DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mms4 and Eme1

DIOPT Version :9

Sequence 1:	NP_610611.1	Gene:	mms4 / 36136	FlyBaseID:	FBgn0033549	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	NP_001366617.1	Gene:	Eme1 / 268465	MGIID:	3576783	Length:	589	Species:	Mus musculus

Alignment Length:	368	Identity:	93/368 - (25%)
Similarity:	155/368 - (42%)	Gaps:	89/368 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EQQKRIK---PGECMKYVRMVIDAGFLGIPVGQEALQQLNA--TGLKYEIRSLPVSHCILWERN- 73
            |..||:|   |.||:|::.:|:|...|.:..|.:.|..|.|  .....|::::|.|  |.|.|.
Mouse   234 EMIKRLKAQRPEECLKHIVVVLDPVLLQMEGGGQLLGALQAMECSCVIEVQAIPRS--ITWRRRR 296

  Fly    74 -------VGQQTIALGSSP------TGLDEAWKSENQV---------------VQWLSESSFQRA 110
                   |.::. |.||.|      .|.|  |..|..:               ::..|.||.::.
Mouse   297 TELVELPVAERG-ATGSIPFPCLNEDGDD--WMEEPTILVLVLAEVFMSMAYNLKQASPSSTEKG 358

  Fly   111 V---------------KDQSLV------CLGP-----RLQDSFPDCQYTIALPTLRHSKHGSSSS 149
            .               |..|||      |..|     |.:....:.|     ...:|.:...||:
Mouse   359 KETLRSFVTDVTAKTGKALSLVIVDQEKCFRPQNPPRRRKSGMANKQ-----AKAKHQQRQESST 418

  Fly   150 ---------QDALIEMQLLQELHVEQLDQPESQDLVALLQRYTKAIAEAPYKKQRNETLGGFKKY 205
                     :.||:::||..|.....:.  ..::|......:|||:||||:||.|::..  |..:
Mouse   419 GLMVSRADMEKALVDLQLYTEAQAWMVQ--SWKELADFTCAFTKAVAEAPFKKLRDQVT--FSFF 479

  Fly   206 LANDKKQCVRVDQ-GNGYGRLWQQHLNRLPMVTLEVAESIIAQYPCPKKLIDHFS---SDPLAVQ 266
            |..|....::||| |.|...:|::.:.:|..|:.|:|.:|:..||.|:.|:..:.   |:.....
Mouse   480 LEKDWAGGMKVDQSGRGLALIWRRQIQQLNRVSSEMASAIVDAYPSPQLLVQAYQRCFSEQERQN 544

  Fly   267 SLADLKIKRCNGPQPLHTERRIGNVLSNKLYTLYTAKDPNTLI 309
            .|||::::|..|...  |.||:|..||.::|...|...|:.::
Mouse   545 LLADIQVRRGEGVTA--TSRRVGPELSRRIYLQMTTAQPDLIL 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mms4	NP_610611.1	ERCC4	48..179	CDD:280828	37/196 (19%)
Eme1	NP_001366617.1	XPF_nuclease_EME1	243..471	CDD:410857	55/239 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836854
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CRM8
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H16123
Inparanoid	1	1.050	79	1.000	Inparanoid score	I5207
Isobase	1	0.950	-	0	Normalized mean entropy	S6738
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004634
OrthoInspector	1	1.000	-	-		otm42493
orthoMCL	1	0.900	-	-		OOG6_105221
Panther	1	1.100	-	-	O	PTHR21077
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4863
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.730