DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33144 and Ankib1

DIOPT Version :9

Sequence 1:	NP_001188904.1	Gene:	CG33144 / 36131	FlyBaseID:	FBgn0053144	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_001276456.1	Gene:	Ankib1 / 70797	MGIID:	1918047	Length:	1091	Species:	Mus musculus

Alignment Length:	318	Identity:	74/318 - (23%)
Similarity:	117/318 - (36%)	Gaps:	93/318 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   741 CCVRDGIALKRREMLASADVTP---------SVGTPATPTTAFKPFT----------------CK 780
            ||.|.|:.:.          ||         ::.:|.||.|.....|                |.
Mouse   281 CCQRSGVQMP----------TPPPSGYNAWDTLPSPRTPRTTRSSVTSPDEISLSPGDLDTSLCD 335

  Fly   781 LCLIDVEDVGEAMALQQCGCQFCIECMRAYVEFEISEG-AYEISCPDATCPAQGAISLPEIANLT 844
            :|:..: .|.|......||..||..|..|::..:|.|| |:.|.||...|  ...:.:..|.::.
Mouse   336 ICMCSI-SVFEDPVDMPCGHDFCRGCWEAFLNLKIQEGEAHNIFCPAYEC--FQLVPVDVIESVV 397

  Fly   845 TTNLLKKHHRYRLNREIELDKTRTWCPRAGCETICTVGAAAQPGQSSVICQMDESPSTSQSYSPQ 909
            :..:.|::.::.:...:|.:....|||.||||            ::..:.:...:||.|.:.|
Mouse   398 SKEMDKRYLQFDIKAFVENNPAIKWCPTAGCE------------RAVRLTKQGSNPSGSDTLS-- 448

  Fly   910 QEVAGNGSTGAAAGNGAPVL-SVSVHCPSCKDEFCGLCKKAYHPNISCDEFGRRL---------- 963
                            .|:| :.:|.|.. ...||..|....|....|..:...|
Mouse   449 ----------------FPLLRAPAVDCGK-GHLFCWECLGEAHEPCDCQTWKNWLQKITEMKPEE 496

  Fly   964 ---IADGQDDIGIPFDNEL-----IKCCPMCAVPIEKDEGCAQMMCKRCKHVFCWYCL 1013
               :::..:|..    |.|     .|.|..|..||:|:|||..|.|.:||:.|||.||
Mouse   497 LVGVSEAYEDAA----NCLWLLTNSKPCANCKSPIQKNEGCNHMQCAKCKYDFCWICL 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33144	NP_001188904.1	IBR	850..956	CDD:214763	21/106 (20%)
CG33144	NP_001188904.1	IBR	<976..1014	CDD:279784	20/43 (47%)
Ankib1	NP_001276456.1	ANKYR	<28..199	CDD:223738
		ANK 1	45..75
		ANK repeat	47..77	CDD:293786
		ANK repeat	79..143	CDD:293786
		ANK repeat	145..176	CDD:293786
		ANK 2	145..174
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..322		10/49 (20%)
		TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	330..570		63/259 (24%)
		RING-HC_RBR_ANKIB1	333..389	CDD:319688	18/58 (31%)
		RING-HC finger (C3HC4-type)	334..384	CDD:319688	17/50 (34%)
		IBR	403..476	CDD:366672	21/103 (20%)
		IBR	502..553	CDD:366672	21/53 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..814
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	890..913
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	927..965
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1020..1091
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810