DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mms4 and EME2

DIOPT Version :9

Sequence 1:	NP_610611.1	Gene:	mms4 / 36136	FlyBaseID:	FBgn0033549	Length:	309	Species:	Drosophila melanogaster
Sequence 2:	NP_001244299.1	Gene:	EME2 / 197342	HGNCID:	27289	Length:	379	Species:	Homo sapiens

Alignment Length:	349	Identity:	78/349 - (22%)
Similarity:	141/349 - (40%)	Gaps:	79/349 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KQALREQQKRIKPGECMKYVRMVIDAGFL---GIPVGQEALQQLN----------ATGLKYE--- 58
            ::|..|..:.::|.:.:|.:.:.:|...|   |..|..|||:.|.          |..|::.
Human    57 RRAAAEALRLLRPEQVLKRLAVCVDTAILEDAGADVLMEALEALGCECRIEPQRPARSLRWTRAS 121

  Fly    59 ----IRSLPVSHCILWERNVGQQTIALGSSPTGLDEAWKSENQV------VQWLSESSFQRAVKD 113
                .||||..   :|.  .|:|.:.|...|....:...:..|:      |.|:|..:..|
Human   122 PDPCPRSLPPE---VWA--AGEQELLLLLEPEEFLQGVATLTQISGPTHWVPWISPETTAR---- 177

  Fly   114 QSLVCLGPRLQDSFPDCQYTIALPTLRHSKHGSSSS-----------------QDALIEMQLLQE 161
            ..|..:|   .|::        |.:.:|...|:...                 ::||:.:||...
Human   178 PHLAVIG---LDAY--------LWSRQHVSRGTQQPESPKVAGAEVAVSWPEVEEALVLLQLWAN 231

  Fly   162 LHVEQLDQPESQDLVALLQRYTKAIAEAPYKKQRNETLGGF---KKYLANDKKQCVRVDQGNGYG 223
            |.|  |.....|:|...:...|||:|:.|.|:.|......|   .::.|.:.   |..| |.|..
Human   232 LDV--LLVASWQELSRHVCAVTKALAQYPLKQYRESQAFSFCTAGRWAAGEP---VARD-GAGLQ 290

  Fly   224 RLWQQHLNRLPMVTLEVAESIIAQYPCPKKL---IDHFSSDPLAVQSLADLKIKRCNGPQPLHTE 285
            ..|::.:.:...|:..||::::..:|.|:.|   ::..|::...:..||||.:....|.:|
Human   291 AAWRRQIRQFSRVSPAVADAVVTAFPSPRLLQQALEACSTERERMGLLADLPVPPSEGGRP---- 351

  Fly   286 RRIGNVLSNKLYTLYTAKDPNTLI 309
            ||:|..||.::....|..:|:.|:
Human   352 RRVGPDLSRRICLFLTTANPDLLL 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mms4	NP_610611.1	ERCC4	48..179	CDD:280828	32/170 (19%)
EME2	NP_001244299.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
EME2	NP_001244299.1	ERCC4	<177..249	CDD:280828	16/88 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146905
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I5123
Isobase	1	0.950	-	0	Normalized mean entropy	S6738
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1595761at2759
OrthoFinder	1	1.000	-	-		FOG0004634
OrthoInspector	1	1.000	-	-		otm40418
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21077
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.950