DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wde and Atf7ip

DIOPT Version :9

Sequence 1:	NP_001286294.1	Gene:	wde / 36133	FlyBaseID:	FBgn0027499	Length:	1420	Species:	Drosophila melanogaster
Sequence 2:	XP_006506453.1	Gene:	Atf7ip / 54343	MGIID:	1858965	Length:	1317	Species:	Mus musculus

Alignment Length:	1521	Identity:	331/1521 - (21%)
Similarity:	522/1521 - (34%)	Gaps:	450/1521 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 TPAILNESSQTSVDEVD--------LCELT--------NGVDSSDN----VKVIDKPKKISDRER 80
            ||.:.|.:.:...::::        .|:|:        :|..:|||    ..|.|.|  .||
Mouse    99 TPCMPNVAVKNKQEDLNSEALSPSITCDLSSRVTTEPGSGSPASDNPGCGTPVSDNP--ASD--- 158

  Fly    81 NPGSDLDALLDKISSIVDCSPRNSDDIDSLDRDEECDSASAKKRTAADTDENLKEQREKPEEEEE 145
            ||.||..|               ||:.||.|.     :|.....|...|.::..|  |.|..:..
Mouse   159 NPASDNPA---------------SDNPDSGDL-----AAGELATTVQATGDSACE--EPPSSDPS 201

  Fly   146 GEEVLSSLEGEE---CIDPDSELKTEEKLDETEEHASAKESTQKTEDLADSDEILKSKEEDEVPA 207
            ..:..||.....   |.:|.|.       |...|.|:       :.||...|.........|..:
Mouse   202 SSDPTSSEPSSSEPTCSEPISG-------DPVSEEAA-------SHDLVSGDSTCSEPVSGEPVS 252

  Fly   208 NTADNIEKDRKNTSTDD-VFMYALDCISSADEFDAFASQDSKKAKPSKKLNTENNSSVNDLEDIS 271
            :.|.:.|......::|: |......|..:..|                          :.|:|.:
Mouse   253 HEAASSEPATSEPASDEPVARVVAACELAPGE--------------------------SALDDCA 291

  Fly   272 SDDDDIIKETEKPNTEVIDLDSSSECVPCEAESEVEETEANTEDTEVLTHGKVSTKKSLNLQNNI 336
            ...|.  :..|.|::|    ||....| |...:..|           ||.|::|.:.:.:
Mouse   292 PSGDS--QSDEPPSSE----DSLPRSV-CSGLASGE-----------LTPGELSVEPATD----- 333

  Fly   337 SEKSASAAEYESVKADQHLTEGKEPMLVGDEVTEKSKESIPIQSEESIQVDEPEESKESEELEEH 401
            :.|.:|:|..|:         |.:|     :.||.|..:         ..|.|.:|::.|.|::.
Mouse   334 TVKPSSSAVCEA---------GPDP-----DKTEPSSNN---------SDDCPGKSEDDEHLDQI 375

  Fly   402 KEKEEPDYCKE-TKDSEEATEKEK----------SEIKIIKASKVAQ--ILGDTKEEEDPSPTQE 453
            :.|   |.|.| .|.:....|||:          |::.....:|:|:  |.....|||..|.:.|
Mouse   376 QSK---DSCDEGNKVNSNVVEKEEPLETHSAIICSDLPPENTTKIAEDPIAEPALEEEAISSSME 437

  Fly   454 VEDVKETEEPENKKEIEDTEELEEPVVIEGEETEDPQKKVQKEFDVRTADHEMNYTTIDDKLDEA 518
            |:   ::|:.|:|..       .|||   ...:|||            |:.:...|.:|:.....
Mouse   438 VD---QSEKDEHKSP-------AEPV---AAVSEDP------------AEEDKEDTVVDNTDSME 477

  Fly   519 VKDVVEIEEKKA-AEDELGVIPKGDKEPTTNGACEISTDGNLKDLESNESTVVEEETKETESDDE 582
            ..:::.|.||.| .||||....|....|.                             ||..|.|
Mouse   478 TDEIIPILEKLAPTEDELSCFSKASLLPV-----------------------------ETSQDLE 513

  Fly   583 VIFFEPLDKTENVGTTANPTNENSVKPQAKDDEVVLVSEDEDETPQNGISEKEVQTIQKETALKG 647
                   ||.|  |:..:|:.:.|.:...|  |..||..||::. ..|..|.|.....|.:..:|
Mouse   514 -------DKME--GSFGSPSKQESSENLPK--EAFLVLSDEEDL-SCGKDESEAVAQSKMSTPEG 566

  Fly   648 LPNESTTESVEAKNLQIDNSD---NACDQFEKLKTHDMVKQTTTEDGNSNSSNLLRPAEYAEESV 709
            ..:|...::.|.:.:..:...   :..|:|.:.      |::.:||               .:||
Mouse   567 EKSEKDGKAEEEERVPAEEQPPVRSTYDEFSRR------KRSKSED---------------MDSV 610

  Fly   710 PKRLRLSTDEKNEFEAETNQESLPILSRAEGGLKDVTKRSHEHLDSSPQEE------------IP 762
            ..:.|...||  |:|||     ..:...|:|   |:.::..:.:....||:            :.
Mouse   611 ESKRRRYMDE--EYEAE-----FQVKITAKG---DINQKLQKVIQWLLQEKLCALQCAVFDKTLA 665

  Fly   763 NKKAKTEDSDSNSSHEGT---LQIDMGGQEDKEESPKKDTQKKLDFDLNPVPEIKQNVKPLRLEF 824
            ..|.:.|..:.|..|:..   ||..:.....:..:.|.|.:|:.:..  |.|.|... ||..
Mouse   666 ELKTRVEKIECNKRHKAVLTELQAKIARLTKRFGAAKDDLKKRQESP--PNPPISPG-KPAN--- 724

  Fly   825 FKTFRRSFDTMTRDDLEELVLQKVVEAMMVKSDFAEIRMQLDKCESTLANYRRKIAEVSKQFLD- 888
                    ||.:.::             |...:...:|..|:.        :|.::|.......
Mouse   725 --------DTNSNNN-------------MTYRNAGTVRQLLES--------KRNVSEGPPPSFQT 760

  Fly   889 -LETVHKRVLKDLEAKNSHFTAPVRITRAVGLQVGIPFKAI--KPTVAAPESTHAAGSVLAPPSG 950
             :.||         :..||.|:...::....||......::  .|.:.|| ||....:....|||
Mouse   761 PVNTV---------SSASHATSTAVVSSQPKLQTSATSGSLPAAPLLPAP-STATVVATTQVPSG 815

  Fly   951 TP-PKASTSPTRATVRPRPPPPTFGPSTSSSETGAGVSVTPNSNHQ----QQQPAARSSQSLTTA 1010
            || |..|..|....:.. |...|..|....|..|..|:..|:.|.:    |.||..   ..||..
Mouse   816 TPQPTISLQPLPVILHV-PVAVTSQPQLLQSHPGTLVTNQPSGNVEFISVQSQPTV---SGLTKN 876

  Fly  1011 SVTPPVRRGCLQKVTPHRPVPTNLQ-----PAPMLMNQSSVQRLQSSPPIAQRTMHASKHTGTPG 1070
            .|:.|......:...|..|.|:::|     .|..|....:||.:.::..|.|.|..:....|..|
Mouse   877 PVSLPPLPNPTKPNIPSVPSPSSIQRNSSTTAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSG 941

  Fly  1071 --------------------STPSS------------VANAINKTVMRARNSEAAFLAQKQQQKQ 1103
                                |.|||            ..|..||||..:.|.:||....:..:..
Mouse   942 LYSSSSSRGPIQMKIPISTFSPPSSAEQNSSATPRIVTENQTNKTVDSSINKKAADSTSQSGKAS 1006

  Fly  1104 HQQQ-------QQQQQQHLQQQQKQ--------------QQAQQQFLLPRP--SPGPTPGSSPAK 1145
            ....       ...::....|..|:              .....|.:||.|  .|...|.|.|::
Mouse  1007 SSDSSGVIDLTMDDEESGTTQDPKKISPPSSSTVSTSQPMSRPLQPILPAPPLQPSGVPTSGPSQ 1071

  Fly  1146 Q----VPKCTTKVRAKQPPLSGATVSVPISSSSSGSELGSYGQQQESSLAPAKPKEKAVIDLTDE 1206
            .    :|...|.|.....|::..|..:|:..:.:       ..|...:..|| |..:|.:..|
Mouse  1072 ATIHVLPTAPTTVNVTHRPVTQVTTRLPVPRAPA-------NHQVVYTTLPA-PTTQAPLRGT-- 1126

  Fly  1207 DDAAAAAAARAAQAQNA-RLRMEMLKRNAQTAAATRGGRGGGNVVRASPMQLPRVNARQIVHNNG 1270
              ...|.|.|....||: .:|:............|.|..|....|...|.|         |||.
Mouse  1127 --VMQAPAVRQVNPQNSVTVRVPQTTTYVVNNGLTLGSAGPQLTVHHRPPQ---------VHNE- 1179

  Fly  1271 GGQQSPLGSNVTMQIRSENTPPPASRLRYSHPAPLPTSP-PQPFNPSWKVP--PSRPVIRISLLD 1332
                                 ||    |..||||||.:| ||...|.....  |.:|.::::.:.
Mouse  1180 ---------------------PP----RPLHPAPLPEAPQPQRLPPEAASTSLPQKPHLKLARVQ 1219

  Fly  1333 T--GIVISWTLEDSSPRFAECVMYQIYAYQETINEPST---DSWRHVGDVSAMLLPMAVTLNQFQ 1392
            :  |||:||::.:.....|....|.:|||.|   |||.   ..|:.:|:|.|:.||||.||.||.
Mouse  1220 SQNGIVLSWSVLEVDRSCATVDSYHLYAYHE---EPSATVPSQWKKIGEVKALPLPMACTLTQFV 1281

  Fly  1393 ENQRYYFAVRGVDSHERFGPFSVPKT 1418
            ...:||||||..|.:.|||||..|::
Mouse  1282 SGSKYYFAVRAKDIYGRFGPFCDPQS 1307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wde	NP_001286294.1	fn3_4	1320..1418	CDD:293399	41/104 (39%)
Atf7ip	XP_006506453.1	PHA03307	91..>370	CDD:223039	75/383 (20%)
		MDN1	<298..634	CDD:227596	104/476 (22%)
		ATF7IP_BD	609..820	CDD:374802	52/265 (20%)
		PHA03247	<877..1221	CDD:223021	79/390 (20%)
		fn3_4	1207..1307	CDD:374807	41/102 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838223
Domainoid	1	1.000	79	1.000	Domainoid score	I8670
eggNOG	1	0.900	-	-		E1_28K6G
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I4802
Isobase	1	0.950	-	0	Normalized mean entropy	S8538
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007416
OrthoInspector	1	1.000	-	-		otm42776
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23210
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8307
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.920