DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dgo and ANKRD18B

DIOPT Version :9

Sequence 1:	NP_610614.1	Gene:	dgo / 36139	FlyBaseID:	FBgn0086898	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001340361.1	Gene:	ANKRD18B / 441459	HGNCID:	23644	Length:	1181	Species:	Homo sapiens

Alignment Length:	1042	Identity:	196/1042 - (18%)
Similarity:	359/1042 - (34%)	Gaps:	294/1042 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 NW--TSLHEAVAAGDDRRVEGLL---FSNADRLARESVQGNTPLHEAASRGFSRCVKL------- 77
            :|  ..:|.|...||...||..|   |.:.|...|:.   .|.||.|.:.|..:.|.|
Human    32 DWELRKIHRAAIKGDAAEVEHCLTRRFRDLDVRDRKD---RTVLHLACAHGRVQVVTLLLDRKCQ 93

  Fly    78 --IC-----TPPTPPASSGVGKAA-------------KGQKDKDKD-----------KNKG---- 107
              ||     ||        :.||.             :|.....||           .|:|
Human    94 INICDRLNRTP--------LMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLA 150

  Fly   108 -RVKVAHQTIEALHNSALGIANNEGLSALHLAAQNGHNQSSRELLLAG-ADPDVRNNYGDTPLHT 170
             |:...|..||||        |.||.:.| |.|.|...|...|.||.. |:....:|:..|.|..
Human   151 ERLLSHHANIEAL--------NKEGNTPL-LFAINSRRQHMVEFLLKNQANIHAVDNFKRTALIL 206

  Fly   171 ACRYGHAGVSRILLSALCDPNKTNLNGDTALHITCAMGRRKLTRILLEADARLGIKNAQGDCPMH 235
            |.::..:.:..:||......:..::.|.||.........|.:.:.:||...:: :||...:....
Human   207 AVQHNLSSIVTLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKM-LKNHLRNDNQE 270

  Fly   236 IAIRKNYREIIEILNTPKKIRNRKEKPKEGGSRSDKDRDRERDVVDKGINWSP------------ 288
            .|..|  .|.::.....||::.|||..||...:...:..:||  :::..|..|
Human   271 TAAMK--PENLKKRKKRKKLKKRKEGAKEHNLKVASEEKQER--LERSENKQPQDSQSYGKKKDE 331

  Fly   289 -YGCHYFPDPRAFPSPKLETLPKEPLKSGEQYFLDLAGHIHKGPVSVGNTCYCGPFFRHIENKLN 352
             :|........|....:|..:..:.|:..::|..::     |....:.         .:.|..:.
Human   332 MFGNFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEI-----KSITEIN---------ANFEKSVR 382

  Fly   353 CNRKSLKKYVHK------------------------TKERLGHKVQA----LAIKTNDQIEQLTR 389
            .|.:.:.|.|.:                        .||||..:|::    ||...|:..|.|.|
Human   383 LNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHSNLATAINEYNEILER 447

  Fly   390 TMIE-------DRLRCESKRQHLSEFLRRGEPM-------RSTFD------QQNKSSRIERTMSR 434
            ..:|       |..|.|:...::|:...:.|.:       |..|:      ::.:.:..|:|::
Human   448 KDLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLA- 511

  Fly   435 CRSLEL-----------LENNHEGGRLTNSRSVDVLEDQAVEAIVHRSAEVQVDSDSDDDSNEAR 488
            ..|::|           ::..|..|....|:|:. .::.:.|.|..|..|..:.....:|:.:..
Human   512 LESVQLDLKQAQHRIKEMKQMHPNGEAKESQSIG-KQNSSEERIRQRELENLLLERQLEDARKEG 575

  Fly   489 DEEEAEV--------GDKDQVQEEAEPE---EHSKLDELKLDFLKVSERLGVLLEKTTLIMERDS 542
            |.:|..:        ..|:.:.||...|   |::.|.|..|.:.|......|::        |:.
Human   576 DNKEIVINIHRDCLENGKEDLLEERNKELMNEYNYLKEKLLQYEKEKAEREVIV--------REF 632

  Fly   543 EQESKRQLSSLSPPYNPHPRAESAQLREDK-----------ESVNSPNFDEYANVIRRYPNSSET 596
            ::|....|...|...:|........:..|:           |.......:|:..|.......:.|
Human   633 QEELVDHLKKFSMSESPLEGTSHCHINLDETWTSKKKLFQVEIQPEEKHEEFRKVFELISLLNYT 697

  Fly   597 SNPSQNSNSWDWEASPTGSNPHPDYNKYYQRIGRGENMLNS---------------------VIK 640
            ::..:..|. :.|...||         |.:.:....||||:                     :.|
Human   698 ADQIRKKNR-ELEEEATG---------YKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFK 752

  Fly   641 ALRKDASFADLGKEETAVNETAEGMGGD-KLLYKEQASEAAGISNLMKRQPLC--LEDNYPVM-- 700
            .|::  .|.||..|:.||:.....:..| ::|::|       :.::.|.|..|  ||.:..::
Human   753 KLKQ--KFDDLMAEKEAVSSKCVNLAKDNEVLHQE-------LLSMGKVQEKCEKLEKDKKMLEE 808

  Fly   701 ----------SNLFYSNPIMEYAEETEVR-QNGNESMSKVEIR-----NSEIKCLKKPNAGQVRD 749
                      .::.....:.||..|.:.| ....|.:.::.::     ..:::.|.|.|...::.
Human   809 KVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKK 873

  Fly   750 MVAQLQNT-------------IDSNRQDSQTAHVIAARSHSRLNNNFHHLEGTSSNPSPTYSIPH 801
            ....|::.             :.:..::.:.|..:|.:::|.::...     |.|:.    .|..
Human   874 KELTLKDVECKFSKMKTAYEDVTTELEEYKEAFAVALKANSSMSEKI-----TKSDK----KIAV 929

  Fly   802 RSSAQFGLPERHIPKDAYFHELPHRPPIPQTP------QRRLHSGYVPNASLYRSEDLYVGRIPH 860
            .|:..|...||   .:.:...||.||. |:.|      ...|:..|:|..::         |||.
Human   930 ISTKLFMEKER---MEYFLSTLPMRPD-PELPCVENLNSIELNRKYIPKMAI---------RIPT 981

  Fly   861 PN 862
            .|
Human   982 SN 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgo	NP_610614.1	ANK	22..184	CDD:238125	51/207 (25%)
		ANK repeat	24..55	CDD:293786	10/34 (29%)
		Ank_2	29..161	CDD:289560	46/178 (26%)
		ANK repeat	59..128	CDD:293786	24/111 (22%)
		ANK	126..249	CDD:238125	29/123 (24%)
		ANK repeat	130..161	CDD:293786	11/31 (35%)
		Ank_2	135..227	CDD:289560	21/92 (23%)
		ANK repeat	163..194	CDD:293786	5/30 (17%)
		ANK repeat	196..227	CDD:293786	6/30 (20%)
ANKRD18B	NP_001340361.1	Ank_4	34..88	CDD:316185	17/56 (30%)
		ANK repeat	38..65	CDD:293786	9/26 (35%)
		ANK	62..187	CDD:238125	35/144 (24%)
		ANK repeat	69..98	CDD:293786	8/28 (29%)
		ANK repeat	100..131	CDD:293786	5/38 (13%)
		ANK	128..253	CDD:238125	32/133 (24%)
		ANK repeat	133..164	CDD:293786	8/38 (21%)
		ANK repeat	166..197	CDD:293786	11/31 (35%)
		ANK repeat	199..230	CDD:293786	5/30 (17%)
		CCDC144C	335..625	CDD:317340	52/305 (17%)
		SMC_N	<468..918	CDD:330553	76/478 (16%)
		DUF3496	873..977	CDD:314818	20/116 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I5159
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050