DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33144 and Cul9

DIOPT Version :9

Sequence 1:	NP_001188904.1	Gene:	CG33144 / 36131	FlyBaseID:	FBgn0053144	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	XP_038939436.1	Gene:	Cul9 / 316228	RGDID:	1562008	Length:	2541	Species:	Rattus norvegicus

Alignment Length:	711	Identity:	154/711 - (21%)
Similarity:	229/711 - (32%)	Gaps:	239/711 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   415 PRRRRIENFLKSLVGLKA----SSGRGGGG-------GGNVGGGGAVPDRERPASPEIRITRTPS 468
            ||:.....|..:|.|..:    |...|.|.       ||..|...|              ||...
  Rat  1708 PRKHLPTEFCDALDGFSSFYSHSEELGTGSWRLRCIPGGRRGKAEA--------------TRQEC 1758

  Fly   469 EQDVVL-RDPSGRQLANGHGRGSLSISGSSSSLNVVQQKIW--------------HIMRREG-SA 517
            :...|| ..|..|......||..|.....:..::.||  :|              .::|..| |.
  Rat  1759 QHYPVLDMGPHRRLQWTWLGRAELQFGDQTLHVSTVQ--MWLLLNFNQTEEVSVEILLRNSGLSP 1821

  Fly   518 SSLHQ--------------EKSQSIVQYTGLRKCETVLALTRQSQSHGHV-------HGLSQSRS 561
            ..|||              |::|...|...||..|.      :||:|..|       ..||..:.
  Rat  1822 ELLHQALLPLTSDSGPLTLEEAQDFPQGGVLRLREP------RSQTHEEVLWLIPPQTYLSVEKD 1880

  Fly   562 QGHS---------------LAVHG-SGIFSSGGVEQI------------RPLNRLRNSVSSINGV 598
            :|.:               |..|| .|:.    ::|:            .|..||..|.:    |
  Rat  1881 EGRTLEQKRNLLSCLLVRILKAHGEKGLH----IDQLVCLVLEAWQKGPNPPGRLGRSAA----V 1937

  Fly   599 GTCSRCSSLLSLAASGSRYSLSNGFAPRPTSALNHLEAGWEDDQRR-----AQEP--HINVNAQI 656
            |.....:.:||...    :.|..|:..|            .||:.:     ..||  |....|.:
  Rat  1938 GVACSSTDVLSCIL----HLLGQGYVER------------RDDRPQVLMYATPEPMGHCRGQADV 1986

  Fly   657 RLSGGATANSTSPSPPSNVTTATLHSSSANNLNQEPQQSTSTPATTPTETPGSGELGPFGTNH-- 719
            ...|..:..::.|||.:.|..|:|...:...::  ||:.......|..:...:..|.|....|
  Rat  1987 PFCGNQSTETSKPSPEAVVALASLQLPAGRTMS--PQEVEGLMEQTVRQVQETLNLEPDVAQHLL 2049

  Fly   720 AYPLTVSSLLSMASANQAAQACCVRDGIALKRREMLASADVTP-----SVGTPATPTTAFKPFTC 779
            ||        |.....|..|:               .|.|..|     .:..|.......:|..|
  Rat  2050 AY--------SHWGTEQLLQS---------------YSEDPEPLLLAAGLRVPQPQEVPARPDQC 2091

  Fly   780 KLCL--IDVEDVGEAMALQQCGCQFCIECMRAYVEFEISEG-AYEISCPDATCPAQ--GA----- 834
            .:|:  :...|...::....|.|:   .|...|:...|.:. ....:||.|.||||  ||
  Rat  2092 PVCISPLGPNDDSPSLCCLHCCCK---SCWNEYLTTRIEQNFVLNCTCPIADCPAQPTGAFIRNI 2153

  Fly   835 ISLPEIANLTTTNLLKKHHRYRLNREIELDKTRTWCPR-AGCETICTVGAAAQPGQSSVICQMDE 898
            :|.||:        :.|:.:..|...:|.....|||.. .||:.|              :|
  Rat  2154 VSSPEV--------ISKYEKALLRGYVESCSNLTWCTNPQGCDRI--------------LC---- 2192

  Fly   899 SPSTSQSYSPQQEVAGNGSTGAAAGNGAPVLSVSVHCPSCKDEFCGLCK--KAYHPNISCDEFGR 961
                       ::..|:|:|                |..|....|..|.  :|::| .||....
  Rat  2193 -----------RQGLGSGTT----------------CSKCGWASCFNCSFPEAHYP-ASCGHMS- 2228

  Fly   962 RLIADG--QDDIGIPFDNE-----LIKCCPMCAVPIEKDEGCAQMMCKRCKHVFCWYCLAS 1015
            :.:.||  .|.:.:...::     :.|.||.|..||||:|||..|.|.||.|.|||.||.|
  Rat  2229 QWVDDGGYYDGMSVEAQSKHLAKLISKRCPSCQAPIEKNEGCLHMTCARCNHGFCWRCLRS 2289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33144	NP_001188904.1	IBR	850..956	CDD:214763	19/108 (18%)
CG33144	NP_001188904.1	IBR	<976..1014	CDD:279784	20/42 (48%)
Cul9	XP_038939436.1	Cul7	366..440	CDD:402903
		APC10-like	1159..1289	CDD:382862
		Cullin	<1585..1832	CDD:395716	30/139 (22%)
		Cullin_Nedd8	1884..1964	CDD:416146	16/103 (16%)
		RING_Ubox	2090..2141	CDD:418438	11/53 (21%)
		RING-HC finger (C3HC4-type)	2091..2141	CDD:319361	11/52 (21%)
		IBR	2162..2224	CDD:214763	19/107 (18%)
		IBR	<2255..2290	CDD:396187	22/35 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820