DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dgo and ANKRD62

DIOPT Version :9

Sequence 1:	NP_610614.1	Gene:	dgo / 36139	FlyBaseID:	FBgn0086898	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001264262.1	Gene:	ANKRD62 / 342850	HGNCID:	35241	Length:	917	Species:	Homo sapiens

Alignment Length:	873	Identity:	167/873 - (19%)
Similarity:	301/873 - (34%)	Gaps:	230/873 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LHEAVAAGDDRRV-EGLLFSNADRLARESVQGNTPLHEAASRGFSRCVKLICTPPTPPASSGVGK 92
            :|:|..|||..:| |.:|....|...|:. :..|.|..|.:.|....|..:.
Human    42 IHKAAIAGDVNKVMESILLRLNDLNDRDK-KNRTALLLACAHGRPGVVADLV------------- 92

  Fly    93 AAKGQKDKDKDKNKGRVKVAHQTIEAL-------HNSALGIANNEGLSALHLAAQNGHNQSSREL 150
            |.|.|.:....:|:..:..|.|..|.:       |.:...:.:..|.:|||.|..|.:...:|:|
Human    93 ARKCQLNLTDSENRTALIKAVQCQEEVCASILLEHGANPNVRDMYGNTALHYAIDNENISMARKL 157

  Fly   151 LLAGADPDVRNNYGDTPLHTACRYGHAGVSRILLSALCDPNKTNLNGDTALHITCAMGRRKLTRI 215
            |..|||.:.|:..|.|.|..|.......:...||....|....:..|.|||.:....|...:...
Human   158 LAYGADIEARSQDGHTSLLLAVNRKKEQMVAFLLKKKPDLTAIDNFGRTALILAARNGSTSVVYQ 222

  Fly   216 LLEADARLGIKNAQGDCPMHIAIRKNYREIIEILNTPKKIRNRKEKPKEGGSRSDKDRDRERDVV 280
            ||:.:..:..::..|......|:...::.|..:::..|  .|::.|     |..:.:.:::.::.
Human   223 LLQHNIDVFCQDISGWTAEDYAVASKFQAIRGMISEYK--ANKRCK-----SLQNSNSEQDLEMT 280

  Fly   281 DKGINWSPYGCHYFPDPRAFPSPKLETLPKEPLKSGEQYFLDLAGHIHKGPVSVGNTCYCGPFFR 345
            .:|......||.       ...|::|    |.:|......::::.::
Human   281 SEGEQERLEGCE-------SSQPQVE----EKMKKCRNKKMEVSRNV------------------ 316

  Fly   346 HIENKLNCNRKSLKKYVHKTKERLGHKVQALAIKTNDQIEQLTRTMIEDRLRCESK---RQHLSE 407
            |.::..|.| ..:.:.:||.|.|.....|:.. |.|.:.::|.|....::.:.:|:   ...|::
Human   317 HADDSDNYN-DDVDELIHKIKNRKPDNHQSPG-KENGEFDRLARKTSNEKSKVKSQIYFTDDLND 379

  Fly   408 FLRRGEPMRST-----FDQQNKSSRIERTMSRCRSLELLENNHEGGRLTNSRSVDVLEDQA--VE 465
            .....|.....     .|.:|....||::...|:....|..: :.......||:   |||.  .|
Human   380 ISGSSEKTSEDDELPYSDDENFMLLIEQSGMECKDFVSLSKS-KNATAACGRSI---EDQKCYCE 440

  Fly   466 AI------VHRSAEVQVDSDSDDDSNEARDEEEAEVGDKD--------QVQEEAEPEEHSKLDEL 516
            .:      :..:..|.....|:.|..:::.|.:...|.|.        |.||    ||..|.:||
Human   441 RLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQE----EERIKAEEL 501

  Fly   517 ---KLDFLKVSE---RLGVLLEKTTLIMERDSEQESKRQLSSLSPPYNPHPRA------------ 563
               .::.||:.|   |....::|.:.:..:..|.|.|...|:.:..::.|.|.
Human   502 YEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQNFHTHERERDLWQENHLMRD 566

  Fly   564 ESAQLREDKESVNSPNFDEYANVIRRYPNSSETSNPSQNSNSWDWEASPTGSNPHPDYNKYYQRI 628
            |.|:||.:.:::...|              .||.                        |||::.|
Human   567 EIARLRLEIDTIKHQN--------------QETE------------------------NKYFKDI 593

  Fly   629 GRGENMLNSVIKALRKDASFADLGKEETAVNETAEGMGGDKLLYKEQASEAAGISNLMKRQPLCL 693
                    .:||...:|.. ..|.:.|.|:.:|                    |:...|...:.:
Human   594 --------EIIKENNEDLE-KTLKRNEEALTKT--------------------ITRYSKELNVLM 629

  Fly   694 EDNYPVMSNLFYSNPIMEYAEETEVRQNGNESMSKVEIRNSEIKCL-------KKPNAGQVRDMV 751
            ::|..:.|.|                |...:|||::|......:|.       ........||:.
Human   630 DENTMLNSEL----------------QKEKQSMSRLETEMESYRCRLAAALCDHDQRQSSKRDLQ 678

  Fly   752 AQLQNTIDS--NRQDSQTAHVIAARSHSRLNNNFHHLEGTSSNPSPTYSIPHRSSAQFGLP---- 810
            ...|:|::.  :.|:...:|:      ..|:......|.|||                ||.
Human   679 LAFQSTVNEWCHLQEDTNSHI------QILSQQLSKAESTSS----------------GLETELH 721

  Fly   811 -ERHIPKDAYFHELPHRPPIPQTPQRRL 837
             ||...|:...| :.|...:....||||
Human   722 YEREALKEKTLH-IEHMQGVLSRTQRRL 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgo	NP_610614.1	ANK	22..184	CDD:238125	40/162 (25%)
		ANK repeat	24..55	CDD:293786	9/26 (35%)
		Ank_2	29..161	CDD:289560	35/139 (25%)
		ANK repeat	59..128	CDD:293786	13/75 (17%)
		ANK	126..249	CDD:238125	30/122 (25%)
		ANK repeat	130..161	CDD:293786	12/30 (40%)
		Ank_2	135..227	CDD:289560	25/91 (27%)
		ANK repeat	163..194	CDD:293786	7/30 (23%)
		ANK repeat	196..227	CDD:293786	7/30 (23%)
ANKRD62	NP_001264262.1	Ank_4	42..92	CDD:290365	15/50 (30%)
		ANK repeat	42..69	CDD:293786	9/26 (35%)
		ANK	66..191	CDD:238125	31/138 (22%)
		ANK 1	71..100		8/41 (20%)
		ANK repeat	73..102	CDD:293786	8/41 (20%)
		Ank_2	76..167	CDD:289560	24/103 (23%)
		ANK repeat	104..135	CDD:293786	5/30 (17%)
		ANK 2	104..133		5/28 (18%)
		ANK	132..256	CDD:238125	30/123 (24%)
		ANK repeat	137..167	CDD:293786	12/29 (41%)
		ANK 3	137..166		12/28 (43%)
		Ank_2	142..234	CDD:289560	25/91 (27%)
		ANK repeat	170..201	CDD:293786	7/30 (23%)
		ANK 4	170..199		7/28 (25%)
		ANK repeat	203..234	CDD:293786	7/30 (23%)
		ANK 5	203..232		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	265..367		21/137 (15%)
		CCDC144C	561..846	CDD:291576	51/294 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000