DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dgo and ANKRD30B

DIOPT Version :9

Sequence 1:	NP_610614.1	Gene:	dgo / 36139	FlyBaseID:	FBgn0086898	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001354536.1	Gene:	ANKRD30B / 374860	HGNCID:	24165	Length:	1525	Species:	Homo sapiens

Alignment Length:	709	Identity:	142/709 - (20%)
Similarity:	239/709 - (33%)	Gaps:	174/709 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LHEAASRGFSRCVKLICTPPTPPASSGVGKAAKGQKDKDKDKNKGRVKVAHQTIEALHNSALGIA 127
            :|.|||||  :..||        ....|||.......:|..|.
Human    42 IHTAASRG--QVQKL--------EKMTVGKKPVNLNKRDMKKR---------------------- 74

  Fly   128 NNEGLSALHLAAQNGHNQSSRELLLAGADPDVRNNYGDTPLHTACRYGHAGVSRILLSALCDPNK 192
                 :|||.|..|||.:....|:......:|.:..|.|||..|.:......:.||:.|..|.|.
Human    75 -----TALHWACVNGHAEVVTFLVDRKCQLNVLDGEGRTPLMKALQCEREACANILIDAGADLNY 134

  Fly   193 TNLNGDTALHITCAMGRRKLTRILLEADARLGIKNAQGDCPMHIAIRKNYREIIEILNTPKKIRN 257
            .::.|:||||.........:...||...|.:.::|.....|:.:||:|..::.:|.|.|.....|
Human   135 VDVYGNTALHYAVYSENLLMVATLLSYGAVIEVQNKASLTPLLLAIQKRSKQTVEFLLTKNANAN 199

  Fly   258 RKEKPK---------EGGS-------RSDKDRDRERDVVDKGINWSPY----GCHYFPDPRAFPS 302
            ...:.|         ||.|       :.:.|...| |:  .||....|    |.:|......
Human   200 AFNESKCTALMLAICEGSSEIVGMLLQQNVDVFAE-DI--HGITAERYAAACGVNYIHQQLL--- 258

  Fly   303 PKLETLPKEPLKSGEQYFLDLAGHIHKGPVSVGNTCYCGPFFRHIENKLNCNRKSLKKYVHKTKE 367
            ..:..|||.|..:..:            ..|.|......|......:......:.......:..|
Human   259 EHIRKLPKNPQNTNPE------------GTSTGTPDEAAPLAERTPDTAESLLEKTPDEAARLVE 311

  Fly   368 RLGHKVQALAIKTNDQIEQLTRTMIEDRLRCESKRQHLSEFLRRGEPMRSTFDQQ---------- 422
            ....|:|.|...|:.:.||.|.......||...:......:..:....:.|::::
Human   312 GTSAKIQCLGKATSGKFEQSTEETPRKILRPTKETSEKFSWPAKERSRKITWEEKETSVKTECVA 376

  Fly   423 ----NKSSRIERTMSRCRSLELLENNHEGGRLTNSRSVDVLEDQAVEAI--------VHRSAEVQ 475
                ||:..:|:..|...:....|.:.:.     |.:|||   .:||.|        :..|...:
Human   377 GVTPNKTEVLEKGTSNMIACPTKETSTKA-----STNVDV---SSVEPIFSLFGTRTIENSQCTK 433

  Fly   476 VDSDSD-----------------DDSNEARDEEEAEVGDKDQV---QEEAEPEEHSKLDELKLDF 520
            |:.|.:                 .|:...:|.:......:||:   :.:.|.:|....|.
Human   434 VEEDFNLATKIISKSAAQNYTCLPDATYQKDIKTINHKIEDQMFPSESKREEDEEYSWDS----- 493

  Fly   521 LKVSERLGVLLE---KTTLIMERDSEQ---ESKRQLSSLSPPYNPHPRAESAQLREDKESVNSPN 579
                   |.|.|   ||.:.:.....|   |..|::..|  |..|.....:.::   :::|.:..
Human   494 -------GSLFESSAKTQVCIPESMYQKVMEINREVEEL--PEKPSAFKPAVEM---QKTVPNKA 546

  Fly   580 F----DEYANVIRRYPNSSETSNPSQNSNSWDWEASP--TGSN-----PHPDYNKYYQRIGRGEN 633
            |    ::.....:.:|  ||:.......||||.| ||  |.|.     |...:.|.:..:. |:.
Human   547 FELKNEQTLRAAQMFP--SESKQKDDEENSWDSE-SPCETVSQKDVYLPKATHQKEFDTLS-GKL 607

  Fly   634 MLNSVIKALRKDASFADLGKEETAVNETAEGMGGDKLLYKEQASEAAGISNLMKRQPLC 692
            ..:.|...|.|..    .|::.:..|:..|..  |:..:|.::.:..|   |:|  |.|
Human   608 EESPVKDGLLKPT----CGRKVSLPNKALELK--DRETFKAESPDKDG---LLK--PTC 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgo	NP_610614.1	ANK	22..184	CDD:238125	28/120 (23%)
		ANK repeat	24..55	CDD:293786
		Ank_2	29..161	CDD:289560	22/97 (23%)
		ANK repeat	59..128	CDD:293786	13/64 (20%)
		ANK	126..249	CDD:238125	33/122 (27%)
		ANK repeat	130..161	CDD:293786	9/30 (30%)
		Ank_2	135..227	CDD:289560	26/91 (29%)
		ANK repeat	163..194	CDD:293786	10/30 (33%)
		ANK repeat	196..227	CDD:293786	8/30 (27%)
ANKRD30B	NP_001354536.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I5159
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050