Protein Alignment wde and ATF7IP

DIOPT Version :10

• Sequence 1: NP_610608.1
• Gene: wde / 36133
• FlyBaseID: FBgn0027499
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: NP_851997.1
• Gene: ATF7IP / 55729
• HGNCID: 20092
• Length: 1278
• Species: Homo sapiens
• Alignment Length: 1496
• Identity: 334/1496 - (22%)
• Similarity: 539/1496 - (36%)
• Gaps: 420/1496 - (28%)

  Fly   107 IDSLDRDEECDSASAKKRTAADTDENLKEQREKPEEE--EEGEEVLSSLEGEECIDPDSELKTEE 169
            :|||:..::  .....::|...:|....|...|.:||  :...::|:.......:||.|.|
Human     9 MDSLEEPQK--KVFKARKTMRVSDRQQLEAVYKVKEELLKTDVKLLNGNHENGDLDPTSPL---- 67

  Fly   170 KLDETEEHASAKESTQKTEDLADSDEILKSKEEDEVPANTADNIEKDRKNTSTDDVFMYALDC-- 232
               |..::...||.....|::....|..|: |..|.|...:.|:    ||...||     |:|
Human    68 ---ENMDYIKDKEEVNGIEEICFDPEGSKA-EWKETPCILSVNV----KNKQDDD-----LNCEP 119

  Fly   233 ----------IS-------SAD----EFDA-------FASQDSKKAKPSKKLNTENNSSVNDLED 269
                      :|       |.|    :.||       .||.||....|:....:.::::..|...
Human   120 LSPHNITPEPVSKLPAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPTSSEPSSSDAASGDATS 184

  Fly   270 ISSDDDDIIK-ETEKPNTEVIDLDS----SSECVPCE-----------AESEVEETEANTEDTEV 318
            ..:...|:.. :....:....||.|    ||:.:|.|           |..::..:|..:.|  :
Human   185 GDAPSGDVSPGDATSGDATADDLSSGDPTSSDPIPGEPVPVEPISGDCAADDIASSEITSVD--L 247

  Fly   319 LTHGKVSTKKSLNLQNNISEKSASAAEYESVKADQHLTEGKEPMLVGDEVTEKS-------KESI 376
            .:....||..:       |:..||.....|..|...|..|:   |..||:|.:|       .:|:
Human   248 ASGAPASTDPA-------SDDLASGDLSSSELASDDLATGE---LASDELTSESTFDRTFEPKSV 302

  Fly   377 PIQSEESIQVD--EPEESKESEELEEHKEKEEPDYCKETKDSEEATEKEKSEIKIIKASKVAQIL 439
            |: .|...::|  ||..:|:.:.||::...|:.:.. ::|||.:  ||.|::..|
Human   303 PV-CEPVPEIDNIEPSSNKDDDFLEKNGADEKLEQI-QSKDSLD--EKNKADNNI---------- 353

  Fly   440 GDTKEEEDPSPTQEVED--VKETEEPENKKEIEDTEELEEPVVIE---GEETEDPQKKV---QKE 496
             |..||     |.|.:|  :.....|||:|::      ||.::.|   ||:......::   :|.
Human   354 -DANEE-----TLETDDTTICSDRPPENEKKV------EEDIITELALGEDAISSSMEIDQGEKN 406

  Fly   497 FDVRTAD--HEMNYTTIDDKLDEAV---------KDVVEIEEKKA-AEDEL------GVIPKGDK 543
            .|..:||  ..:|...|:|...|.:         .:::.|.||.| :||||      .::|..:.
Human   407 EDETSADLVETINENVIEDNKSENILENTDSMETDEIIPILEKLAPSEDELTCFSKTSLLPIDET 471

  Fly   544 EPTTNGACEISTDGNLKDLESNES-------TVVEEETKETESDDEVIFFEPLDKTENVGTTANP 601
            .|......| |:.|:....||:||       .:.:||....|.|:.    |.:.:.|........
Human   472 NPDLEEKME-SSFGSPSKQESSESLPKEAFLVLSDEEDISGEKDES----EVISQNETCSPAEVE 531

  Fly   602 TNENSVKPQAKDDEVVLVSEDEDETPQNGISEKEVQTIQKETALKGLPNESTTESVEAKNLQIDN 666
            :||...||:  ::|.|:..:||..:.:|..|.::                      .:|:..:||
Human   532 SNEKDNKPE--EEEQVIHEDDERPSEKNEFSRRK----------------------RSKSEDMDN 572

  Fly   667 SDNACDQF--EKLKTHDMVKQTTTEDGNSNSSNLLRPAEYAEESVPKRLRLSTDEKNEFEAETNQ 729
            ..:...::  |:.:....||.|...|.|   ..|.:..::..|.....|:.:..:|...|.:|..
Human   573 VQSKRRRYMEEEYEAEFQVKITAKGDIN---QKLQKVIQWLLEEKLCALQCAVFDKTLAELKTRV 634

  Fly   730 ESLP------------------ILSRAEGGLKDVTKRSHEHLDSSPQEEIPNKKAKTEDSDSNSS 776
            |.:.                  :..|.|...:|:.|| |||..:.|..  |.|.....:|::|.|
Human   635 EKIECNKRHKTVLTELQAKIARLTKRFEAAKEDLKKR-HEHPPNPPVS--PGKTVNDVNSNNNMS 696

  Fly   777 HE--GTLQIDMGGQEDKEESPKKDTQKKLDFDLNPVPEIKQNVKPLRLEFFKTFRRSFDTMTRDD 839
            :.  ||::                          .:.|.|:||.......|:|   ..:|::..:
Human   697 YRNAGTVR--------------------------QMLESKRNVSESAPPSFQT---PVNTVSSTN 732

  Fly   840 LEELVLQKVVEAMMVKSDFAEIRMQLDKCESTLANYRRKIAEVSKQFLDLETVHKRVLKDLEAKN 904
            |       |....:|.|   :.::|               ..|:...|...:|       |.|.|
Human   733 L-------VTPPAVVSS---QPKLQ---------------TPVTSGSLTATSV-------LPAPN 765

  Fly   905 SHFTAPVRITRAVGLQVGIPFKAIKPTV----------------AAPE--STHAAGSVLAPPSG- 950
               ||.|..|..|      |....:||:                :.|:  .:|....|...|||
Human   766 ---TATVVATTQV------PSGNPQPTISLQPLPVILHVPVAVSSQPQLLQSHPGTLVTNQPSGN 821

  Fly   951 -------TPPKAS------------TSPTRATVRPRPPPPTF--GPSTSSSETGAGVSVTPNSNH 994
                   :||..|            .:||:....|..|.|:.  .|:.|::..|..::|
Human   822 VEFISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVPSPSIQRNPTASAAPLGTTLAV------ 880

  Fly   995 QQQQPAARSSQSLTTASV---------TPPVRRGCLQKVTPHRPVPT------NLQPAPMLMNQS 1044
             |..|.|.|....|..|:         :|...||.:|...|.....|      |....|.:.||:
Human   881 -QAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRGPIQMKIPISAFSTSSAAEQNSNTTPRIENQT 944

  Fly  1045 SVQRLQS-SPPIAQRTMHASKHTGTPGSTPSSVANAINKTVMRARNSEAAFLAQKQQQKQH---- 1104
            :.....| |...|..|....|.||:..|      ..|:.|:    :.|.:..:|..::..|
Human   945 NKTIDASVSKKAADSTSQCGKATGSDSS------GVIDLTM----DDEESGASQDPKKLNHTPVS 999

  Fly  1105 -QQQQQQQQQHLQQQQKQQQAQQQFLLPRPSPGPTPGSSPA--KQVPKCTTKVRAKQPPLSGATV 1166
             ....|...:.||..|.....|       ||..||.|.|..  ..:|...|.|.....|::..|.
Human  1000 TMSSSQPVSRPLQPIQPAPPLQ-------PSGVPTSGPSQTTIHLLPTAPTTVNVTHRPVTQVTT 1057

  Fly  1167 SVPISSSSSGSELGSYGQQQESSLAPAKPKEKAVIDLTDEDDAAAAAAARAAQAQNA-RLRMEML 1230
            .:|:..:.:       ..|...:..||.|.:..:     ......|.|.|....||: .:|:...
Human  1058 RLPVPRAPA-------NHQVVYTTLPAPPAQAPL-----RGTVMQAPAVRQVNPQNSVTVRVPQT 1110

  Fly  1231 KRNAQTAAATRGGRGGGNVVRASPMQLPRVNARQIVHNNGGGQQSPLGSNVTMQIRSENTPPPAS 1295
            .........|.|..|....|...|.|         ||                      |.||
Human  1111 TTYVVNNGLTLGSTGPQLTVHHRPPQ---------VH----------------------TEPP-- 1142

  Fly  1296 RLRYSHPAPLPTSP-PQPFNPSWKVP--PSRPVIRISLLDT--GIVISWTLEDSSPRFAECVMYQ 1355
              |..||||||.:| ||...|.....  |.:|.::::.:.:  |||:||::.:.....|....|.
Human  1143 --RPVHPAPLPEAPQPQRLPPEAASTSLPQKPHLKLARVQSQNGIVLSWSVLEVDRSCATVDSYH 1205

  Fly  1356 IYAYQETINEPST---DSWRHVGDVSAMLLPMAVTLNQFQENQRYYFAVRGVDSHERFGPFSVPK 1417
            :|||.|   |||.   ..|:.:|:|.|:.||||.||.||....:||||||..|.:.|||||..|:
Human  1206 LYAYHE---EPSATVPSQWKKIGEVKALPLPMACTLTQFVSGSKYYFAVRAKDIYGRFGPFCDPQ 1267

  Fly  1418 T 1418
            :
Human  1268 S 1268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wde	NP_610608.1	PTZ00121	<154..818	CDD:173412	164/773 (21%)
		DUF5585	<927..>1074	CDD:465521	44/202 (22%)
		fn3_4	1320..1418	CDD:465273	41/104 (39%)
ATF7IP	NP_851997.1	MSCRAMM_ClfA	<130..441	CDD:468110	76/348 (22%)
		PTZ00341	<327..582	CDD:173534	67/308 (22%)
		ATF7IP_BD	572..787	CDD:465271	56/290 (19%)
		PHA03247	<675..1166	CDD:223021	130/633 (21%)
		fn3_4	1168..1268	CDD:465273	41/102 (40%)