Protein Alignment Amfr and hrdl-1

DIOPT Version :9

• Sequence 1: XP_038954087.1
• Gene: Amfr / 361367
• RGDID: 1311551
• Length: 643
• Species: Rattus norvegicus
• Sequence 2: NP_492602.2
• Gene: hrdl-1 / 172833
• WormBaseID: WBGene00009164
• Length: 579
• Species: Caenorhabditis elegans
• Alignment Length: 638
• Identity: 149/638 - (23%)
• Similarity: 270/638 - (42%)
• Gaps: 122/638 - (19%)

  Rat     6 LERFPWPSLRTYTGLSGLALLGTIVSAYRAL-SQPEDGSGEPEPLTAPLQPEALAPARLTP---- 65
            |.|..:||:.:|..||.|..:...|:.:... ||||        |...::.|.....||:.
 Worm    22 LSRSSFPSVDSYLALSVLVAIVASVTVFTTFRSQPE--------LQKLIEEELRNNTRLSSAYGL 78

  Rat    66 -----GGPRVRDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNF 125
                 .|.....:|.|:|||:..:||.:|:...:|.:..:||..:.|..|...|....:..|:.:
 Worm    79 NIEALSGHTFFQIAHYILSDTTLIWVAINSYFAILAVCTRLIIKLTFKELARQEENVARQAFFCY 143

  Rat   126 IFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFL-HLMVQLCKDRFEYLSFSPTTPMSSHGRVLSL 189
            :....:::..|:..|....|:.|.:|.....|| ||....|: |.:::|     |....|.....
 Worm   144 VLLTIVYLSVVIGPQKGHRVMPWMIWGGICAFLSHLQFITCQ-RLKHIS-----PSCDRGSQKIS 202

  Rat   190 LIAMLLSCCGLAVVCCVTGYTHGM--HTLAFMAAESLLVTVRTAHVILRYV--IHLWDLN----- 245
            .:::.|....:|:...::.:.|.:  .....:..:.||...|:.:::.|.:  ..::..|
 Worm   203 FLSLFLFFVSIAMTFLISRFQHHLTWQPAVLLYFDCLLAVFRSTYILFRCISSSRVFSFNPDSVR 267

  Rat   246 HEGTWEGKGTYVYYTDFVMELMLLSLDLMHHIHMLLFGNI-----WLSMASLVIFMQLRYLFHEV 305
            |...|     ....|:||.||          |.||.|..:     .|::.|:.....::..::.:
 Worm   268 HFNYW-----LELITNFVCEL----------IQMLSFAQLLAFSPGLNLTSIFFLYHMKLTYNCM 317

  Rat   306 QRRIRRHKNYLRVVGNMEARFAVATAEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCLRSWLE 370
            ..::.||:|:.::..::|..:   .:.:.|..:|.|.:||:.:..:|:|||.|.||:.||..||.
 Worm   318 TEQLSRHRNHKKIFEHIERSY---PSVKCANGDDRCVVCWELLGTSRRLPCSHQFHDWCLMWWLA 379

  Rat   371 QDTSCPTCRMSLNIADGSRAREDHQGENLDENLVPVAAAEGRPRLNQHNH-FFHFDGSRIASWLP 434
            ||:||||||.::. :...:.|:.           |......|.|.|..:. |.||         |
 Worm   380 QDSSCPTCRCTIP-SPQDQIRQP-----------PEVGNSTRLRFNGGSFGFVHF---------P 423

  Rat   435 SFSVEVMHTTN-ILG-ITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQMTRSVEITTDNILEGR 497
            :|::||..... ..| ..:.:..||..|..|::|||||:...:::.||:.:.|.:.|.:||||||
 Worm   424 AFTLEVAANFGPFFGRAAEPTEEQLQTMLEQVREMFPQMSVDIIMTDLRQSGSAQSTIENILEGR 488

  Rat   498 IQVPFPVQRSDSLRPALNSPVERPGTDLEEGEASVQTERVPLDLSPRLEETLDFSEVELEPVEVE 562
            |              .:|:.. .||..|::            :||...|..:::.    ||.|:.
 Worm   489 I--------------GMNASF-MPGGVLDD------------ELSDESENEIEYE----EPAEIV 522

  Rat   563 DFEARGSR------FSKSADERQRMLVQRKDDLLQQARKRFLNKSSEDDGASE 609
            .....|.:      .|.|.||.......::..:::..|:::|    |.|.|::
 Worm   523 QEPDNGRQRTWTKLSSSSGDEDLSYYEIQRAKMIETYRRKYL----ESDKAAD 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Amfr	XP_038954087.1	HRD1	86..>382	CDD:227568	72/310 (23%)
		RING-H2_AMFR	339..382	CDD:319369	23/42 (55%)
		CUE_AMFR	458..498	CDD:270604	16/39 (41%)
		G2BR	575..600	CDD:375868	4/24 (17%)
hrdl-1	NP_492602.2	HRD1	<200..>407	CDD:227568	51/236 (22%)
		zf-RING_2	348..388	CDD:290367	21/39 (54%)
		CUE_AMFR	449..489	CDD:270604	16/39 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C162963747
Domainoid	1	1.000	63	1.000	Domainoid score	I7303
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H888
Inparanoid	1	1.050	153	1.000	Inparanoid score	I3321
OMA	1	1.010	-	-		QHG55068
OrthoDB	1	1.010	-	-		D271732at33208
OrthoFinder	1	1.000	-	-		FOG0006872
OrthoInspector	1	1.000	-	-		oto28100
orthoMCL	1	0.900	-	-		OOG6_105132
Panther	1	1.100	-	-	LDO	PTHR15067
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3836
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910