeat	24..55	CDD:293786	7/30 (23%)
		Ank_2	29..161	CDD:289560	40/131 (31%)
		ANK repeat	59..128	CDD:293786	15/68 (22%)
		ANK	126..249	CDD:238125	56/122 (46%)
		ANK repeat	130..161	CDD:293786	17/30 (57%)
		Ank_2	135..227	CDD:289560	48/91 (53%)
		ANK repeat	163..194	CDD:293786	16/30 (53%)
		ANK repeat	196..227	CDD:293786	14/30 (47%)
Ankrd6	NP_001128441.1	PHA03095	29..>265	CDD:222980	81/232 (35%)
		ANK repeat	41..72	CDD:293786	163/669 (24%)
		ANK repeat	74..105	CDD:293786	8/31 (26%)
		ANK repeat	107..138	CDD:293786	15/69 (22%)
		ANK repeat	141..171	CDD:293786	17/29 (59%)
		ANK repeat	173..204	CDD:293786	16/30 (53%)
		ANK repeat	206..237	CDD:293786	14/30 (47%)
		PLN02847	<545..706	CDD:178439	24/112 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346225
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_111903
Panther	1	1.100	-	-	LDO	PTHR24203
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.930