DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fech and FeCH

DIOPT Version :9

Sequence 1:	XP_006254912.1	Gene:	Fech / 361338	RGDID:	1307556	Length:	453	Species:	Rattus norvegicus
Sequence 2:	NP_524613.1	Gene:	FeCH / 43757	FlyBaseID:	FBgn0266268	Length:	384	Species:	Drosophila melanogaster

Alignment Length:	354	Identity:	199/354 - (56%)
Similarity:	267/354 - (75%)	Gaps:	0/354 - (0%)

- Green bases have known domain annotations that are detailed below.

  Rat    95 RKPKTGILMLNMGGPETLGEVQDFLQRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGG 159
            :||||.|||||||||....:|.|:|.|:..|||::.||:|::|.|:||:||||::|::|:.||||
  Fly    25 QKPKTAILMLNMGGPTHTDQVHDYLLRIMTDRDMIQLPVQSRLGPWIAQRRTPEVQKKYKEIGGG 89

  Rat   160 SPIKMWTSKQGEGMVKLLDELSPDTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQY 224
            |||..||..||:.|.:.||.:||:|||||:|:|||||:||||..:.|:|:|..||.:.|:|||||
  Fly    90 SPILKWTELQGQLMCEQLDRISPETAPHKHYVGFRYVNPLTENTLAEIEKDKPERVVLFSQYPQY 154

  Rat   225 SCSTTGSSLNAIYRYYNEVGRKPTMKWSTIDRWPTHPLLIQCFADHILKELDHFPEEKRSEVVIL 289
            ||:|:|||.|:|:.:|........:|||.||||.||||||:.||..|..||..|.|.||::||||
  Fly   155 SCATSGSSFNSIFTHYRSNNLPSDIKWSIIDRWGTHPLLIKTFAQRIRDELAKFVETKRNDVVIL 219

  Rat   290 FSAHSLPMSVVNRGDPYPQEVGATVHRVMEQLGYPNPYRLVWQSKVGPVPWLGPQTDEAIKGLCE 354
            |:|||||:..|||||.||.|:||:||.||::||..|||.|.|||||||:|||.|.||:||||..:
  Fly   220 FTAHSLPLKAVNRGDAYPSEIGASVHMVMQELGQTNPYSLAWQSKVGPLPWLAPATDDAIKGYVK 284

  Rat   355 RGRKNILLVPIAFTSDHIETLYELDIEYSQVLAQKCGAENIRRAESLNGNPLFSKALADLVHSHI 419
            :|.||.:||||||.::|||||:||||||...||::.|.|.||||.:.|.:|||..||.::|..|:
  Fly   285 QGLKNFILVPIAFVNEHIETLHELDIEYCDELAKEVGVEEIRRAATPNDHPLFIDALTNVVADHL 349

  Rat   420 QSNKLCSTQLSLSCPLCVNPVCRKTKSFF 448
            :|.:..:.:..:.||:|.||.||::||::
  Fly   350 KSQQAVNPKFLMRCPMCSNPKCRESKSWY 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fech	XP_006254912.1	Ferrochelatase	99..419	CDD:279146	185/319 (58%)
		Ferrochelatase_N	99..260	CDD:239504	88/160 (55%)
		Ferrochelatase_C	265..402	CDD:238240	84/136 (62%)
FeCH	NP_524613.1	Ferrochelatase	29..349	CDD:279146	185/319 (58%)
		Ferrochelatase_N	29..190	CDD:239504	88/160 (55%)
		Ferrochelatase_C	195..332	CDD:238240	84/136 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338119
Domainoid	1	1.000	402	1.000	Domainoid score	I710
eggNOG	1	0.900	-	-		E1_COG0276
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H113
Inparanoid	1	1.050	434	1.000	Inparanoid score	I1647
OMA	1	1.010	-	-		QHG62486
OrthoDB	1	1.010	-	-		D1003638at2759
OrthoFinder	1	1.000	-	-		FOG0004364
OrthoInspector	1	1.000	-	-		oto96974
orthoMCL	1	0.900	-	-		OOG6_101310
Panther	1	1.100	-	-	LDO	PTHR11108
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3086
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770