Protein Alignment wde and Atf7ip

DIOPT Version :10

• Sequence 1: NP_610608.1
• Gene: wde / 36133
• FlyBaseID: FBgn0027499
• Length: 1420
• Species: Drosophila melanogaster
• Sequence 2: XP_006506453.1
• Gene: Atf7ip / 54343
• MGIID: 1858965
• Length: 1317
• Species: Mus musculus
• Alignment Length: 1521
• Identity: 331/1521 - (21%)
• Similarity: 522/1521 - (34%)
• Gaps: 450/1521 - (29%)

  Fly    36 TPAILNESSQTSVDEVD--------LCELT--------NGVDSSDN----VKVIDKPKKISDRER 80
            ||.:.|.:.:...::::        .|:|:        :|..:|||    ..|.|.|  .||
Mouse    99 TPCMPNVAVKNKQEDLNSEALSPSITCDLSSRVTTEPGSGSPASDNPGCGTPVSDNP--ASD--- 158

  Fly    81 NPGSDLDALLDKISSIVDCSPRNSDDIDSLDRDEECDSASAKKRTAADTDENLKEQREKPEEEEE 145
            ||.||..|               ||:.||.|.     :|.....|...|.::..|  |.|..:..
Mouse   159 NPASDNPA---------------SDNPDSGDL-----AAGELATTVQATGDSACE--EPPSSDPS 201

  Fly   146 GEEVLSSLEGEE---CIDPDSELKTEEKLDETEEHASAKESTQKTEDLADSDEILKSKEEDEVPA 207
            ..:..||.....   |.:|.|.       |...|.|:       :.||...|.........|..:
Mouse   202 SSDPTSSEPSSSEPTCSEPISG-------DPVSEEAA-------SHDLVSGDSTCSEPVSGEPVS 252

  Fly   208 NTADNIEKDRKNTSTDD-VFMYALDCISSADEFDAFASQDSKKAKPSKKLNTENNSSVNDLEDIS 271
            :.|.:.|......::|: |......|..:..|                          :.|:|.:
Mouse   253 HEAASSEPATSEPASDEPVARVVAACELAPGE--------------------------SALDDCA 291

  Fly   272 SDDDDIIKETEKPNTEVIDLDSSSECVPCEAESEVEETEANTEDTEVLTHGKVSTKKSLNLQNNI 336
            ...|.  :..|.|::|    ||....| |...:..|           ||.|::|.:.:.:
Mouse   292 PSGDS--QSDEPPSSE----DSLPRSV-CSGLASGE-----------LTPGELSVEPATD----- 333

  Fly   337 SEKSASAAEYESVKADQHLTEGKEPMLVGDEVTEKSKESIPIQSEESIQVDEPEESKESEELEEH 401
            :.|.:|:|..|:         |.:|     :.||.|..:         ..|.|.:|::.|.|::.
Mouse   334 TVKPSSSAVCEA---------GPDP-----DKTEPSSNN---------SDDCPGKSEDDEHLDQI 375

  Fly   402 KEKEEPDYCKE-TKDSEEATEKEK----------SEIKIIKASKVAQ--ILGDTKEEEDPSPTQE 453
            :.|   |.|.| .|.:....|||:          |::.....:|:|:  |.....|||..|.:.|
Mouse   376 QSK---DSCDEGNKVNSNVVEKEEPLETHSAIICSDLPPENTTKIAEDPIAEPALEEEAISSSME 437

  Fly   454 VEDVKETEEPENKKEIEDTEELEEPVVIEGEETEDPQKKVQKEFDVRTADHEMNYTTIDDKLDEA 518
            |:   ::|:.|:|..       .|||   ...:|||            |:.:...|.:|:.....
Mouse   438 VD---QSEKDEHKSP-------AEPV---AAVSEDP------------AEEDKEDTVVDNTDSME 477

  Fly   519 VKDVVEIEEKKA-AEDELGVIPKGDKEPTTNGACEISTDGNLKDLESNESTVVEEETKETESDDE 582
            ..:::.|.||.| .||||....|....|.                             ||..|.|
Mouse   478 TDEIIPILEKLAPTEDELSCFSKASLLPV-----------------------------ETSQDLE 513

  Fly   583 VIFFEPLDKTENVGTTANPTNENSVKPQAKDDEVVLVSEDEDETPQNGISEKEVQTIQKETALKG 647
                   ||.|  |:..:|:.:.|.:...|  |..||..||::. ..|..|.|.....|.:..:|
Mouse   514 -------DKME--GSFGSPSKQESSENLPK--EAFLVLSDEEDL-SCGKDESEAVAQSKMSTPEG 566

  Fly   648 LPNESTTESVEAKNLQIDNSD---NACDQFEKLKTHDMVKQTTTEDGNSNSSNLLRPAEYAEESV 709
            ..:|...::.|.:.:..:...   :..|:|.:.      |::.:||               .:||
Mouse   567 EKSEKDGKAEEEERVPAEEQPPVRSTYDEFSRR------KRSKSED---------------MDSV 610

  Fly   710 PKRLRLSTDEKNEFEAETNQESLPILSRAEGGLKDVTKRSHEHLDSSPQEE------------IP 762
            ..:.|...||  |:|||     ..:...|:|   |:.::..:.:....||:            :.
Mouse   611 ESKRRRYMDE--EYEAE-----FQVKITAKG---DINQKLQKVIQWLLQEKLCALQCAVFDKTLA 665

  Fly   763 NKKAKTEDSDSNSSHEGT---LQIDMGGQEDKEESPKKDTQKKLDFDLNPVPEIKQNVKPLRLEF 824
            ..|.:.|..:.|..|:..   ||..:.....:..:.|.|.:|:.:..  |.|.|... ||..
Mouse   666 ELKTRVEKIECNKRHKAVLTELQAKIARLTKRFGAAKDDLKKRQESP--PNPPISPG-KPAN--- 724

  Fly   825 FKTFRRSFDTMTRDDLEELVLQKVVEAMMVKSDFAEIRMQLDKCESTLANYRRKIAEVSKQFLD- 888
                    ||.:.::             |...:...:|..|:.        :|.::|.......
Mouse   725 --------DTNSNNN-------------MTYRNAGTVRQLLES--------KRNVSEGPPPSFQT 760

  Fly   889 -LETVHKRVLKDLEAKNSHFTAPVRITRAVGLQVGIPFKAI--KPTVAAPESTHAAGSVLAPPSG 950
             :.||         :..||.|:...::....||......::  .|.:.|| ||....:....|||
Mouse   761 PVNTV---------SSASHATSTAVVSSQPKLQTSATSGSLPAAPLLPAP-STATVVATTQVPSG 815

  Fly   951 TP-PKASTSPTRATVRPRPPPPTFGPSTSSSETGAGVSVTPNSNHQ----QQQPAARSSQSLTTA 1010
            || |..|..|....:.. |...|..|....|..|..|:..|:.|.:    |.||..   ..||..
Mouse   816 TPQPTISLQPLPVILHV-PVAVTSQPQLLQSHPGTLVTNQPSGNVEFISVQSQPTV---SGLTKN 876

  Fly  1011 SVTPPVRRGCLQKVTPHRPVPTNLQ-----PAPMLMNQSSVQRLQSSPPIAQRTMHASKHTGTPG 1070
            .|:.|......:...|..|.|:::|     .|..|....:||.:.::..|.|.|..:....|..|
Mouse   877 PVSLPPLPNPTKPNIPSVPSPSSIQRNSSTTAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSG 941

  Fly  1071 --------------------STPSS------------VANAINKTVMRARNSEAAFLAQKQQQKQ 1103
                                |.|||            ..|..||||..:.|.:||....:..:..
Mouse   942 LYSSSSSRGPIQMKIPISTFSPPSSAEQNSSATPRIVTENQTNKTVDSSINKKAADSTSQSGKAS 1006

  Fly  1104 HQQQ-------QQQQQQHLQQQQKQ--------------QQAQQQFLLPRP--SPGPTPGSSPAK 1145
            ....       ...::....|..|:              .....|.:||.|  .|...|.|.|::
Mouse  1007 SSDSSGVIDLTMDDEESGTTQDPKKISPPSSSTVSTSQPMSRPLQPILPAPPLQPSGVPTSGPSQ 1071

  Fly  1146 Q----VPKCTTKVRAKQPPLSGATVSVPISSSSSGSELGSYGQQQESSLAPAKPKEKAVIDLTDE 1206
            .    :|...|.|.....|::..|..:|:..:.:       ..|...:..|| |..:|.:..|
Mouse  1072 ATIHVLPTAPTTVNVTHRPVTQVTTRLPVPRAPA-------NHQVVYTTLPA-PTTQAPLRGT-- 1126

  Fly  1207 DDAAAAAAARAAQAQNA-RLRMEMLKRNAQTAAATRGGRGGGNVVRASPMQLPRVNARQIVHNNG 1270
              ...|.|.|....||: .:|:............|.|..|....|...|.|         |||.
Mouse  1127 --VMQAPAVRQVNPQNSVTVRVPQTTTYVVNNGLTLGSAGPQLTVHHRPPQ---------VHNE- 1179

  Fly  1271 GGQQSPLGSNVTMQIRSENTPPPASRLRYSHPAPLPTSP-PQPFNPSWKVP--PSRPVIRISLLD 1332
                                 ||    |..||||||.:| ||...|.....  |.:|.::::.:.
Mouse  1180 ---------------------PP----RPLHPAPLPEAPQPQRLPPEAASTSLPQKPHLKLARVQ 1219

  Fly  1333 T--GIVISWTLEDSSPRFAECVMYQIYAYQETINEPST---DSWRHVGDVSAMLLPMAVTLNQFQ 1392
            :  |||:||::.:.....|....|.:|||.|   |||.   ..|:.:|:|.|:.||||.||.||.
Mouse  1220 SQNGIVLSWSVLEVDRSCATVDSYHLYAYHE---EPSATVPSQWKKIGEVKALPLPMACTLTQFV 1281

  Fly  1393 ENQRYYFAVRGVDSHERFGPFSVPKT 1418
            ...:||||||..|.:.|||||..|::
Mouse  1282 SGSKYYFAVRAKDIYGRFGPFCDPQS 1307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wde	NP_610608.1	PTZ00121	<154..818	CDD:173412	139/699 (20%)
		DUF5585	<927..>1074	CDD:465521	42/178 (24%)
		fn3_4	1320..1418	CDD:465273	41/104 (39%)
Atf7ip	XP_006506453.1	PHA03307	91..>370	CDD:223039	75/383 (20%)
		Agg_substance	315..>572	CDD:411439	81/364 (22%)
		ATF7IP_BD	609..824	CDD:465271	54/269 (20%)
		PHA03247	<877..1221	CDD:223021	79/390 (20%)
		fn3_4	1207..1307	CDD:465273	41/102 (40%)