DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33144 and cul9

DIOPT Version :9

Sequence 1:	NP_001188904.1	Gene:	CG33144 / 36131	FlyBaseID:	FBgn0053144	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	NP_001120525.1	Gene:	cul9 / 100145662	XenbaseID:	XB-GENE-877136	Length:	2492	Species:	Xenopus tropicalis

Alignment Length:	731	Identity:	148/731 - (20%)
Similarity:	240/731 - (32%)	Gaps:	234/731 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   489 GSLSISGSSSSLNVVQQKIWHIMRREGSASSLHQEKSQSIVQYTGLRKC---ETVLALTRQ---- 546
            |||::..|:..:.::.|    ..:||       :...:||.|.|||.:.   ..:..||.:
Frog  1733 GSLTLQVSTLQMFILLQ----FNQRE-------EVSFESITQATGLSQVLIGHALSPLTAKGAIL 1786

  Fly   547 SQSHGHVHGLSQSRSQ---GHSLAVHGSGIFSSGGVEQIRPLNRLRNSVSSI------------- 595
            :|..|::....::||:   |..|.:.....:.:...::.|.|.|.||.:..:
Frog  1787 TQEEGYLRVNGEARSEPGAGRVLRLLPRQTYLNVEEDEGRTLERKRNVIFCLITQIMKEEKELHI 1851

  Fly   596 -----NGVGTCSRCSS-----LLSLAASGS------RYSLSNGFAPRPTSALNHLEAGWEDDQR- 643
                 ..:..|.:..|     .||...|.:      .:.:|.|:..|.....:.||...:|...
Frog  1852 DNLVFRVIEACQKMESGRSLKFLSFGCSHTDVLSCIMHLISQGYVRRSDDRPHILEYLSKDPATP 1916

  Fly   644 RAQEPHINVNAQIRLSGGATANSTSPSPPSNVTTATLHS---SSANNLNQEP---------QQST 696
            ...:.||:..:..|...|..:|...||.........|.:   .....|:||.         .|.:
Frog  1917 HKGKAHISFQSPGRKRQGHGSNQPPPSSSGGTEQGVLETVLLPMGRTLSQEDVRALMGQMVAQVS 1981

  Fly   697 STPATTP---------------------TETPGSGELGPFGTNHAYPLTVSSLLSMASAN--QAA 738
            .|.:..|                     ||.|   ||          |.:||.|.:....  ::.
Frog  1982 QTLSIDPDTAQHLLIHCKWNVDLLLQKYTEEP---EL----------LLISSGLQVRDPQHPESP 2033

  Fly   739 QACCVRDGIALKRREMLASADVTPSVGTPATPTTAFKPFTCK-LCLIDVEDVGEAMALQQCGCQF 802
            |..|                   |...:|.:|........|: ||
Frog  2034 QPAC-------------------PVCVSPLSPAEHHPTLCCQHLC-------------------- 2059

  Fly   803 CIECMRAYVEFEISEG-AYEISCPDATCPAQGAIS-LPEIANLTTTNLLKKHHRYRLNREIELDK 865
            |..|.:.|:...|.:. |...:||...|.||.... :.:|  :|:..:::|:.:..|...:|...
Frog  2060 CKSCWKEYLTTRIEQNLALNCTCPTTDCLAQPTSDFISKI--ITSKEVIEKYEKSLLRGFVENCS 2122

  Fly   866 TRTWCPR-AGCETICTVGAAAQPGQSSVICQMDESPSTSQSYSPQQEVAGNGSTGAAAGNGAPVL 929
            ..|||.. .||:              .|:|:                 .|.|| |||
Frog  2123 NLTWCTNPQGCD--------------RVLCK-----------------EGLGS-GAA-------- 2147

  Fly   930 SVSVHCPSCKDEFCGLCK--KAYHPNISCDEFGRRLIADGQDDIGIPFDNE-------LIKCCPM 985
                 |..|....|..|.  :|::| .||.... :.:.||....|:..:.:       :.|.||.
Frog  2148 -----CTKCSWLSCFNCSFPEAHYP-ASCSHMS-QWMDDGGFYEGMTVEAQSKHLTKLISKHCPS 2205

  Fly   986 CAVPIEKDEGCAQMMCKRCKHVFCWYCLASLDDDFLLRHYDKGPC-----------KNKLGHSRA 1039
            |..||||:|||..|.|.:|.|.|||.||    ..:...|.|...|           |....::..
Frog  2206 CQAPIEKNEGCLHMTCAKCNHGFCWRCL----KPWKPTHKDYYNCSAMVSKAARQEKRFQDYNER 2266

  Fly  1040 SVVWHRAQVIGIFAGFGILLLVASP----LLLLAAPCIICCKCRGCTG------------SKIDE 1088
            ....|||:...:.....:.:|...|    |..|...|.:..:.|...|            .::|.
Frog  2267 CTFQHRAKDFAVSLRKRLSVLREEPPLRSLTFLITACRVLEQSRKVLGYACVYSYYNQDSERLDV 2331

  Fly  1089 VDAE---LEEEVTALQ 1101
            ::::   ||..|:|||
Frog  2332 LESQTENLELHVSALQ 2347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33144	NP_001188904.1	IBR	850..956	CDD:214763	22/108 (20%)
CG33144	NP_001188904.1	IBR	<976..1014	CDD:279784	19/44 (43%)
cul9	NP_001120525.1	Cul7	362..436	CDD:288381
		APC10-CUL7	1145..1275	CDD:176486
		Cullin_Nedd8	1827..1904	CDD:214883	12/76 (16%)
		zf-RING_2	2037..2084	CDD:290367	13/85 (15%)
		IBR	2107..2170	CDD:214763	22/108 (20%)
		IBR	<2201..2236	CDD:279784	20/38 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010