DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33144 and RNF144B

DIOPT Version :9

Sequence 1:	NP_001188904.1	Gene:	CG33144 / 36131	FlyBaseID:	FBgn0053144	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_877434.2	Gene:	RNF144B / 255488	HGNCID:	21578	Length:	303	Species:	Homo sapiens

Alignment Length:	348	Identity:	150/348 - (43%)
Similarity:	189/348 - (54%)	Gaps:	71/348 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   751 RREMLASADVTPSVG--TPATPTTAFKP-FTCKLCLIDVEDVGEAMALQQCGCQFCIECMRAYVE 812
            |...||.....|:.|  .||       | .||||||.: :.:.:...||:|.|.||..|::.|::
Human     6 RLHYLAMTAENPTPGDLAPA-------PLITCKLCLCE-QSLDKMTTLQECQCIFCTACLKQYMQ 62

  Fly   813 FEISEG-AYEISCPDATCPAQGAISLPEIANLTTTNLLKKHHRYRLNREIELDKTRTWCPRAGCE 876
            ..|.|| ...|:|||..|...|.:...|||.|...:..:.:.|.:..||:.||..|||||.|.|:
Human    63 LAIREGCGSPITCPDMVCLNHGTLQEAEIACLVPVDQFQLYQRLKFEREVHLDPYRTWCPVADCQ 127

  Fly   877 TICTVGAAAQPGQSSVICQMDESPSTSQSYSPQQEVAGNGSTGAAAGNGAPVLSVSVHCPSCKDE 941
            |:|.| |::.|||                                     |||   |.||||..:
Human   128 TVCPV-ASSDPGQ-------------------------------------PVL---VECPSCHLK 151

  Fly   942 FCGLCKKAYHPNISCDEFGRRLIADGQDDIGIPFDNEL---------IKCCPMCAVPIEKDEGCA 997
            ||..||.|:|..:||        .|.| .|.:|.::..         ||.||:|.|.||::||||
Human   152 FCSCCKDAWHAEVSC--------RDSQ-PIVLPTEHRALFGTDAEAPIKQCPVCRVYIERNEGCA 207

  Fly   998 QMMCKRCKHVFCWYCLASLDDDFLLRHYDKGPCKNKLGHSRASVVWHRAQVIGIFAGFGILLLVA 1062
            |||||.|||.||||||.:||:|..|||||||||:||||||||||:|:|.||:||..|.||:.||.
Human   208 QMMCKNCKHTFCWYCLQNLDNDIFLRHYDKGPCRNKLGHSRASVMWNRTQVVGILVGLGIIALVT 272

  Fly  1063 SPLLLLAAPCIICCKCRGCTGSK 1085
            |||||||:||||||.|:.|.|.|
Human   273 SPLLLLASPCIICCVCKSCRGKK 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33144	NP_001188904.1	IBR	850..956	CDD:214763	33/105 (31%)
CG33144	NP_001188904.1	IBR	<976..1014	CDD:279784	25/46 (54%)
RNF144B	NP_877434.2	TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	26..244		106/268 (40%)
		mRING-HC-C4C4_RBR_RNF144B	28..84	CDD:319692	22/56 (39%)
		IBR	101..166	CDD:214763	33/105 (31%)
		IBR	<190..225	CDD:396187	26/34 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9345
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002315
OrthoInspector	1	1.000	-	-		otm41301
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11685
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X336
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.870