DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dgo and ankrd6b

DIOPT Version :9

Sequence 1:	NP_610614.1	Gene:	dgo / 36139	FlyBaseID:	FBgn0086898	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_021324047.1	Gene:	ankrd6b / 378477	ZFINID:	ZDB-GENE-030916-4	Length:	750	Species:	Danio rerio

Alignment Length:	669	Identity:	164/669 - (24%)
Similarity:	260/669 - (38%)	Gaps:	177/669 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSSNWTSLHEAVAAGDDRRVEGLLFSNADRLARESVQGNTPLHEAASRGFSRCVKLICTPPTPPA 86
            |..:.|:||.|...|:...:..|: .....|.|:...|||.|||||..|||:.|||:       .
Zfish    96 DDGDQTALHRAAVVGNTDVISALV-QEGCALDRQDKDGNTALHEAAWHGFSQTVKLL-------V 152

  Fly    87 SSGVGKAAKGQKDKDKDKNKGRVKVAHQTIEALHNSALGIANNEGLSALHLAAQNGHNQSSRELL 151
            .:|....||                                |..|.:|||||.||||.||.|.||
Zfish   153 KAGANVHAK--------------------------------NKAGNTALHLACQNGHVQSCRVLL 185

  Fly   152 LAGADPDVRNNYGDTPLHTACRYGHAGVSRILLSALCDPNKTNLNGDTALHITCAMGRRKLTRIL 216
            |.|:.||.:|:.|||.||.:.||.|..|.|.||.|:|.....|..|||||||...:..||..|:|
Zfish   186 LGGSRPDSKNSVGDTCLHVSARYNHVSVIRALLGAICSVTDRNHTGDTALHIAATLNHRKTVRML 250

  Fly   217 LEADARLGIKNAQGDCPMHIAIRKNYREIIEIL-------NTPKKIRNRKEKPKEGGSRSDKDRD 274
            |||.|...|||..|:..:..|...|..|:..:|       :..:.:|.|::|.|..|......||
Zfish   251 LEAGADSRIKNNTGETALDQARENNSPEVALLLTKAPQSFSRGRTVRKRRDKMKTEGRAQSVPRD 315

  Fly   275 ----RERDVVDKGINWSP----YG---------------------CH--------------YFPD 296
                |:.|      :.||    :|                     ||              :.|:
Zfish   316 EMLPRKCD------SASPAQDTHGSDGSLRRTDNMFLTEPRTNKNCHRKARDRLSPSDALIHRPN 374

  Fly   297 PRAFPSPKLET-------LPKEPLKSGEQY-----FLDLAGHIHKGPVSVGNTCYCGPFFRHIEN 349
            .::.|..|.:|       :|..|..:.:.|     :....|.|.:.|:   |.|.|.|....:||
Zfish   375 KQSDPKKKSKTERSSPSAVPPPPPHNYKAYQLYTLYRGKDGKIMQAPL---NGCRCEPLISKLEN 436

  Fly   350 KLNCNRKSLKKYVHKTKERLGHKVQALAIKTNDQIEQLTRTMIE----DRLRCESKRQHLSEFLR 410
            :|...::.::..:|..:|.:..|:..:..|:..||..|.:..:|    :|:.|      |....:
Zfish   437 QLMATKEEMQSEIHTVQELMNSKIGQMDRKSKHQIRALDKMTLERVSAERIEC------LHRIDK 495

  Fly   411 RGEPMRSTFDQQNKSSRIER-----TMSRCRSLEL-LENNHEGGRLTNSRSV-DVLED-----QA 463
            |.  ::...:.:.:.:.:.:     .:|:.:|||. |.......||..|.|: |.|.|     :.
Zfish   496 RA--VQERLEAEKRQTSVVKDLKNWCLSKIQSLETRLSGERVDSRLQRSSSLTDTLSDCTPVLEP 558

  Fly   464 VEAIVHRS-----------------AE--------VQVDSDSDDDSNEARDEEEAEVGDKDQVQE 503
            ..|..|.|                 ||        ::||:.:|..|::.:...::....:.:.:.
Zfish   559 SRAAPHPSPSAEPTDAGETAAASSCAEDAPARYYVIEVDASADKPSSQNQSAPQSPCIVRPKQRS 623

  Fly   504 EAEPEEHSKLDELKLDFLKVSERLGV----LLEKTTLIMERDSEQESKRQLSSLSPPYNPHPRAE 564
            .|..:.|...||        ||...|    ..|..|:...|...:.|.:.|:     ....|.|.
Zfish   624 RACSDPHQLRDE--------SEERSVEPRPAAEHRTIRRHRAKSKPSAQSLT-----LQTCPAAA 675

  Fly   565 SAQLREDKESVNSPNFDEY 583
            .....::::::::....:|
Zfish   676 EGAFAQERDNMHALEVTQY 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgo	NP_610614.1	ANK	22..184	CDD:238125	57/161 (35%)
		ANK repeat	24..55	CDD:293786	7/30 (23%)
		Ank_2	29..161	CDD:289560	44/131 (34%)
		ANK repeat	59..128	CDD:293786	17/68 (25%)
		ANK	126..249	CDD:238125	58/122 (48%)
		ANK repeat	130..161	CDD:293786	19/30 (63%)
		Ank_2	135..227	CDD:289560	49/91 (54%)
		ANK repeat	163..194	CDD:293786	14/30 (47%)
		ANK repeat	196..227	CDD:293786	16/30 (53%)
ankrd6b	XP_021324047.1	ANK	65..185	CDD:238125	40/128 (31%)
		ANK repeat	65..96	CDD:293786	164/669 (25%)
		ANK repeat	98..129	CDD:293786	8/31 (26%)
		ANK	126..251	CDD:238125	64/163 (39%)
		ANK repeat	131..162	CDD:293786	17/69 (25%)
		ANK repeat	164..195	CDD:293786	19/30 (63%)
		ANK repeat	197..228	CDD:293786	14/30 (47%)
		Ank_5	214..>293	CDD:330893	29/78 (37%)
		ANK repeat	230..261	CDD:293786	16/30 (53%)
		DNA_pol3_gamma3	<554..721	CDD:331207	24/154 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587191
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25412
orthoMCL	1	0.900	-	-		OOG6_111903
Panther	1	1.100	-	-	LDO	PTHR24203
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10493
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.960