DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dgo and ANKRD18A

DIOPT Version :9

Sequence 1:	NP_610614.1	Gene:	dgo / 36139	FlyBaseID:	FBgn0086898	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_024303251.1	Gene:	ANKRD18A / 253650	HGNCID:	23643	Length:	1170	Species:	Homo sapiens

Alignment Length:	1121	Identity:	211/1121 - (18%)
Similarity:	374/1121 - (33%)	Gaps:	347/1121 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SGP--DSSNW--TSLHEAVAAGDDRRVEGLL---FSNADRLARESVQGNTPLHEAASRG------ 70
            :||  |..:|  ..:|.|...||...||..|   |.:.|...|:.   .|.||.|.:.|
Human    24 AGPGYDIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKD---RTVLHLACAHGRVQVVT 85

  Fly    71 ---FSRCVKLICTPPTPPASSGVGKAAKGQKDKDKDKNKGRVKVAHQTIEALHNSALGIANNE-- 130
               ..||...||                     |:......:|..|...||.....|....|.
Human    86 LLLHRRCQIDIC---------------------DRLNRTPLMKAVHSQEEACAIVLLECGANPNI 129

  Fly   131 ----GLSALHLAAQNGHNQSSRELLLAGADPDVRNNYGDTPLHTACRYGHAGVSRILLSALCDPN 191
                |.:|||.|..|.....:..||...|:.:..|..|:|||..|.......:...||.     |
Human   130 EDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLK-----N 189

  Fly   192 KTNLNG-----DTALHITCAMGRRKLTRILLEADARLGIKNAQGDCPMHIAIRKNYR----EIIE 247
            :.|::.     .|||.:........:..:||:.:.|:..::..|......|:..:.|    :|:|
Human   190 QANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILE 254

  Fly   248 ILN-----------------TPKKIRNRKEKPK-EGGSRSDKDRDRERDVVDKGINWSP------ 288
            ..|                 .|..::.|||:.| |...:...:..:||  :.:..|..|
Human   255 HKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQER--LQRSENKQPQDSQSY 317

  Fly   289 -------YGCHYFPDPRAFPSPKLETLPKEPLKSGEQYFLDLAGHIHKGPVSVGNTCYCGPFFRH 346
                   ||........|....:|..:..:.|:..::|..::     |....:.         .:
Human   318 GKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEI-----KSITEIN---------AN 368

  Fly   347 IENKLNCNRKSLKKYVHKTKERLGHKVQALAIKTNDQIEQLTRTMIEDRLRCESKRQHLS----- 406
            .|..:..|.|.:.|.|.:..::| :.::|...:.|.::|:....  ::||..|.:..|.|
Human   369 FEKSVRLNEKMITKTVARYSQQL-NDLKAENARLNSELEKEKHN--KERLEAEVESLHSSLATAI 430

  Fly   407 ----EFLRRGEPMRSTFDQQNKSSRIERTMSRCRSL----ELL-ENNHEG--------GRLTNSR 454
                |.:.| :.:.....:.:..||.|:..|....|    ||| |..|:.        |:|..:|
Human   431 NEYNEIVER-KDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETR 494

  Fly   455 SVDVLEDQA---------VEAIVHRSAEVQVDSDSDDDSNEARDEEEAEVGDKDQVQEEAEPEEH 510
              |.|.::.         :....||..|::    ....:.||:  |...:|.::.::|....:|
Human   495 --DALREKTLALGSVQLDLRQAQHRIKEMK----QMHPNGEAK--ESQSIGKQNSLEERIRQQE- 550

  Fly   511 SKLDELKL-----DFLKVSERLGVLLEKTTLIMERDSEQESKRQL-----SSLSPPYNPHPRAES 565
              |:.|.|     |..|..:...:::.     :.||..:..|..|     ..|...|| :.:.:.
Human   551 --LENLLLERQLEDARKEGDNKEIVIN-----IHRDCLENGKEDLLEERNKELMKEYN-YLKEKL 607

  Fly   566 AQLREDK---ESVNSPNFDEYANVIRRYPNSSE----TSNPSQNSN-SW-------DWEASPTGS 615
            .|..::|   |.:.....:|..:.::.:..|..    ||:...|.| :|       ..|..|  .
Human   608 LQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQP--E 670

  Fly   616 NPHPDYNKYYQRIG---------RGE-------------------NMLNS--------------- 637
            ..|.::.|.::.|.         |.:                   ||||:
Human   671 EKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTD 735

  Fly   638 ------VIKALRKDASFADLGKEETAVN------------------------ETAEGMGGDKLL- 671
                  :.|.|::  .|.||..|:.||:                        |..|.:..||.:
Human   736 QLKMDILFKKLKQ--KFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKML 798

  Fly   672 -----------------------YKEQASEAAGISNLMKRQPLCLEDNYPVMSNLFYSNPIMEYA 713
                                   ||.:..|.| :..:.|.:.:.|:..             .||.
Human   799 EEEVLNLKTHMEKDMVELGKLQEYKSELDERA-VQEIEKLEEIHLQKQ-------------AEYE 849

  Fly   714 EETE-VRQNGNESMSKVEIRNSEIKC------------------LKKPNAGQVRDMVAQLQNTID 759
            ::.| :.::...|:.|.|:...:::|                  .|:..||.|:     ..|::.
Human   850 KQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVK-----ANNSMS 909

  Fly   760 SN--RQDSQTAHVIAARSHSRLNNNFHHLEGTSSNPSPTY-SIPHRSSAQFGLPERHIPKDAYFH 821
            ..  :.|.:.| ||:.:..:......:.|....:.|.|.. .:.:.:|.:  |..::|||.|.
Human   910 KKLMKSDKKIA-VISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLNSIE--LNRKYIPKTAI-- 969

  Fly   822 ELPHRPPI--PQTPQRRLHSGYVPNASLYRSEDLYVG---RIPHPNAPPRQVDYVDAVAYRPLQS 881
                |.|.  |||...  ...::....|.|.|.:..|   .....:...|.:.:|::.|.|..:.
Human   970 ----RIPTSNPQTSNN--CKNFLTEMELDRVEQIITGTKKSFAMLSTCSRLLSFVESTAPRKHRR 1028

  Fly   882 --PTFQAIVPPHVNQR 895
              |..:::||   |:|
Human  1029 ALPIMRSLVP---NRR 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgo	NP_610614.1	ANK	22..184	CDD:238125	43/181 (24%)
		ANK repeat	24..55	CDD:293786	10/35 (29%)
		Ank_2	29..161	CDD:289560	35/149 (23%)
		ANK repeat	59..128	CDD:293786	15/77 (19%)
		ANK	126..249	CDD:238125	31/137 (23%)
		ANK repeat	130..161	CDD:293786	9/36 (25%)
		Ank_2	135..227	CDD:289560	23/96 (24%)
		ANK repeat	163..194	CDD:293786	8/30 (27%)
		ANK repeat	196..227	CDD:293786	6/35 (17%)
ANKRD18A	XP_024303251.1	Ank_4	34..88	CDD:316185	15/56 (27%)
		ANK repeat	38..65	CDD:293786	9/26 (35%)
		ANK	62..187	CDD:238125	33/148 (22%)
		ANK repeat	69..98	CDD:293786	9/49 (18%)
		ANK repeat	100..131	CDD:293786	6/30 (20%)
		ANK	128..253	CDD:238125	28/129 (22%)
		ANK repeat	133..164	CDD:293786	9/30 (30%)
		ANK repeat	166..197	CDD:293786	9/35 (26%)
		ANK repeat	199..230	CDD:293786	6/30 (20%)
		CCDC144C	327..617	CDD:317340	59/324 (18%)
		SMC_N	<460..907	CDD:330553	82/486 (17%)
		DUF3496	865..969	CDD:314818	20/111 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I5159
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050