DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dgo and ANKRD6

DIOPT Version :9

Sequence 1:	NP_610614.1	Gene:	dgo / 36139	FlyBaseID:	FBgn0086898	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	XP_005248736.1	Gene:	ANKRD6 / 22881	HGNCID:	17280	Length:	752	Species:	Homo sapiens

Alignment Length:	719	Identity:	163/719 - (22%)
Similarity:	255/719 - (35%)	Gaps:	237/719 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TSLHEAVAAGDDRRVEGLLFSNADRLARESVQGNTPLHEAASRGFSRCVKLICTPPTPPASSGVG 91
            |:||.|...|:...:..|:.... .|.|:...|||.||||:..|||:..||:       ..:|..
Human   102 TALHRATVVGNTEIIAALIHEGC-ALDRQDKDGNTALHEASWHGFSQSAKLL-------IKAGAN 158

  Fly    92 KAAKGQKDKDKDKNKGRVKVAHQTIEALHNSALGIANNEGLSALHLAAQNGHNQSSRELLLAGAD 156
            ..||                                |..|.:|||||.||.|:||:|.|||||:.
Human   159 VLAK--------------------------------NKAGNTALHLACQNSHSQSTRVLLLAGSR 191

  Fly   157 PDVRNNYGDTPLHTACRYGHAGVSRILLSALCDPNKTNLNGDTALHITCAMGRRKLTRILLEADA 221
            .|::||.|||.||.|.||.|..:.|:||:|.|..::.|..||||||:..|:..:|:.:|||||.|
Human   192 ADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGA 256

  Fly   222 RLGIKNAQGDCPMHIAIRKNYREIIEIL---------NTPKKIRNRKEKPKEGGSRSDKDRD--- 274
            ...|.|..|..|:..|...|..|:..:|         :..:.:|.::|:.||........||
Human   257 DTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVA 321

  Fly   275 -------------------RERDVVDKGINWSPYGCHYFPDPRAFPSPKLETLPK-----EPLKS 315
                               |:.:..::.::.|       |:|||....:.::.||     :|...
Human   322 QSKGSVSAGDTPSSEQAVARKEEAREEFLSAS-------PEPRAKDDRRRKSRPKVSAFSDPTPP 379

  Fly   316 GEQ---YFLDLAGHIH-----------------------------------KGPVSVGNTCYCGP 342
            .:|   :..:|..|.|                                   :.|:   |.|.|.|
Human   380 ADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPI---NGCRCEP 441

  Fly   343 FFRHIENKLNCNRKSLKKYVHKTKERLGHKVQALAIKTNDQIEQLTRTMIE----DRLRCESK-R 402
            ....:||:|....:.:|..:...::::..|:..:..||..|:..|.:.|:|    :|..|.:: :
Human   442 LINKLENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRLQ 506

  Fly   403 QHLSEFLRRGEPMR-STFDQ---------QN---------KSSRIERTMSRCRS----------- 437
            ||.......||..: |..|:         ||         ::.|.:.|.|.|.|
Human   507 QHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVDQLVVTA 571

  Fly   438 -----------------------------LELLENNHEGGRLTNSRSVDVL--------EDQAVE 465
                                         .||..::..|.||.|.:....|        .||...
Human   572 GPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAG 636

  Fly   466 AIVHRSAEVQVDSDSDDDSNEAR-----------------DEEEAEVGDKDQVQE------EAEP 507
            ..|:|..:.:....|....:.|:                 ::....:.|..|..|      ||..
Human   637 PCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVS 701

  Fly   508 EEHSKLDELKLDFLKVSERLGVLLEKTTLIMERDSEQESKRQLSSLSPPYNPHPRAESAQLREDK 572
            .:..|..|.|::..:.........:|.||          |..:.||        ..|.|:||...
Human   702 TQMEKWYERKIEEARSQANQKAQQDKATL----------KEHIKSL--------EEELAKLRTRV 748

  Fly   573 ESVN 576
            :..|
Human   749 QKEN 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgo	NP_610614.1	ANK	22..184	CDD:238125	54/156 (35%)
		ANK repeat	24..55	CDD:293786	7/27 (26%)
		Ank_2	29..161	CDD:289560	41/131 (31%)
		ANK repeat	59..128	CDD:293786	15/68 (22%)
		ANK	126..249	CDD:238125	57/122 (47%)
		ANK repeat	130..161	CDD:293786	18/30 (60%)
		Ank_2	135..227	CDD:289560	48/91 (53%)
		ANK repeat	163..194	CDD:293786	14/30 (47%)
		ANK repeat	196..227	CDD:293786	15/30 (50%)
ANKRD6	XP_005248736.1	ANK repeat	101..130	CDD:293786	8/28 (29%)
		Ank_2	104..196	CDD:289560	41/131 (31%)
		ANK	127..252	CDD:238125	61/163 (37%)
		ANK repeat	132..163	CDD:293786	15/69 (22%)
		ANK repeat	166..196	CDD:293786	18/29 (62%)
		Ank_2	170..262	CDD:289560	48/91 (53%)
		ANK repeat	198..229	CDD:293786	14/30 (47%)
		ANK repeat	231..262	CDD:293786	15/30 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152701
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BHC7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_111903
Panther	1	1.100	-	-	LDO	PTHR24203
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10493
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.860