DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG33144 and SHARPIN

DIOPT Version :10

Sequence 1:NP_788324.1 Gene:CG33144 / 36131 FlyBaseID:FBgn0053144 Length:1102 Species:Drosophila melanogaster
Sequence 2:NP_112236.3 Gene:SHARPIN / 81858 HGNCID:25321 Length:387 Species:Homo sapiens


Alignment Length:510 Identity:98/510 - (19%)
Similarity:147/510 - (28%) Gaps:220/510 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   371 AGGAGAGVGFGGGGGGGSGNGGVLAA--------NGGGDLESS---LGLSGGGQLPRRRRIENFL 424
            ||||.|       .....|:..||.|        ..|.|.|:.   |.||...:.|.|.|:|   
Human     5 AGGAAA-------AASDLGSAAVLLAVHAAVRPLGAGPDAEAQLRRLQLSADPERPGRFRLE--- 59

  Fly   425 KSLVGLKASSGRGGGGGGNVGGGGAVPDRERPASPEIRITRTPSEQDVVLRDPSGRQLANGHGRG 489
              |:|               .|.||| :.|.|........|.|::.:  |:.|.|       |.|
Human    60 --LLG---------------AGPGAV-NLEWPLESVSYTIRGPTQHE--LQPPPG-------GPG 97

  Fly   490 SLSISGSSSSLNVVQQKIWHIMRREGSASSLHQEKSQSIVQYTGLRKCETVLALTRQS------- 547
            :||:    ..||..:.:.|.::.|..:....:..||.| ....|...|...|....::       
Human    98 TLSL----HFLNPQEAQRWAVLVRGATVEGQNGSKSNS-PPALGPEACPVSLPSPPEASTLKGPP 157

  Fly   548 ------QSHGHVHGLSQSRSQGHSLAVHGSGIFSSGGVEQIRPLNRLRNSVSSINGVGTCSRCSS 606
                  :|.|:   |::......|||...:|....|..:....|.:.|.::|    |.....|  
Human   158 PEADLPRSPGN---LTEREELAGSLARAIAGGDEKGAAQVAAVLAQHRVALS----VQLQEAC-- 213

  Fly   607 LLSLAASGSRYSLSNGFAPRPTSALNHLEAGWEDDQRRAQEPHINVNAQIRLSGGATANSTSPSP 671
                            |.|.|                        :..|:.|...|:|.|.:.|.
Human   214 ----------------FPPGP------------------------IRLQVTLEDAASAASAASSA 238

  Fly   672 ------PSNVTTATLHSSSANNLNQE--------------PQQSTST--------PA-----TTP 703
                  ..:.|.|.|.....:.|...              |::|.::        ||     :.|
Human   239 HVALQVHPHCTVAALQEQVFSELGFPPAVQRWVIGRCLCVPERSLASYGVRQDGDPAFLYLLSAP 303

  Fly   704 TETPGS-----------GELGPFGTNHAYPLTVSSLLSMASANQAAQACCVRDGIALKRREMLAS 757
            .|.|.:           ||||     ..:|                                   
Human   304 REAPATGPSPQHPQKMDGELG-----RLFP----------------------------------- 328

  Fly   758 ADVTPSVGTPATPTTA-------FKP-FTCKLC-LIDVEDVGEAMALQQCGCQFC 803
                ||:|.|..|..|       .:| ::|..| .|:..|        :.||:.|
Human   329 ----PSLGLPPGPQPAASSLPSPLQPSWSCPSCTFINAPD--------RPGCEMC 371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG33144NP_788324.1 mRING-HC-C4C4_RBR_RNF144 777..829 CDD:438294 7/28 (25%)
BRcat_RBR_RNF144 860..961 CDD:439010
Rcat_RBR_RNF144 976..1045 CDD:439013
SHARPINNP_112236.3 Self-association. /evidence=ECO:0000250|UniProtKB:Q9EQL9 1..180 50/219 (23%)
Sharpin_PH 29..127 CDD:465263 31/131 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 122..169 8/50 (16%)
Interaction with SHANK1. /evidence=ECO:0000250|UniProtKB:Q9EQL9 175..310 30/180 (17%)
Ubl_HOIL1 218..302 CDD:340497 15/107 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 305..349 13/87 (15%)
ZnF_RBZ 351..373 CDD:197784 7/29 (24%)
RanBP2-type Zn finger 352..371 CDD:275376 6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

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