DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33144 and Cul9

DIOPT Version :9

Sequence 1:	NP_001188904.1	Gene:	CG33144 / 36131	FlyBaseID:	FBgn0053144	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	XP_011245024.1	Gene:	Cul9 / 78309	MGIID:	1925559	Length:	2580	Species:	Mus musculus

Alignment Length:	670	Identity:	141/670 - (21%)
Similarity:	224/670 - (33%)	Gaps:	210/670 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   487 GRGSLSISGSSSSLNVVQQKIWHIMRREGSASSLHQEKSQSIVQYTGLRKC--------ETVLAL 543
            ||..|.....:..::.||  :|.:         |:..:|:.:...|.||..        :.:|.|
Mouse  1803 GRAELQFGDQTLHVSTVQ--MWLL---------LNFNQSEEVSVETLLRNSDLSPELLHQALLPL 1856

  Fly   544 T----------RQSQSHGHVHGLSQSRSQGHS--LAVHGSGIFSSGGVEQIRPLNRLRNSVSSI- 595
            |          .|....|.|..|.:.|||.|.  |.:.....:.|...::.|.|.:.||.:|.:
Mouse  1857 TSDNGPLTLEETQDYPQGGVLRLREPRSQTHEEVLWLIPPQTYLSVEKDEGRTLEQKRNLLSCLL 1921

  Fly   596 ---------NGVGTCSRCSSLLSLAASGSRYS------LSN----GFAPRPTSALN---HLEAGW 638
                     .|:    ....|:.|.....:..      |.|    |.|...|..|:   || .|.
Mouse  1922 VRILKAHREKGL----HIDQLVCLVLEAWQKGPDPPGRLGNAAAVGVACSSTDVLSCILHL-LGQ 1981

  Fly   639 EDDQRRAQEPHINV------------NAQIRLSGGATANSTSPSPPSNVTTATLHSSSANNLNQE 691
            ...:||...|.:.:            .|.:...|.....::.|||.:.|..|:|...:...::
Mouse  1982 GYVERRDDRPQVLMYATPEPMGPCRGQADVPFCGNKNTETSRPSPEAVVALASLQLPAGRTMS-- 2044

  Fly   692 PQQSTSTPATTPTETPGSGELGPFGTNHAYPLTVSSLLS---------MASANQAAQACCVRDGI 747
            ||:.......|..:...:..|.|....|        ||:         :.|.:...:...:..|:
Mouse  2045 PQEVEGLMEQTVRQVQETLNLEPDVAQH--------LLAHSHWGTEQLLQSYSDDPEPLLLAAGL 2101

  Fly   748 ALKRREMLASADVTPSVGTPATPTTAFKPFTCKLCL--IDVEDVGEAMALQQCGCQFCIECMRAY 810
            .:.:      |.|.|:           :|..|.:|:  :...|...::....|.|:   .|...|
Mouse  2102 RVPQ------AQVVPT-----------RPDQCPVCVTPLGPHDDSPSLCCLHCCCK---SCWNEY 2146

  Fly   811 VEFEISEG-AYEISCPDATCPAQ--GA-----ISLPEIANLTTTNLLKKHHRYRLNREIELDKTR 867
            :...|.:. ....:||.|.||||  ||     :|.||:        :.|:.:..|...:|.....
Mouse  2147 LTTRIEQNFVLNCTCPIADCPAQPTGAFIRNIVSSPEV--------ISKYEKALLRGYVESCSNL 2203

  Fly   868 TWCPR-AGCETICTVGAAAQPGQSSVICQMDESPSTSQSYSPQQEVAGNGSTGAAAGNGAPVLSV 931
            |||.. .||:.|              :|               ::..|:|:|
Mouse  2204 TWCTNPQGCDRI--------------LC---------------RQGLGSGTT------------- 2226

  Fly   932 SVHCPSCKDEFCGLCK--KAYHPNISCDEFGRRLIADG--QDDIGIPFDNE-----LIKCCPMCA 987
               |..|....|..|.  :|::| .||.... :.:.||  .|.:.:...::     :.|.||.|.
Mouse  2227 ---CSKCGWASCFSCSFPEAHYP-ASCGHMS-QWVDDGGYYDGMSVEAQSKHLAKLISKRCPSCQ 2286

  Fly   988 VPIEKDEGCAQMMCKRCKHVFCWYCLASLDDDFLLRHYD------KGPCKNKLG----------- 1035
            .||||:|||..|.|.||.|.|||.||.|....    |.|      ...|...||
Mouse  2287 APIEKNEGCLHMTCARCNHGFCWRCLKSWKPS----HKDYYNCSAMEDCMKVLGEVERGLLRSPA 2347

  Fly  1036 ----HSRASVVWHRAQVIGI 1051
                ||..|:..|:...:.:
Mouse  2348 YQNVHSHLSMCLHQEFAVNL 2367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33144	NP_001188904.1	IBR	850..956	CDD:214763	19/108 (18%)
CG33144	NP_001188904.1	IBR	<976..1014	CDD:279784	20/42 (48%)
Cul9	XP_011245024.1	Cul7	382..456	CDD:371573
		APC10-like	1184..1314	CDD:382862
		COG5647	<1736..1989	CDD:227934	43/201 (21%)
		Cullin	<1740..1856	CDD:366357	12/63 (19%)
		RING_Ubox	2115..2166	CDD:388418	11/53 (21%)
		RING-HC finger (C3HC4-type)	2116..2166	CDD:319361	11/52 (21%)
		IBR	2187..2249	CDD:214763	19/107 (18%)
		IBR	<2280..2315	CDD:366672	21/34 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820