DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33144 and CUL9

DIOPT Version :9

Sequence 1:	NP_001188904.1	Gene:	CG33144 / 36131	FlyBaseID:	FBgn0053144	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	XP_011512724.1	Gene:	CUL9 / 23113	HGNCID:	15982	Length:	2566	Species:	Homo sapiens

Alignment Length:	628	Identity:	129/628 - (20%)
Similarity:	206/628 - (32%)	Gaps:	216/628 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   487 GRGSLSISGSSSSLNVVQQKIWHIMR----REGSASSLHQEKS-------QSIVQYTGLRKCETV 540
            ||..|........::.||  :|.:::    .|.|..:|.::..       |::|..|......|:
Human  1807 GRAELQFGKQILHVSTVQ--MWLLLKFNQTEEVSVETLLKDSDLSPELLLQALVPLTSGNGPLTL 1869

  Fly   541 LALTRQSQSHGHVHGLSQSRSQGHSLAVHGSGIFSSGGV--------------EQIRPLNRLRNS 591
                .:.|...|          |..|.:|..|...||..              ::.|.|.:.||.
Human  1870 ----HEGQDFPH----------GGVLRLHEPGPQRSGEALWLIPPQAYLNVEKDEGRTLEQKRNL 1920

  Fly   592 VSSINGVGTCSRCSSLLSLAASGSRYSLSNGF---------------APRPTSALNHLEAG---- 637
            :|          |..:..|.|.|.:     |.               .|.|...|.|..||
Human  1921 LS----------CLLVRILKAHGEK-----GLHIDQLVCLVLEAWQKGPNPPGTLGHTVAGGVAC 1970

  Fly   638 WEDD--------------QRRAQEPHINVNAQIRLSG-----------GATANSTSPSPPSNVTT 677
            ...|              :||...|.|.:.|.....|           |:.:.::.|||.:..|.
Human  1971 TSTDVLSCILHLLGQGYVKRRDDRPQILMYAAPEPMGPCRGQADVPFCGSQSETSKPSPEAVATL 2035

  Fly   678 ATLHSSSANNLNQEPQQSTSTPATTPTETPGSGELGPFGTNHAYPLTVSSLLS---------MAS 733
            |:|...:...::  ||:.......|..:...:..|.|....|        ||:         :.|
Human  2036 ASLQLPAGRTMS--PQEVEGLMKQTVRQVQETLNLEPDVAQH--------LLAHSHWGAEQLLQS 2090

  Fly   734 ANQAAQACCVRDGIALKRREMLASADVTPSVGTPATPTTAFKPFTCKLCLIDV---EDVGEAMAL 795
            .::..:...:..|:.:.:.:              |.|.   :|..|.:|:..:   :|:.....:
Human  2091 YSEDPEPLLLAAGLCVHQAQ--------------AVPV---RPDHCPVCVSPLGCDDDLPSLCCM 2138

  Fly   796 QQCGCQFCIECMRAYVEFEISEG-AYEISCPDATCPAQ--GA-----ISLPEIANLTTTNLLKKH 852
            ..|    |..|...|:...|.:. ....:||.|.||||  ||     :|.||:        :.|:
Human  2139 HYC----CKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFIRAIVSSPEV--------ISKY 2191

  Fly   853 HRYRLNREIELDKTRTWCPR-AGCETICTVGAAAQPGQSSVICQMDESPSTSQSYSPQQEVAGNG 916
            .:..|...:|.....|||.. .||:.|              :|               ::..|.|
Human  2192 EKALLRGYVESCSNLTWCTNPQGCDRI--------------LC---------------RQGLGCG 2227

  Fly   917 STGAAAGNGAPVLSVSVHCPSCKDEFCGLCK--KAYHPNISCDEFGRRLIADG--QDDIGIPFDN 977
            :|                |..|....|..|.  :|::| .||.... :.:.||  .|.:.:...:
Human  2228 TT----------------CSKCGWASCFNCSFPEAHYP-ASCGHMS-QWVDDGGYYDGMSVEAQS 2274

  Fly   978 E-----LIKCCPMCAVPIEKDEGCAQMMCKRCKHVFCWYCLAS 1015
            :     :.|.||.|..||||:|||..|.|.:|.|.|||.||.|
Human  2275 KHLAKLISKRCPSCQAPIEKNEGCLHMTCAKCNHGFCWRCLKS 2317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33144	NP_001188904.1	IBR	850..956	CDD:214763	19/108 (18%)
CG33144	NP_001188904.1	IBR	<976..1014	CDD:279784	19/42 (45%)
CUL9	XP_011512724.1	Cul7	366..440	CDD:288381
		UBA2_C	<593..638	CDD:292812
		APC10-like	1167..1297	CDD:295192
		CULLIN	1642..1813	CDD:214545	3/5 (60%)
		Cullin_Nedd8	1913..1993	CDD:299553	18/94 (19%)
		zf-RING_2	2117..2166	CDD:290367	9/52 (17%)
		IBR	2190..2252	CDD:214763	19/107 (18%)
		IBR	<2283..2321	CDD:279784	21/35 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820