DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33144 and Rnf19b

DIOPT Version :9

Sequence 1:	NP_001188904.1	Gene:	CG33144 / 36131	FlyBaseID:	FBgn0053144	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_001355692.1	Gene:	Rnf19b / 75234	MGIID:	1922484	Length:	732	Species:	Mus musculus

Alignment Length:	485	Identity:	112/485 - (23%)
Similarity:	164/485 - (33%)	Gaps:	134/485 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   624 APRPTSALNHLEAGWEDDQRRAQEPHINVNAQIRLSGGATANSTSPSPPSNVTTATLHSSSANNL 688
            :||.||    |.|...|.:.|              |||.....|..|    |.:|   |:.....
Mouse     9 SPRSTS----LHAAAPDPKCR--------------SGGRRRRLTFHS----VFSA---SARGRRA 48

  Fly   689 NQEPQQSTSTPATTPTETPGSGELGPFGTNHAYPLTVSSLLSMASANQAAQACCVRDGIALKRRE 753
            ..:||.....||..|...|.:    |.......| .|.:|.|..:|...|:|      :|....|
Mouse    49 RTKPQAEPPPPAAPPPPPPPA----PAPVEAQAP-PVEALPSEPAAEAEAEA------VAAGPEE 102

  Fly   754 MLASADVTPSVGTPATPTTAFKPFTCKLCLIDVEDVGEAMALQQCGCQFCIECMRAYVEFEISEG 818
                        ..|......:...|.|||:.:.. ..|..|..|..:.|.:|:|.|:..||||.
Mouse   103 ------------DEAAEGGGAEEVECPLCLVRLPP-ERAPRLLSCPHRSCRDCLRHYLRLEISES 154

  Fly   819 AYEISCPDATCPAQGAISLPEIAN-------LTTTNLLKKHHRYRLNREIELDKTRTWCPRAGC- 875
            ...||||:.:          |..|       |....|:.|:..:.|.|.:..|....|||...|
Mouse   155 RVPISCPECS----------ERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCG 209

  Fly   876 ETICTVGAAAQPGQSSVICQMDESPSTSQSYSPQQEVAGNGSTGAAAGNGAPVLSVSVHCPSCKD 940
            ..:...|.|:.|   .:.|:.:                                       .|:.
Mouse   210 YAVIAYGCASCP---KLTCERE---------------------------------------GCQT 232

  Fly   941 EFCGLCKKAYHPNISCD----EFGRRLIADGQDDIGIPFDNEL-----IKCCPMCAVPIEK--DE 994
            |||..||:.:|||.:||    :..:.|....:...|:.:..|.     ||.||.|:..|.|  |.
Mouse   233 EFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG 297

  Fly   995 GCAQMMCKRCKHVFCWYCLASLDDDFLLRHYDKGPCK---NKLGHSRASVVWHRAQVIGIFAGFG 1056
            .|..|.|..|...|||.|:..:.|   |.:.....|.   .|....:..::|....:||...|..
Mouse   298 SCNHMTCAVCGCEFCWLCMKEISD---LHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGIS 359

  Fly  1057 ILLLVASPLLLLAAPCIICCKCRGCTGSKI 1086
            ::..:|.|.:::..|..:        |.||
Mouse   360 LIAGIAIPAMVIGIPVYV--------GRKI 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33144	NP_001188904.1	IBR	850..956	CDD:214763	21/106 (20%)
CG33144	NP_001188904.1	IBR	<976..1014	CDD:279784	17/44 (39%)
Rnf19b	NP_001355692.1	Required for ubiquitin ligase activity and for protection against staurosporin-induced cell death. /evidence=ECO:0000250\|UniProtKB:Q6ZMZ0	1..315		97/406 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..109		33/147 (22%)
		TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	112..334		68/277 (25%)
		RING-HC_RBR_RNF19B	116..169	CDD:319690	20/63 (32%)
		RING-HC finger (C3HC4-type)	116..163	CDD:319690	19/47 (40%)
		IBR	184..248	CDD:214763	21/105 (20%)
		IBR	<280..318	CDD:307574	16/37 (43%)
		AzlC	<344..433	CDD:351157	10/46 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..644
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..732
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810