DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dgo and Uaca

DIOPT Version :9

Sequence 1:	NP_610614.1	Gene:	dgo / 36139	FlyBaseID:	FBgn0086898	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001182493.1	Gene:	Uaca / 315732	RGDID:	1560011	Length:	1410	Species:	Rattus norvegicus

Alignment Length:	1255	Identity:	221/1255 - (17%)
Similarity:	363/1255 - (28%)	Gaps:	577/1255 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQHGSSRIPKQEA-------LPNAISGPDSSNWTS----LHEAVAAGDDRRVEGLLFSNADRLAR 54
            |:...||:.:|:|       .|.|::...|:.|..    |.:|...||..:|..:|........:
  Rat     1 MKSLKSRLWRQDAPGPTSPTSPTAVTSSLSAEWNKYDDRLMKAAERGDVEKVSSILAKKGVHPGK 65

  Fly    55 ESVQGNTPLHEAASRGFSRCVKLICTPPTPPASSGVGKAAKGQKDKDKDKNKGRVKVAHQTIEAL 119
            ..|:|.:..|..|::|...|:..|.|
  Rat    66 LDVEGRSAFHVVAAKGNLECLNAILT--------------------------------------- 91

  Fly   120 HNSALGIANNEGLSALHLAAQNGHN--------------------------------QSSRELLL 152
            |...:...::.|.:||||||:.||.                                .||.:||.
  Rat    92 HGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLC 156

  Fly   153 -AGADPDVRNNYGDTPLHTACRYGHAGVSRILLSALCDPNKTNLNGDTALHITCAMGRRKLTRIL 216
             .||..:.::..|.|||..|.:.....:.::|:....|.|..:....|||.:.|..|.|....:|
  Rat   157 DHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVL 221

  Fly   217 LEADARLGIKNAQG-DCPMHIAIRKNYREIIEILNT------------------PKKIRNRKEKP 262
            :...|.|.:.:|.| |...:..|..|. :|:.:|.|                  |.:.||.....
  Rat   222 VRNGADLTLLDALGHDSSYYARIGDNL-DILNLLKTASESTSKGGRRELWRKGPPLQQRNLSHTQ 285

  Fly   263 KEGGSRSD----------------------KDRDRERDVVDKGINWSPYGCH------------- 292
            .||..:|:                      |.:..:|.::|| :|......:
  Rat   286 DEGNVKSNQREHHSFQDLEMENEDLKEKLRKIQQEQRILLDK-VNGLQLQLNEEVMVADDLESER 349

  Fly   293 -----------------------------YF----PDPRAFPSPKLETLPKEPLKSGEQYFLD-- 322
                                         ||    |.|.::.|.:.|.:..   |.|:.|..|
  Rat   350 EKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHPGPGSYSSNRKEDMLH---KQGQMYTADSQ 411

  Fly   323 -----LAGHIHK----GPVSV---GNTCYCGPFFRHIENKLNCNRKSLKKYVH------------ 363
                 :..|:..    .|:.:   ..|.|.       ||::      |||.:.
  Rat   412 CTSPGVPPHMQSRSMLRPLELSLPSQTSYS-------ENEI------LKKELEAMRTFCDSAKQD 463

  Fly   364 --KTKERLGHKV---QALAIK-------TNDQIEQLTRTMIEDRLRCESKRQHLSE--------- 407
              |.:..|.|||   :|||::       :::||:||     ||.|:...||.:.||
  Rat   464 RLKLQNELAHKVAECKALALECERVKEDSDEQIKQL-----EDALKDVQKRMYESEGKVKQMQTH 523

  Fly   408 FL--------------------------------------------------------------- 409
            ||
  Rat   524 FLALKEHLTNEAATGSHRVIEELREQLKDMKGKYEGASAEVGKLRNQIKQSEMLVEGFKRDESRL 588

  Fly   410 -------------------RRG--------------------------EPMRSTF--DQQNKSSR 427
                               |||                          |.|:|:.  |...|:.|
  Rat   589 VEENKRLQKECSTCEIDRERRGRRVTELEGQLKELGAKLALSVPTETFESMKSSLSNDISEKAKR 653

  Fly   428 -----------------IERTMSRCRSLELLENNHE---------GGRL------------TNSR 454
                             ::|.:...|:..:....||         .|.|            |..:
  Rat   654 LAEVGRDYESSQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVTELTLKNQTLQK 718

  Fly   455 SVDVL--EDQAVEAIVH--------------------RSAEVQVD------SDSDDDSNEARDEE 491
            .|:.|  :::.:...||                    ::.:|.|:      ||:.....|.:.|.
  Rat   719 EVEKLYADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKAHDVNVEDLNKKLSDATQRYAEKKLEA 783

  Fly   492 EAEVGDKDQVQEEAE--------PEEHSK--------LDELKLDFLKVSERLGVLLEKTTLIMER 540
            |..:.:.|::.:...        ||:|.|        :.|||:...:::::.|...||...:|
  Rat   784 ERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKMQLCELNKKCGEGQEKIRALM-- 846

  Fly   541 DSEQES-KRQLSSLSPPYNPHPRA---------------------------ESAQLREDKESVNS 577
             ||..| |:.|||...|...|...                           |.::|||:.| |..
  Rat   847 -SENTSLKKTLSSQYVPAKTHEEVKASLSSTLEKTNRALLDSKKRLDDTSQEFSKLREENE-VLR 909

  Fly   578 PNFDEYANVIRR-YPNSSETSNPSQNSNSWDWEASPTGSNPHPDYN------------------- 622
            .|.:...|.::. |.:..|.|.....:|....||....:....||.
  Rat   910 RNLENVQNQMKADYVSLEEHSRKMNMANQSLKEAQDAHTALLADYRQGQEEIVTLHAEIKAQKKE 974

  Fly   623 ----------KY--YQRIGRGENMLNSVIKALRKDAS--------------------------FA 649
                      ||  ..|:...|....:..|||::..|                          .|
  Rat   975 LDTIQECIKLKYAPLSRMEECERKFKATEKALKEQLSEQTHKGQVRDEEVKKGKQENERLRKDLA 1039

  Fly   650 DLGKE--------------ETAVNETAEGMG----------------GDKLLYK--EQASEAAGI 682
            .|.||              |.|::...|.:|                .:||:.:  :|.||....
  Rat  1040 ALQKELKDRNVLVEEAREAERALSRKTEELGKQLKELSQKYSDVKSEREKLVEEKAKQTSEILAA 1104

  Fly   683 SNLMKRQPLCLEDNYPVMSNLFYSNPIMEYAEETEVRQNGNESMSKVEIRNSEIKCLKKPNAGQV 747
            .||:::||:.||.                 .|..:...||.....|.|:|:.| :||::.
  Rat  1105 QNLLQKQPVPLEQ-----------------VEALKTSLNGTIEHLKEELRSKE-RCLERE----- 1146

  Fly   748 RDMVAQLQNTIDSNRQDSQT 767
            :..|:|||..:::.:..|.|
  Rat  1147 QQAVSQLQQLLENQKSSSVT 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgo	NP_610614.1	ANK	22..184	CDD:238125	37/198 (19%)
		ANK repeat	24..55	CDD:293786	7/34 (21%)
		Ank_2	29..161	CDD:289560	30/164 (18%)
		ANK repeat	59..128	CDD:293786	8/68 (12%)
		ANK	126..249	CDD:238125	38/156 (24%)
		ANK repeat	130..161	CDD:293786	15/63 (24%)
		Ank_2	135..227	CDD:289560	30/124 (24%)
		ANK repeat	163..194	CDD:293786	8/30 (27%)
		ANK repeat	196..227	CDD:293786	9/30 (30%)
Uaca	NP_001182493.1	ANK	40..155	CDD:238125	26/153 (17%)
		Ank_2	40..127	CDD:289560	24/125 (19%)
		ANK repeat	40..67	CDD:293786	6/26 (23%)
		ANK repeat	69..100	CDD:293786	8/69 (12%)
		ANK	99..222	CDD:238125	29/122 (24%)
		ANK repeat	103..133	CDD:293786	9/29 (31%)
		Ank_2	107..199	CDD:289560	21/91 (23%)
		ANK repeat	136..166	CDD:293786	6/29 (21%)
		ANK repeat	168..199	CDD:293786	8/30 (27%)
		Ank_2	173..254	CDD:289560	20/81 (25%)
		ANK repeat	201..232	CDD:293786	9/30 (30%)
		SCP-1	534..1218	CDD:114219	106/660 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	93	1.000	Inparanoid score	I4984
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050