DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7222 and DESI2

DIOPT Version :9

Sequence 1:	NP_001286295.1	Gene:	CG7222 / 36138	FlyBaseID:	FBgn0033551	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	XP_011542505.1	Gene:	DESI2 / 51029	HGNCID:	24264	Length:	211	Species:	Homo sapiens

Alignment Length:	172	Identity:	99/172 - (57%)
Similarity:	138/172 - (80%)	Gaps:	10/172 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VILNVYDM-----YWINEYTTSIGLGVFHSGVEAFGTEFAYGGHPFPFTGVFEISPRDHDELGDQ 98
            |:|..|.:     ||:||||:|||:||||||:|.:|.||||||||:||:|:|||||.:..|||:.
Human    19 VVLLSYTLKTTFQYWMNEYTSSIGIGVFHSGIEVYGREFAYGGHPYPFSGIFEISPGNASELGET 83

  Fly    99 FQFRQSIQIGCTDFTYEEVRRIVEELGNQFRGDRYHLMNNNCNHFSGSLTQILCGQEIPSWVNRL 163
            |:|::::.:|.|||..:::.:||||||.:::|:.||||:.||||||.:|::||||:|||.|:|||
Human    84 FKFKEAVVLGSTDFLEDDIEKIVEELGKEYKGNAYHLMHKNCNHFSSALSEILCGKEIPRWINRL 148

  Fly   164 AHFSSCVPFLQRCLPKEWLTPNALQQSIT-----TIQEREDS 200
            |:||||:||||.|||||||||.|||.|::     .::|.||:
Human   149 AYFSSCIPFLQSCLPKEWLTPAALQSSVSQELQDELEEAEDA 190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7222	NP_001286295.1	Peptidase_C97	37..181	CDD:399119	87/146 (60%)
DESI2	XP_011542505.1	Peptidase_C97	37..166	CDD:368660	80/128 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159685
Domainoid	1	1.000	225	1.000	Domainoid score	I2534
eggNOG	1	0.900	-	-		E1_KOG0324
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56741
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3251
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59072
OrthoDB	1	1.010	-	-		D1300278at2759
OrthoFinder	1	1.000	-	-		FOG0001883
OrthoInspector	1	1.000	-	-		oto91484
orthoMCL	1	0.900	-	-		OOG6_101256
Panther	1	1.100	-	-	LDO	PTHR12378
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R546
SonicParanoid	1	1.000	-	-		X1415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800