DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dgo and Ankrd35

DIOPT Version :9

Sequence 1:	NP_610614.1	Gene:	dgo / 36139	FlyBaseID:	FBgn0086898	Length:	927	Species:	Drosophila melanogaster
Sequence 2:	NP_001074608.1	Gene:	Ankrd35 / 213121	MGIID:	2442590	Length:	996	Species:	Mus musculus

Alignment Length:	891	Identity:	170/891 - (19%)
Similarity:	308/891 - (34%)	Gaps:	267/891 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LHEAVAAGDDRRVEGLLFSNADRLARESVQGNTPLHEAASRGFSRCVKLICTPPTPPASSGVGKA 93
            |.|||..||..||..|....:.|..:....|.:|.|.|||:|.:.|:.::       .::|....
Mouse    24 LLEAVQRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTIL-------LANGADIN 81

  Fly    94 AKGQKDKDKDKNKGRVKVAHQTIEAL--HNSALGIANNEGLSALHLAAQNGHNQSSRELLLAGAD 156
            :|.: |.....:...:....|.::.|  |.:.....:.|..|.||.||.:|  .:|..|||...:
Mouse    82 SKNE-DGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSG--CASSVLLLCDHE 143

  Fly   157 P--DVRNNYGDTPLHTACRYGHAGVSRILLSALCDPNKTNLNGDTALHITCAMGRRKLTRILLEA 219
            .  ||.:|.|.|||..|...|||.:...||......|.|:.:..:||.:.|..|..::..:||..
Mouse   144 AFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKDDKSALILACEKGSAEVAELLLSH 208

  Fly   220 DARLGIKNAQGDCPMHIAIRKNYREIIEILNTPKKIRNRKEKPKEGGSRSDKDRDRERDVVDKGI 284
            .|..|..::.|...:|.|:|...:|:..:|   ::..||:   :.||
Mouse   209 GADAGAVDSLGHNALHYALRTQDKELWRLL---QQALNRR---RRGG------------------ 249

  Fly   285 NWSPYGCHYFPDPRAFPS------PKLETLPK-----EPLKSGEQYFLDLAGHIHKGPVSVGNTC 338
                :|....||   .||      |::.:.||     ||.:..|:
Mouse   250 ----HGLVQHPD---HPSQASSCEPRVGSPPKNSRKVEPEEEQEE-------------------- 287

  Fly   339 YCGPFFRHIENKLNCNRKSLKKYVHKTKERLGHKVQALAIKTNDQIE--QLTRTMIEDRLRCESK 401
                     |.:..|:.:...|:  :.::|..|:::...::..|:.:  ....:.:|:::|  .:
Mouse   288 ---------EGEERCSEEWRWKF--EEEQRKVHQLEQELVRKTDECKAHAAAFSSLEEQIR--EQ 339

  Fly   402 RQHLSEFL--------RRGEPMRSTFD--------------------QQNKSSRIERTM--SRCR 436
            .|.|...|        .:|..:|...|                    ||...:.|..|:  .|..
Mouse   340 AQELGHLLVQEPGAPGNQGPGLRPEGDGMEEGCPLNLLAERIQELKKQQKALATINPTLVPKRAE 404

  Fly   437 SLELLENNHEGGRLTNSRSVDVLEDQAVEAIVHRSAEVQ---VDSDSDDDSNEARDEEEAEVG-- 496
            .|...|.:||                     |||.::.:   ....|.:.:.:|..::....|
Mouse   405 ELAPAEIHHE---------------------VHRKSQPEQGLPQGPSSETTGKATGQQPNTNGGQ 448

  Fly   497 -----DKDQV---QEEAEPEEHSKLDELKLDFLKVSERLGVLLEKTTLIMERD-----SEQESKR 548
                 :.:||   |:|..|...::...      .|.|.:|:.:.:..|.:..:     .|:::.|
Mouse   449 NLGLQNTEQVCAGQKERTPAPGTETAG------TVGEPVGIAMNQLLLQLREELAAVWREKDAAR 507

  Fly   549 QLSSLSPPYNP----HPRAESAQLREDKESVNSPNFDEYANVIRRYPNSS-----ETSNPSQNSN 604
              .:||.|...    .||||:|....:|...      ....|:.|...:.     :...|.|.|.
Mouse   508 --GALSRPVLEGALGTPRAEAAAAAWEKMEA------RLERVLVRLDGAKMGLHVKPEVPVQGSR 564

  Fly   605 SWDWEASPTGSNPHPDYNKYY-------------QRIGRG--ENMLNSVIKALRKDAS-----FA 649
            ....:|.| |.:...:..|..             |.:|.|  :..|...:.|||...|     ..
Mouse   565 DGAPKAVP-GCSKEQEEKKALGTRGEPLGAPGKEQALGGGLAKGQLEKEVSALRLSNSNLLEELG 628

  Fly   650 DLGKEETAVN---------------------------ETAEGMGGDKLLYKEQ---------ASE 678
            :||:|...:.                           ..:.||..::|..:::         ||:
Mouse   629 ELGRERQRLQGELQSLTQRLHREFVPKPEAQVQLQQLRRSVGMLTEELAMEKEATDKLRRLLASQ 693

  Fly   679 AAGISNLMK----------------RQPLCLEDNYPVMSNL----FYSNPIMEYAEETEVRQNGN 723
            .:|:..|.|                .:|  ||:....:|.|    ..:..::...||...:..|:
Mouse   694 TSGLQGLWKCLPPDLVGKGNTQSTAAEP--LEELQACISTLVDRHLEAQRVLARLEEENQQLRGS 756

  Fly   724 -----ESMSKVEIRNSEIKCLKKPNAGQVRDMVAQLQNTIDSNRQD 764
                 |..:.:::..|......:.:.|.:.:.:..:|.|:....|:
Mouse   757 LAPCGEPEASLKVTASPQVAALEEDLGMLEEELRAVQATMSGKSQE 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgo	NP_610614.1	ANK	22..184	CDD:238125	46/158 (29%)
		ANK repeat	24..55	CDD:293786	10/25 (40%)
		Ank_2	29..161	CDD:289560	37/135 (27%)
		ANK repeat	59..128	CDD:293786	14/70 (20%)
		ANK	126..249	CDD:238125	39/124 (31%)
		ANK repeat	130..161	CDD:293786	13/32 (41%)
		Ank_2	135..227	CDD:289560	32/93 (34%)
		ANK repeat	163..194	CDD:293786	11/30 (37%)
		ANK repeat	196..227	CDD:293786	8/30 (27%)
Ankrd35	NP_001074608.1	ANK	<24..107	CDD:238125	22/90 (24%)
		ANK repeat	24..51	CDD:293786	10/26 (38%)
		ANK repeat	53..84	CDD:293786	9/37 (24%)
		ANK	81..206	CDD:238125	35/127 (28%)
		ANK repeat	86..117	CDD:293786	4/30 (13%)
		ANK repeat	119..150	CDD:293786	13/32 (41%)
		ANK repeat	152..183	CDD:293786	11/30 (37%)
		ANK repeat	185..216	CDD:293786	8/30 (27%)
		Ank_2	190..>251	CDD:315466	17/88 (19%)
		SMC_N	<710..>996	CDD:330553	14/95 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I5009
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.050