DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33144 and CUL7

DIOPT Version :9

Sequence 1:	NP_001188904.1	Gene:	CG33144 / 36131	FlyBaseID:	FBgn0053144	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	XP_016867022.1	Gene:	CUL7 / 9820	HGNCID:	21024	Length:	1795	Species:	Homo sapiens

Alignment Length:	286	Identity:	69/286 - (24%)
Similarity:	99/286 - (34%)	Gaps:	102/286 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   527 SIVQYTGLRKCETVLALTRQSQSHGHVHGLS----QSR-SQG---HSLAVHGSGIFSSGGVEQIR 583
            ||...||:.|...||.|.        :|.||    |.| |.|   .:|:.|.:|....|  |:.:
Human   201 SIEPLTGVFKDPRVLDLL--------MHMLSSPDYQIRWSAGRMIQALSSHDAGEGQCG--EEGK 255

  Fly   584 P---LNRLRNSVSSINGVGTC--SRCSSLLSLAASGSRYSLSNGFAPRPTSALNHLEAGWEDDQR 643
            .   |.|||:|..::.|....  :|...||||:                              |:
Human   256 AGEGLGRLRDSQDTVAGASDLIRTRTQILLSLS------------------------------QQ 290

  Fly   644 RAQEPHINVN---AQIRLSGGATANS--------TSPSPPSNVTTAT----LHSSS----ANNLN 689
            .|.|.|::.:   |.:.|...||.:.        ..|..|..|..:.    ||.:|    .|:..
Human   291 EAIEKHLDFDSRCALLALFAQATLSEHPMSFEGIQLPQVPGRVLFSLVKRYLHVTSLLDQLNDSA 355

  Fly   690 QEP-QQSTSTPATTPTETPGSGELGPFGTNHAYPL--TVSSLLSMASANQAAQACCVRDGIALKR 751
            .|| .|:||.|...      |||.|......:..:  .:|.|:.....:||:.          :.
Human   356 AEPGAQNTSAPEEL------SGERGQLELEFSMAMGTLISELVQAMRWDQASD----------RP 404

  Fly   752 REMLAS---------ADVTPSVGTPA 768
            |....|         |||:|  |.||
Human   405 RSSARSPGSIFQPQLADVSP--GLPA 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
CG33144	NP_001188904.1	IBR	850..956	CDD:214763
CG33144	NP_001188904.1	IBR	<976..1014	CDD:279784
CUL7	XP_016867022.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010