Protein Alignment mms4 and eme2

DIOPT Version :10

• Sequence 1: NP_610611.1
• Gene: mms4 / 36136
• FlyBaseID: FBgn0033549
• Length: 309
• Species: Drosophila melanogaster
• Sequence 2: NP_001072860.1
• Gene: eme2 / 780321
• XenbaseID: XB-GENE-5926460
• Length: 503
• Species: Xenopus tropicalis
• Alignment Length: 387
• Identity: 82/387 - (21%)
• Similarity: 150/387 - (38%)
• Gaps: 99/387 - (25%)

  Fly     4 KVDKLHKQALREQQ---KRIKPGECMKYVRMVIDAGFLGIPVGQEALQQLNATGLKYEIRSLPVS 65
            :::|:.::..:|..   |.::|.:|.||:.:.:|||.|.....::.|:.|......|.|....|.
 Frog   131 ELEKIERERRKETNLALKLLRPDQCGKYMVVKVDAGLLEDAGSEDVLEALRVAEYNYSIEPHSVP 195

  Fly    66 HCILWERNVGQQTIALGSSPTGLDEAWKSENQVVQWLSESSFQRAVKDQS----LVCLGPRLQD- 125
            ..|.|.|.:......:    .|:|...:.|:|::..:...|:..:|:..:    ..|:|..:::
 Frog   196 QSISWRREMPADWTCI----EGMDMKEEEEDQLLVLVEPKSYLSSVRTYAQAPYYFCVGNEMEEI 256

  Fly   126 ---------SFPDCQYTIALPTL-----------------------RHSKHGSSSS-------QD 151
                     ..|..:.|:.:..|                       |.|....|::       |:
 Frog   257 PGSVFSIPAKNPHKKVTLVIIGLQEYRWCERLSRQIQRQSLDAAEGRDSNKDQSATRATRQQIQE 321

  Fly   152 ALIEMQLLQELHVEQLD--QPESQDLVALLQRYTKAIAEAPYKKQRNETLGGFKKYLANDKKQCV 214
            ||:.:||.....|..||  :...|.:.|:    ||:||:.|::|........|          |.
 Frog   322 ALVFLQLHYNTEVLCLDTWKELGQHVCAV----TKSIAQRPFRKHWEAQTFSF----------CT 372

  Fly   215 RVDQGNGYG---------RLWQQHLNRLPMVTLEVAESIIAQYPCPKKLIDHFS---SDPLAVQS 267
            ......|:|         ..|::.:.:|..|:..:|..:...||.|:.|:..:|   ||...:..
 Frog   373 SAGSWRGWGPRGVLTGLPLTWRRQIQQLNRVSPAMAAVVSQAYPSPQLLMQAYSACGSDRERMSL 437

  Fly   268 LADLKIKRCN--------------------GPQPLHTERRIGNVLSNKLYTLYTAKDPNTLI 309
            |.||:|.:.|                    |.|....|||||..||.:::.|.|:|:|..::
 Frog   438 LTDLRIPQDNNTGVTQKAEDPREVADIAQEGDQVPGRERRIGPDLSRRIWLLMTSKNPELVL 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mms4	NP_610611.1	XPF_nuclease_EME	28..192	CDD:410859	42/209 (20%)
eme2	NP_001072860.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..135		0/3 (0%)
		Nuclease-like domain, forms the post-nick DNA binding interface and is involved in DNA recognition and bending. /evidence=ECO:0000250|UniProtKB:A4GXA9	70..366		49/242 (20%)
		Uup	<106..>160	CDD:440254	7/28 (25%)
		XPF_nuclease_EME2	151..360	CDD:410858	45/216 (21%)
		Helix-hairpin-helix (2HhH), forms the pre-nick DNA binding interface and is involved in DNA recognition and bending. /evidence=ECO:0000250|UniProtKB:A4GXA9	388..503		29/112 (26%)